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Rescinnamine
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Name

Rescinnamine

 EINECS 246-471-8
CAS No. 24815-24-5 Density 1.31g/cm3
PSA 117.78000 LogP 4.50860
Solubility negligible

Stability

    Stable, but darkens slowly in light. Incompatible withstrong oxidizing agents.

Toxicology

    Harmful if swallowed. May be harmful if inhaled.

    Toxicity data

Melting Point 238 C
Formula C35H42 N2 O9 Boiling Point 756.8°C at 760 mmHg
Molecular Weight 634.726 Flash Point 411.5°C
Transport Information N/A Appearance white to cream powder
Safety Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. Human systemic effects by ingestion: olfactory changes, somnolence, and antipsychotic effects. Experimental reproductive effects. When heated to decomposition it emits toxic NOx. Risk Codes 25-20/21/22
Molecular Structure Molecular Structure of 24815-24-5 (RESCINNAMINE) Hazard Symbols Xn
Synonyms

3b,20a-Yohimban-16b-carboxylic acid, 18b-hydroxy-11,17a-dimethoxy-, methyl ester, 3,4,5-trimethoxycinnamate(ester) (8CI); Rescinnamine (6CI); Yohimban-16-carboxylic acid,11,17-dimethoxy-18-[[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]oxy]-,methyl ester, (3b,16b,17a,18b,20a)- (9CI);Benz[g]indolo[2,3-a]quinolizine, yohimban-16-carboxylic acid deriv.;3,4,5-Trimethoxycinnamoyl methyl reserpate; Anaprel; Apoterin; Apoterin S;Cartric; Cinnaloid; Methyl trimethoxycinnamoylreserpate; Moderil; NSC 15628;O-(3,4,5-Trimethoxy-trans-cinnamoyl) methyl reserpate; Rescinnamin; Rescisan;Resealoid; Reserpic acid methyl ester 3,4,5-trimethoxycinnamate; Reserpinine;Reserpinine (C35 alkaloid); Scinnamina

Article Data 6

Rescinnamine Chemical Properties

The Synonyms name of Rescinnamine (CAS NO.24815-24-5): 11,17alpha-Dimethoxy-18beta-((1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl)oxy)-3beta,20alpha-yohimban-16beta-carboxylic acid methyl ester ; 3,4,5-Trimethoxycinnamic acid, methyl reserpate ; 3,4,5-Trimethoxycinnamoyl methyl reserpate ; 3,4,5-Trimethylcinnamic acid, ester with methyl reserpate ; 3,4,5-Trimethylcinnamoyl methyl reserpate ; 3beta,20alpha-Yohimban-16beta-carboxylic acid, 18beta-Hydroxy-11,17alpha-dimethoxy-, methyl ester, 3,4,5-
trimethoxycinnamate (ester), (E)- ; 4-25-00-01323 (Beilstein Handbook Reference) ; AI3-52763 ; Anaprel ; Apolon ; Apoterin ; BRN 0075328 ; CCRIS 4711 ; Cartric ; Cinamine ; Cinatabs ; Cinnaloid ; Cinnasil ; HSDB 2176 ; Methyl 18-O-(3,4,5-trimethoxycinnamoyl)reserpate ;Methyl ; 1alpha,2beta,3alpha,4,4aalpha,5,7,8,13,13bbeta,14,14aalpha-dodecahydro-2alpha,11-dimethoxy-3beta-(3,4,5-trimethoxycinnamoyloxy)benz(g)indolo(2,3-a)quinolizine-1beta-carboxylate ; Methyl reserpate 3,4,5-trimethoxycinnamic acid ester ; Methyl trimethoxycinnamoylreserpate ; Moderil ; NSC 15628 ; Normorescina ; Paresinan ; Raupyrol ; Raurescin ;Raurescine ; Recinnamine ; Recitensina ; Rescaloid ; Rescamin ; Rescidan ; Rescin ; Rescinamina ; Rescinnaminum [INN-Latin] ; Rescinpal ; Scinnamina ; Tenamine ; Trimethoxy cinnamoyl reserpate de methyl ; Trimethoxy cinnamoyl reserpate de methyl [French] ; Trimethoxycinnamoyl methyl reserpate ; Tuareg ; Yohimban-16-carboxylic acid, 11,17-dimethoxy-18-((1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl)-oxy)-, methyl ester,(3beta,16beta,17alpha,18beta(E),20alpha
CAS: 24815-24-5
EINECS: 246-471-8 
Molecular Formula: C35H42N2O9
Formula Weight: 634.72 g/mol
Molecular Structure:

Index of Refraction: 1.621 
Density: 1.31 g/cm3 
Flash Point: 411.5 °C 
Boiling Point: 756.8 °C at 760 mmHg 
Chemical Properties: white to cream powder
General Description: Odorless white to cream colored crystalline powder.
Air & Water: Reactions Insoluble in water.
 

Rescinnamine Toxicity Data With Reference

The toxicity of Rescinnamine (CAS NO.24815-24-5):

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo intravenous 35mg/kg (35mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 600, 1973.
human TDLo oral 4ug/kg/D (0.004mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ANTIPSYCHOTIC		 "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 517, 1969.
mouse LD50 intraperitoneal 65mg/kg (65mg/kg)   French Medicament Patent Document. Vol. #5226M,
mouse LD50 intravenous 56mg/kg (56mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00965,
mouse LD50 oral 1420mg/kg (1420mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 109, 1972.
mouse LD50 subcutaneous 263mg/kg (263mg/kg)   French Medicament Patent Document. Vol. #5226M,
rat LD50 intraperitoneal 250mg/kg (250mg/kg)   Drugs in Japan Vol. 6, Pg. 898, 1982.
rat LD50 oral 1gm/kg (1000mg/kg)   Drugs in Japan Vol. 6, Pg. 898, 1982.
rat LD50 subcutaneous 540mg/kg (540mg/kg)   Drugs in Japan Vol. 6, Pg. 898, 1982.

Rescinnamine Safety Profile

The Risk Statements of Rescinnamine (CAS NO.24815-24-5):R25 :Toxic if swallowed.
Safety Statements: S22:Do not breathe dust. S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
RIDADR: 1544
HazardClass: 6.1(b)
PackingGroup: III
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. Human systemic effects by ingestion: olfactory changes, somnolence, and antipsychotic effects. Experimental reproductive effects. When heated to decomposition it emits toxic NOx.

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