6-PhenylbenziMidazo[1,2-c]quinazoline

Base Information

• Chemical Name: 6-PhenylbenziMidazo[1,2-c]quinazoline
• CAS No.: 28381-92-2
• Molecular Formula: C20H13N3
• Molecular Weight: 295.343
• Hs Code.: 2933990090
• Mol file: 28381-92-2.mol

Synonyms:6-Phenylbenzo[4,5]imidazo[1,2-c]-quinazoline;

Chemical Property of 6-PhenylbenziMidazo[1,2-c]quinazoline

Chemical Property:

• Melting Point: 231-233 °C(Solv: ethanol (64-17-5); ligroine (8032-32-4))
• PKA: 2.62±0.30(Predicted)
• PSA: 30.19000
• Density: 1.27 g/cm³
• LogP: 4.70270
• Storage Temp.: 2-8°C

Purity/Quality:

98.5% ^*data from raw suppliers

6-Phenylbenzimidazolo[1,2-c]quinazoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Phenylbenzimidazolo[1,2-c]quinazoline, is a quinazoline derivative that can be used as in the preparation of polymers.

Technology Process of 6-PhenylbenziMidazo[1,2-c]quinazoline

There total 32 articles about 6-PhenylbenziMidazo[1,2-c]quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-phenyl-1-p-toluenesulfonylbenzimidazole (15728-51-5) + 3-phenyl-5H-1,4,2-dioxazol-5-one (19226-36-9) → 6-phenylbenzimidazolo<1,2-c>quinazoline (28381-92-2)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver bis(trifluoromethylsulfonyl)imide; In 1,2-dichloro-ethane; at 120 ℃; for 13h; Solvent; Reagent/catalyst; Temperature; Sealed tube;

DOI:10.1021/acs.joc.8b02396

Reference yield: 98.0%

2-phenyl-4-phenylaminoquinazoline (40288-70-8) → 6-phenylbenzimidazolo<1,2-c>quinazoline (28381-92-2)

Guidance literature:

With [bis(acetoxy)iodo]benzene; at 40 ℃; for 0.5h;

DOI:10.1016/j.cclet.2021.02.061

Reference yield: 96.0%

3-phenyl-5H-1,4,2-dioxazol-5-one (19226-36-9) + 2-phenyl-1H-benzoimidazole (716-79-0) → 6-phenylbenzimidazolo<1,2-c>quinazoline (28381-92-2)

Guidance literature:

With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; acetic acid; In 1,2-dichloro-ethane; at 120 ℃; for 24h; Schlenk technique; Sealed tube;

DOI:10.1002/adsc.201701331

upstream raw materials:

2-(aminophenyl)benzimidazole

benzoyl chloride

2-(2-nitrophenyl)-1H-benzimidazole

benzylamine

Refernces

• 1、 -. "Application of Aza-type iso-cryptolepine derivatives in prevention and treatment of agricultural plant diseases". Paragraph 0034-0039. . Retrieved 2020/11/25.
• 2、 Xu, Linhua,Li, Tingfang,Wang, Lianhui,Cui, Xiuling. "Rh(III)-Catalyzed One-Pot Synthesis of Benzimidazoquinazolines via C-H Amidation-Cyclization of N-LG-2-phenylbenzoimidazoles". supporting information. p. 560 - 567. Retrieved 2018/12/11.