Piperidine, 1,1'-(1,2-phenylene)bis-

Base Information

• Chemical Name: Piperidine, 1,1'-(1,2-phenylene)bis-
• CAS No.: 27969-80-8
• Molecular Formula: C16H24N2
• Molecular Weight: 244.38
• Mol file: 27969-80-8.mol

Synonyms:

Chemical Property of Piperidine, 1,1'-(1,2-phenylene)bis-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Piperidine, 1,1'-(1,2-phenylene)bis-

There total 4 articles about Piperidine, 1,1'-(1,2-phenylene)bis- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

piperidine (110-89-4) + 1,2-dichloro-benzene (95-50-1) → N-phenyl piperidine (4096-20-2) + 1,1'-o-phenylene-bis-piperidine (27969-80-8) + 1-(2-chlorophenyl)piperidine (54121-55-0)

Guidance literature:

With styrene; tert-Amyl alcohol; sodium hydride; [2,2]bipyridinyl; nickel diacetate; In tetrahydrofuran; for 5h; Heating;

DOI:10.1016/S0040-4039(00)00276-8

Reference yield:

piperidine (110-89-4) + 1-(2-chlorophenyl)piperidine (54121-55-0) → 1,1'-o-phenylene-bis-piperidine (27969-80-8)

Guidance literature:

With potassium tert-butylate; In dimethyl sulfoxide; at 100 ℃; for 12h;

DOI:10.3184/174751913X13571448166475

Reference yield:

piperidine (110-89-4) + 2-bromo-1-chlorobenzene (694-80-4) → 1,1'-o-phenylene-bis-piperidine (27969-80-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / dimethyl sulfoxide / 12 h / 100 °C

2: potassium tert-butylate / dimethyl sulfoxide / 12 h / 100 °C

With potassium tert-butylate; In dimethyl sulfoxide;

DOI:10.3184/174751913X13571448166475

upstream raw materials:

piperidine

1,2-dichloro-benzene

2-bromo-1-chlorobenzene

1-(2-chlorophenyl)piperidine

Refernces

• 1、 Desmarets, Christophe,Schneider, Rapha?l,Fort, Yves. "Nickel-mediated amination chemistry. Part 1: Efficient aminations of (het)aryl 1,3-di and 1,3,5-trichlorides". . p. 2875 - 2879. Retrieved 2007/10/03.