Thiophenium, 1-(2,5-dihydroxyphenyl)tetrahydro-, chloride

Base Information

• Chemical Name: Thiophenium, 1-(2,5-dihydroxyphenyl)tetrahydro-, chloride
• CAS No.: 28335-08-2
• Molecular Formula: C10H13O2S.Cl
• Molecular Weight: 232.731
• Mol file: 28335-08-2.mol

Synonyms:

Chemical Property of Thiophenium, 1-(2,5-dihydroxyphenyl)tetrahydro-, chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Thiophenium, 1-(2,5-dihydroxyphenyl)tetrahydro-, chloride

There total 18 articles about Thiophenium, 1-(2,5-dihydroxyphenyl)tetrahydro-, chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

thiophene (110-01-0) + p-benzoquinone (106-51-4) → 1-(2,5-dihydroxyphenyl)thiolanium chloride monohydrate (28335-08-2)

Guidance literature:

With hydrogenchloride; In acetone; at 0 ℃; for 1h;

Reference yield: 29.4%

thiophene (110-01-0) + hydroquinone (123-31-9,8027-02-9) → 1-(2,5-dihydroxyphenyl)thiolanium chloride monohydrate (28335-08-2)

Guidance literature:

With chlorine; In methanol; 1) -50 to -60 deg C, 1.5 h, 2) 20 deg C, 1 h;

Reference yield:

3-methyltetrahydrothiophene (4740-00-5) + p-benzoquinone (106-51-4) → 1-(2,5-Dihydroxy-phenyl)-3-methyl-tetrahydro-thiophenium; chloride (111082-40-7) + 1-(2,5-dihydroxyphenyl)thiolanium chloride monohydrate (28335-08-2)

Guidance literature:

With hydrogenchloride; In acetone; at -2 - 0 ℃; Product distribution; in the presence of IIa, rel. rate constant;

DOI:10.1007/BF00522727

upstream raw materials:

thiophene

3-methyltetrahydrothiophene

p-benzoquinone

2-ethyltetrahydrothiophene

Downstream raw materials:

Acetic acid 4-acetoxy-2-(4-morpholin-4-yl-butylsulfanyl)-phenyl ester; hydrochloride

Acetic acid 4-acetoxy-2-(4-piperidin-1-yl-butylsulfanyl)-phenyl ester; hydrochloride

5-hydroxy-2-phenoxidothiolanium zwitterion

2,5-dihydroxyphenyl 4-N-morpholinobutyl sulfide hydrochloride

Refernces

• 1、 Karaulova, E.N.,Bardina, T.A.,Volynskii, N.P.,Gal'pern, G.D.,Degtyareva, I.N.,et al.. "SYNTHESIS OF 2,5-DIHYDROXYPHENYLTHIONIACYCLOALKANE SALTS". . p. 726 - 730. Retrieved 2007/10/02.