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| Name |
Rifamide |
EINECS | N/A |
| CAS No. | 2750-76-7 | Density | 1.3g/cm3 |
| PSA | 210.62000 | LogP | 5.43370 |
| Solubility | N/A | Melting Point |
170°C (rough estimate) |
| Formula | C43H58 N2 O13 | Boiling Point | 927.4°Cat760mmHg |
| Molecular Weight | 810.939 | Flash Point | 514.7°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. Used as an antibacterial agent. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
Acetamide,2-[(1,2-dihydro-5,6,17,19,21-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-2,7-(epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-9-yl)oxy]-N,N-diethyl-,21-acetate (7CI,8CI);2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan, rifamycin deriv.; M14; M 14 (antibiotic); N,N-Diethylrifamycin B amide; NCI 143-418; NSC 133099;NSC 143418; Ribomycin B amide, N,N-diethyl-; Rifamide; Rifampicin M 14;Rifamycin B diethylamide; Rifamycin B, N,N-diethylamide; Rifamycin M14;Rifomide; Rifomycin B diethylamide; Rifomycin M14 |
Rifamide Chemical Properties
Product Name: Rifamide
Synonyms of Rifamide (CAS NO.2750-76-7) : (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-27-[2-(Diethylamino)-2-oxoethoxy]-2,15,17,29-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo [23.3.1.1~4,7~.0~5,28~]triaconta-1(28),2,4,9,19,21,25(29),26-octaen-13-yl acetate ; 2-[(1,2-Dihydro-5,6,17,19,21-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-2,7-(epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-9-yl)oxy]-N,N-diethylacetamide 21-Acetate ; 4-O-[2-(Diethylamino)-2-oxoethyl]rifamycin ; Acetamide, 2-[[(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-21-(acetyloxy)-1,2-dihydro-5,6,17,19-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-2,7-(epoxy[1,11,13]pentadecatrienoimino)naphtho[2,1-b]furan-9-yl]oxy]-N,N-diethyl- ; N,N-Diethylrifomycin B Amide
CAS NO: 2750-76-7
Molecular Formula:C43H58N2O13
Molecular Weight :810.9262
Molecular Structure :.png)
EINECS: 220-390-8
Index of Refraction: 1.608
Surface Tension: 62.1 dyne/cm
Density: 1.3 g/cm3
Flash Point: 544.6 °C
Enthalpy of Vaporization: 149.12 kJ/mol
Boiling Point: 976.8 °C at 760 mmHg
Vapour Pressure: 0 mmHg at 25°C
Rifamide Uses
Rifamide (CAS NO.2750-76-7) is used as an antibacterial agent.
Rifamide Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | intravenous | 425mg/kg (425mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ATAXIA | Toxicology and Applied Pharmacology. Vol. 8, Pg. 126, 1966. |
| mouse | LD50 | intraperitoneal | 320mg/kg (320mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ATAXIA | Toxicology and Applied Pharmacology. Vol. 8, Pg. 126, 1966. |
| mouse | LD50 | intravenous | 315mg/kg (315mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Toxicology and Applied Pharmacology. Vol. 8, Pg. 126, 1966. |
| mouse | LD50 | oral | 2450mg/kg (2450mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ATAXIA | Toxicology and Applied Pharmacology. Vol. 8, Pg. 126, 1966. |
| mouse | LD50 | subcutaneous | 640mg/kg (640mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA BEHAVIORAL: MUSCLE WEAKNESS | Toxicology and Applied Pharmacology. Vol. 8, Pg. 126, 1966. |
| rabbit | LD50 | intravenous | 550mg/kg (550mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA BEHAVIORAL: MUSCLE WEAKNESS | Toxicology and Applied Pharmacology. Vol. 8, Pg. 126, 1966. |
| rabbit | LD50 | subcutaneous | 2500mg/kg (2500mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA BEHAVIORAL: MUSCLE WEAKNESS | Toxicology and Applied Pharmacology. Vol. 8, Pg. 126, 1966. |
| rat | LD50 | intraperitoneal | 535mg/kg (535mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ATAXIA | Toxicology and Applied Pharmacology. Vol. 8, Pg. 126, 1966. |
| rat | LD50 | intravenous | 380mg/kg (380mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA BEHAVIORAL: MUSCLE WEAKNESS | Toxicology and Applied Pharmacology. Vol. 8, Pg. 126, 1966 |
| rat | LD50 | oral | > 4gm/kg (4000mg/kg) | Toxicology and Applied Pharmacology. Vol. 8, Pg. 126, 1966. | |
| rat | LD50 | subcutaneous | 2500mg/kg (2500mg/kg) | Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. |
Rifamide Safety Profile
Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. When Rifamide (CAS NO.2750-76-7) is heated to decomposition, it emits toxic fumes of NOx.
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