METHYL 3-METHOXYPHENYLACETATE

Base Information

• Chemical Name: METHYL 3-METHOXYPHENYLACETATE
• CAS No.: 18927-05-4
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• Hs Code.: 2918990090
• Mol file: 18927-05-4.mol

Synonyms:Acetic acid, (m-methoxyphenyl)-, methyl ester;Acetic acid, 3-methoxyphenoxy, methyl ester;Methyl (3-methoxyphenyl)acetate;Methyl 2-(3-methoxyphenyl)acetate;Methyl 2-(m-methoxyphenyl)acetate;Methylm-methoxyphenylacetate;Benzeneacetic acid, 3-methoxy-, methyl ester;3-Methoxyphenylacetic acid methyl ester;

Chemical Property of METHYL 3-METHOXYPHENYLACETATE

Chemical Property:

• Vapor Pressure: 0.0176mmHg at 25°C
• Refractive Index: 1.499
• Boiling Point: 254 °C at 760 mmHg
• Flash Point: 100.2 °C
• PSA: 35.53000
• Density: 1.083 g/cm³
• LogP: 1.41070
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Sparingly soluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl2-(3-Methoxyphenyl)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Safety Statements: S24/25:Avoid contact with skin and eyes.

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 3-methoxyphenylacetate is an important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.

Technology Process of METHYL 3-METHOXYPHENYLACETATE

There total 13 articles about METHYL 3-METHOXYPHENYLACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + m-methoxyphenylacetic acid (1798-09-0) → methyl (3-methoxyphenyl)acetate (18927-05-4)

Guidance literature:

With hydrogenchloride; for 1h; Heating;

DOI:10.1016/S0968-0896(03)00220-7

Reference yield: 100.0%

m-methoxyphenylacetic acid (1798-09-0) + methyl iodide (74-88-4) → methyl (3-methoxyphenyl)acetate (18927-05-4)

Guidance literature:

With potassium carbonate; In acetone; at 60 ℃;

DOI:10.1002/adsc.201901343

Reference yield: 99.0%

→ methyl (3-methoxyphenyl)acetate (18927-05-4)

Guidance literature:

upstream raw materials:

methanol

m-methoxyphenylacetic acid

1-(3-Methoxyphenyl)ethanone

2-bromo-1,1-dimethoxy-1-(3-methoxyphenyl)ethane

Downstream raw materials:

2′,2′-dimethyl-1′-(3-methoxyphenyl)ethan-2′-ol

α-methyl-α-(3-methoxyphenyl)proprionic acid

methyl 2-(3-methoxyphenyl)-2-methylpropanoate

N-methyl-(3-methoxyphenyl)acetamide

Refernces

• 1、 ?a?ewska, Dorota,Kurczab, Rafa?,Wi?cek, Ma?gorzata,Kamińska, Katarzyna,Sata?a, Grzegorz,Jastrz?bska-Wi?sek, Magdalena,Partyka, Anna,Bojarski, Andrzej J.,Weso?owska, Anna,Kie?-Kononowicz, Katarzyna,Handzlik, Jadwiga. "The computer-aided discovery of novel family of the 5-HT6 serotonin receptor ligands among derivatives of 4-benzyl-1,3,5-triazine". . p. 117 - 124. Retrieved 2017.
• 2、 -. "Preparation method of carboxylic ester compound". Paragraph 0050-0051. . Retrieved 2021/03/30.
• 3、 Mottinelli, Marco,Sinreih, Ma?a,Ri?ner, Tea L.,Leese, Mathew P.,Potter, Barry V. L.. "N-Phenyl-1,2,3,4-tetrahydroisoquinoline: An Alternative Scaffold for the Design of 17β-Hydroxysteroid Dehydrogenase 1 Inhibitors". . p. 259 - 291. Retrieved 2020/12/07.