Pentanedioic acid, 3-oxo-, bis(phenylmethyl) ester

Base Information

• Chemical Name: Pentanedioic acid, 3-oxo-, bis(phenylmethyl) ester
• CAS No.: 28009-82-7
• Molecular Formula: C19H18O5
• Molecular Weight: 326.349
• Mol file: 28009-82-7.mol

Synonyms:DIBENZYL ACETONE DICARBOXYLATE;1,3-acetonedicarboxylic acid dibenzylester;dibenzyl 1,3-acetonedicarboxylate;Acetondicarbonsaeure-di-benzylester;

Chemical Property of Pentanedioic acid, 3-oxo-, bis(phenylmethyl) ester

Chemical Property:

• PSA: 69.67000
• LogP: 2.82250

Purity/Quality:

DIBENZYL ACETONE DICARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pentanedioic acid, 3-oxo-, bis(phenylmethyl) ester

There total 6 articles about Pentanedioic acid, 3-oxo-, bis(phenylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-oxopentanedioic acid dimethyl ester (1830-54-2) + benzyl alcohol (100-51-6,185532-71-2) → 1,3-acetonedicarboxylic acid dibenzylester (28009-82-7)

Guidance literature:

at 170 - 180 ℃; Distillation; Neat (no solvent);

DOI:10.1002/chem.200902986

Reference yield: 82.0%

malonic acid monobenzyl ester (40204-26-0) → 1,3-acetonedicarboxylic acid dibenzylester (28009-82-7)

Guidance literature:

With O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.166667h;

DOI:10.1016/j.tetlet.2003.08.014

Reference yield: 34.0%

mono-tert-butyl malonate (40052-13-9) + malonic acid monobenzyl ester (40204-26-0) → 1,3-acetonedicarboxylic acid di(tert-butyl) ester (28009-80-5) + 1,3-acetonedicarboxylic acid dibenzylester (28009-82-7) + 1,3-acetonedicarboxylic acid benzyl tert-butyl ester (93741-00-5)

Guidance literature:

With O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2003.08.014

upstream raw materials:

3-oxopentanedioic acid dimethyl ester

benzyl alcohol

mono-tert-butyl malonate

malonic acid monobenzyl ester

Refernces

• 1、 -. "DOUBLE-HEADED PROTEASE INHIBITOR". Paragraph 1155; 1156. . Retrieved 2020/09/17.
• 2、 Balachandran, Aswathy L.,Sathi, Vidya,Deepthi, Ani,Suneesh, Chettiyam V.. "A convenient method for the synthesis of 3,6-dihydroxybenzene-1,2,4,5-tetracarboxylic acid tetraalkyl esters and a study of their fluorescence properties". supporting information. p. 327 - 337. Retrieved 2016/11/18.