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RICININ
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Name

RICININ

 EINECS 208-359-7
CAS No. 524-40-3 Density 1.23 g/cm3
PSA 55.02000 LogP 0.26558
Solubility soluble in water? methanol and ethanol; less in organic solvents Melting Point 200-201 °C.
Formula C8H8 N2 O2 Boiling Point 370.9 °C at 760 mmHg
Molecular Weight 164.164 Flash Point 178.1 °C
Transport Information N/A Appearance N/A
Safety A poison by ingestion and subcutaneous route. When heated to decomposition it emits toxic vapors of NOx. Risk Codes 25-36-20/21/22-11
Molecular Structure Molecular Structure of 524-40-3 (RICININE) Hazard Symbols A poison by ingestion.
Synonyms

Nicotinonitrile,1,2-dihydro-4-methoxy-1-methyl-2-oxo- (7CI,8CI); Ricinine (6CI);1,2-Dihydro-4-methoxy-1-methyl-2-oxonicotinonitrile; NSC 409913; NSC 642604;Recinine; Ricinin

Article Data 14

RICININ Synthetic route

21642-98-8

4-methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile

74-88-4

methyl iodide

524-40-3

ricinin

Conditions
ConditionsYield
Stage #1: 4-methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile With potassium tert-butylate; tetra-(n-butyl)ammonium iodide In tetrahydrofuran at 0℃;
Stage #2: methyl iodide In tetrahydrofuran at 20℃;		90%
With potassium carbonate In acetonitrile for 10h; Reflux;78%
95689-37-5

2,4-Dimethoxy-pyridin-3-carbonitril

524-40-3

ricinin

Conditions
ConditionsYield
With methyl iodide at 130℃; for 6h;70%
With methyl iodide at 155℃;
16803-45-5

1,2-dihydro-4-methoxy-1-methyl-2-oxopyridine-3-carboxylic acid

524-40-3

ricinin

Conditions
ConditionsYield
With ethylpolyphosphate; ammonia In chloroform 1a) 2 h, b) 80 deg C, 4 h;56%
21642-98-8

4-methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile

77-78-1

dimethyl sulfate

524-40-3

ricinin

Conditions
ConditionsYield
With sodium hydroxide at 0℃;53%
93769-12-1

2-Chloro-5-cyano-4-methoxy-N-methylpyrid-6-one

524-40-3

ricinin

Conditions
ConditionsYield
With sulfuric acid; zinc
74133-20-3

4-methoxypyridine-3-carbonitrile

524-40-3

ricinin

Conditions
ConditionsYield
With dimethyl sulfate; benzene Behandeln des Reaktionsprodukts mit K3 in H2O;
95689-37-5

2,4-Dimethoxy-pyridin-3-carbonitril

74-88-4

methyl iodide

524-40-3

ricinin

Conditions
ConditionsYield
at 120 - 130℃;
at 120 - 130℃; im Vakuum;
at 120 - 130℃; im Rohr;
67-66-3

chloroform

1-methyl-2,4-dioxo-1,2,3,4-tetrahydro-pyridine-3-carbonitrile; silver salt

74-88-4

methyl iodide

524-40-3

ricinin

74-88-4

methyl iodide

silver salt of/the/ ricininic acid

silver salt of/the/ ricininic acid

524-40-3

ricinin

Conditions
ConditionsYield
With chloroform
sodium-compound of/the/ ricininic acid

sodium-compound of/the/ ricininic acid

524-40-3

ricinin

Conditions
ConditionsYield
With methyl bromide at 100℃;
With dimethyl sulfate; xylene

RICININ Chemical Properties

Molecular Formula:C8H8N2O2
Molecular Weight:164.18
EINECS:208-359-7
Density:1.23 g/cm3
Melting Point:200-201 °C.
Boiling Point:370.9 °C at 760 mmHg
Flash Point:178.1 °C
Solubility:soluble in water, methanol and ethanol; less in organic solvents
Ricinin's Synonyms: RICININE;1,2-dihydro-4-methoxy-1-methyl-2-oxo-3-pyridinecarbonitril;1,2-dihydro-4-methoxy-1-methyl-2-oxo-nicotinonitril;1,2-dihydro-4-methoxy-1-methyl-2-oxonicotinonitrile;recinine;ricinin;NICOTINONITRILE,1,2-DIHYDRO-4-METHYL-2-OXO-;1,2-Dihydro-4-methoxy-1-methyl-2-oxo-3-pyridinecarbonitrile

RICININ Toxicity Data With Reference

1.   

orl-rat LDLo:75 mg/kg

   NCNSA6    National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. 5 (1953),23.
2.   

scu-mus LD50:25 mg/kg

   PBBHAU    Pharmacology, Biochemistry and Behavior. 63 (1999),367.

RICININ Safety Profile

A poison by ingestion and subcutaneous route. When heated to decomposition it emits toxic vapors of NOx.

RICININ Specification

Ricinin is a bitter white crystalline alkaloid (C8H8N2O2) extracted from the seeds of the castor-oil plant. Ingestion may cause vomiting and various other toxic reactions, including liver and kidney damage, convulsions, hypotension, and death
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