Benzoyl azide, 3-(chloromethyl)-

Base Information

• Chemical Name: Benzoyl azide, 3-(chloromethyl)-
• CAS No.: 289038-87-5
• Molecular Formula: C8H6ClN3O
• Molecular Weight: 195.608
• Mol file: 289038-87-5.mol

Synonyms:

Chemical Property of Benzoyl azide, 3-(chloromethyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoyl azide, 3-(chloromethyl)-

There total 1 articles about Benzoyl azide, 3-(chloromethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chloromethylbenzoic acid (31719-77-4) → DPPA (289038-87-5)

Guidance literature:

With diphenyl phosphoryl azide; triethylamine; In 1,4-dioxane; at 20 ℃; for 0.5h;

DOI:10.1016/j.bmcl.2012.02.029

Reference yield:

DPPA (289038-87-5) → DPPA (117098-59-6)

Guidance literature:

In 1,4-dioxane; at 100 ℃; for 2h;

DOI:10.1016/j.bmcl.2012.02.029

Reference yield:

DPPA (289038-87-5) → 1-(3-((4-methoxybenzylamino)methyl)phenyl)-3-(prop-2-yn-1-yl)urea (1373331-92-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1,4-dioxane / 2 h / 100 °C

2: 1,4-dioxane / 1 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 60 °C

With potassium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide; 1: Curtius rearrangement;

DOI:10.1016/j.bmcl.2012.02.029

upstream raw materials:

3-chloromethylbenzoic acid

Downstream raw materials:

1-(3-((4-methoxybenzylamino)methyl)phenyl)-3-(prop-2-yn-1-yl)urea

1-(3-(chloromethyl)phenyl)-3-(prop-2-yn-1-yl)urea

C₁₉H₁₈N₂O₄

1-(3-((benzylamino)methyl)phenyl)-3-(prop-2-yn-1-yl)urea

Refernces

• 1、 Sanphanya, Kingkan,Wattanapitayakul, Suvara K.,Phowichit, Suwadee,Fokin, Valery V.,Vajragupta, Opa. "Novel VEGFR-2 kinase inhibitors identified by the back-to-front approach". supporting information. p. 2962 - 2967. Retrieved 2013/06/27.