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| Name |
Pyridostigmine |
EINECS | N/A |
| CAS No. | 155-97-5 | Density | g/cm3 |
| PSA | 33.42000 | LogP | 0.57150 |
| Solubility | N/A | Melting Point |
N/A |
| Formula | C9H13 N2 O2 | Boiling Point | °Cat760mmHg |
| Molecular Weight | 181.24 | Flash Point | °C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by ingestion, intramuscular, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx. See also CARBAMATES and ESTERS. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
Pyridinium,3-hydroxy-1-methyl-, dimethylcarbamate (6CI); Pyridinium, 3-hydroxy-1-methyl-,dimethylcarbamate (ester) (8CI); Pyridostigmine |
Pyridostigmine Chemical Properties
IUPAC Name: 1-Methylpyridin-1-ium-3-yl) N,N-dimethylcarbamate
Synonyms of Pyridostigmine (CAS NO.155-97-5): 3-(((Dimethylamino)carbonyl)oxy)-1-methylpyridinium ; Pyridostigminum ; Pyridinium, 3-(((dimethylamino)carbonyl)oxy)-1-methyl- (9CI) ; Pyridinium, 3-hydroxy-1-methyl-, dimethylcarbamate (ester)
CAS NO: 155-97-5
Molecular Formula: C9H13N2O2
Molecular Weight :181.2112
Molecular Structure: .png)
H bond acceptors: 4
H bond donors: 0
Freely Rotating Bonds: 2
Polar Surface Area: 33.42 Å2
Pyridostigmine Uses
Pyridostigmine (CAS NO.155-97-5) is used to treat muscle weakness in people with myasthenia gravis and to combat the effects of curariform drug toxicity.
Pyridostigmine Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intramuscular | 1867ug/kg (1.867mg/kg) | Journal of Medicinal Chemistry. Vol. 33, Pg. 577, 1990. | |
| mouse | LD50 | intraperitoneal | 2700ug/kg (2.7mg/kg) | Fundamental and Applied Toxicology. Vol. 1, Pg. 217, 1981. | |
| mouse | LD50 | subcutaneous | 3300ug/kg (3.3mg/kg) | Acta Pharmacologica et Toxicologica. Vol. 45, Pg. 9, 1979. | |
| rabbit | LD50 | intramuscular | 2800ug/kg (2.8mg/kg) | Drug and Chemical Toxicology. Vol. 3, Pg. 319, 1980. | |
| rabbit | LD50 | oral | 53900ug/kg (53.9mg/kg) | Drug and Chemical Toxicology. Vol. 3, Pg. 319, 1980. | |
| rat | LD50 | intramuscular | 2790ug/kg (2.79mg/kg) | Drug and Chemical Toxicology. Vol. 1, Pg. 355, 1978. |
Pyridostigmine Safety Profile
Poison by ingestion, intramuscular, and intraperitoneal routes. When Pyridostigmine (CAS NO.155-97-5) is heated to decomposition, it emits toxic fumes of NOx. See also CARBAMATES and ESTERS.
Pyridostigmine Specification
Pyridostigmine is a parasympathomimetic and a reversible cholinesterase inhibitor. Since it is a quaternary amine, it is poorly absorbed in the gut and does not cross the blood-brain barrier, except possibly in stressful conditions.
Contraindications: Pyrostigmine bromide is contraindicated in cases of mechanical intestinal or urinary obstruction and should be used with caution in patients with bronchial asthma .
Side effects: Common side effects include: Nausea ;Vomiting ;Diarrhea ;Abdominal cramps ;Increased salivation ;Tearing ;Increased bronchial secretions ;Constricted pupils.
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