Technology Process of Benzoic acid, 4-chloro-2,3-dihydroxy-
There total 8 articles about Benzoic acid, 4-chloro-2,3-dihydroxy- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
boron tribromide;
In
dichloromethane;
at 0 - 20 ℃;
for 8h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: nitric acid; sulfuric acid / 0.08 h / -40 °C
2.1: water; 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate / tert-butyl alcohol / 0.33 h / 20 °C
3.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; water / 15.5 h
4.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C
4.2: 5 h / 0 - 20 °C
5.1: boron tribromide / dichloromethane / 6 h / 0 - 20 °C / Inert atmosphere
With
hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; sulfuric acid; palladium 10% on activated carbon; water; hydrogen; nitric acid; boron tribromide; sodium nitrite;
In
methanol; dichloromethane; water; tert-butyl alcohol;
4.1: |Sandmeyer Reaction;
DOI:10.1021/acs.joc.5b00532
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: pyridine / 5 h / 20 °C
2.1: nitric acid; sulfuric acid / 0.08 h / -40 °C
3.1: water; 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate / tert-butyl alcohol / 0.33 h / 20 °C
4.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; water / 15.5 h
5.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C
5.2: 5 h / 0 - 20 °C
6.1: boron tribromide / dichloromethane / 6 h / 0 - 20 °C / Inert atmosphere
With
pyridine; hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; sulfuric acid; palladium 10% on activated carbon; water; hydrogen; nitric acid; boron tribromide; sodium nitrite;
In
methanol; dichloromethane; water; tert-butyl alcohol;
5.1: |Sandmeyer Reaction;
DOI:10.1021/acs.joc.5b00532