difluoromaleic anhydride

Base Information

• Chemical Name: difluoromaleic anhydride
• CAS No.: 669-78-3
• Molecular Formula: C4F2 O3
• Molecular Weight: 134.039
• Hs Code.: 2917190090
• Mol file: 669-78-3.mol

Synonyms:Maleicanhydride, difluoro- (6CI,8CI); Difluoromaleic anhydride

Chemical Property of difluoromaleic anhydride

Chemical Property:

• Vapor Pressure: 10.1mmHg at 25°C
• Melting Point: 20 °C
• Boiling Point: 129.7°C at 760 mmHg
• Flash Point: 32.2°C
• PSA: 43.37000
• Density: 1.66g/cm³
• LogP: 0.22040

Purity/Quality:

99%, ^*data from raw suppliers

3,4-DIFLUORO-2,5-FURANDIONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of difluoromaleic anhydride

There total 3 articles about difluoromaleic anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

2,2,3-trifluorosuccinic acid (664-66-4,28812-58-0) → difluoromaleic anhydride (669-78-3)

Guidance literature:

2,2,3-trifluorosuccinic acid; With sodium hydroxide; In water; for 15h; Heating;

With phosphorus pentoxide; at 100 ℃; for 0.5h;

DOI:10.1021/ja2117848

Reference yield: 50.0%

perfluoro-2,5-dihydrofuran (24849-02-3) → difluoromaleic anhydride (669-78-3)

Guidance literature:

With sulfur trioxide; Trimethyl borate; for 12h; Heating;

DOI:10.1016/S0022-1139(00)80218-3

Reference yield:

perfluoro-2,5-dihydrofuran (24849-02-3) + Trimethyl borate (121-43-7,63156-11-6) → difluoromaleic anhydride (669-78-3)

Guidance literature:

upstream raw materials:

2,2,3-trifluorosuccinic acid

perfluoro-2,5-dihydrofuran

Trimethyl borate

Downstream raw materials:

benzyl hydrogen difluoromaleate

(E)-2,3-Difluoro-3-phenylcarbamoyl-acrylic acid

2,3-difluoro-N-phenyl-maleamic acid

N-(4-chloro-phenyl)-2,3-difluoro-maleamic acid

Refernces

• 1、 Abdo, Basil T.. "Molecular structure of 3,4-difluorofuran-2,5-dione (difluoromaleic anhydride) as determined by electron diffraction and microwave spectroscopy in the gas phase and by theoretical computations". . p. 1758 - 1767. Retrieved 2007/10/03.
• 2、 -. "Process for the preparation of difluoromaleic anhydride". . . Retrieved 2008/06/13.