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Sulfameter

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Name

Sulfameter

EINECS 211-480-8
CAS No. 651-06-9 Density 1.465 g/cm3
PSA 115.58000 LogP 2.60320
Solubility Almost do not dissolve in water and ether or ethanol-soluble acid, alkali - soluble Melting Point 214-216°C
Formula C11H12N4O3S Boiling Point 539.4 °C at 760 mmHg
Molecular Weight 280.307 Flash Point 280 °C
Transport Information N/A Appearance Crystalline Solid
Safety 26-36 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 651-06-9 (Sulfameter) Hazard Symbols IrritantXi
Synonyms

Sulfanilamide,N1-(5-methoxy-2-pyrimidinyl)- (6CI,8CI);2-(4-Aminobenzenesulfonamido)-5-methoxypyrimidine;2-Sulfa-5-methoxypyrimidine;2-Sulfanilamido-5-methoxypyrimidine;4-Amino-N-(5-methoxy-2-pyrimidinyl)benzenesulfonamide;5-Methoxy-2-sulfanilamidopyrimidine;5-Methoxysulfadiazine;AHR 857;BAY 5400;Bayrena;Berlicid;Durenat;I 2586;Kinecid;Kirocid;Kiron;Longasulf;Methoxypyrimal;N-(5-Methoxypyrimidin-2-yl)-4-aminobenzenesulfonamide;N1-(5-Methoxy-2-pyrimidinyl)sulfanilamide;NSC 683528;SH 613;Sulfameter;Sulfamethoxine;Sulfamethoxydiazine;Sulfamethoxydin;Sulfamethoxypyrimidine;Sulfametin;Sulfametorine;Sulfametoxydiazine;Sulla;Sulphameter;Sulphamethoxydiazine;Ultrax;

 

Sulfameter Specification

The Sulfameter ,its cas register number is 651-06-9.It also can be called as Sulfametoxydiazine and the IUPAC name about this chemical is 4-Amino-N-(5-methoxypyrimidin-2-yl)benzenesulfonamide .It belongs to the following product categories, such as Intermediates & Fine Chemicals, Pharmaceuticals, Sulfur & Selenium Compounds and so on. Also, it can be stored between 2°C and 8°C. It slightly soluble in water.

The Sulfameter is crystalline solid and is a long-acting sulfonamide antibacterial. It can be used as a leprostatic agent and in the treatment of urinary tract infections.Also, it has long acting sulfonamide used in leprosy, urinary, and respiratory tract infections. It is a dangerous chemical, because it irritating to eyes, respiratory system and skin. In the using process, you need to wear suitable protective clothing and in case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Except these safety informations, there are also exist other data like WGK Germany is 2 and RTECS  about this chemical is WP0525000.

Following are the chemical properties about Sulfameter :(1)#H bond acceptors: 7 ; (2)#H bond donors: 3 ; (3)#Freely Rotating Bonds: 3 ; (4)Polar Surface Area: 84.01Å2 ; (5)Index of Refraction: 1.646 ; (6)Molar Refractivity: 69.51 cm3 ; (7)Molar Volume: 191.2 cm3 ; (8)Polarizability: 27.55x10-24cm3 ; (9)Surface Tension: 75 dyne/cm; (10)Enthalpy of Vaporization: 81.68 kJ/mol ; (11)Vapour Pressure: 1.05E-11 mmHg at 25°C

This chemical can be described computed from structure:
(1)Canonical SMILES: COC1=CN=C(N=C1)NS(=O)(=O)C2=CC=C(C=C2)N
(2)InChI: InChI=1S/C11H12N4O3S/c1-18-9-6-13-11(14-7-9)15-19(16,17)10-4-2-8(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15)
(3)InChIKey: GPTONYMQFTZPKC-UHFFFAOYSA-N

The most important thing about Sulfameter is the toxicity, following is the form:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 oral 1gm/kg (1000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 695, 1961.
dog LD50 oral 1gm/kg (1000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 695, 1961.
guinea pig LD50 oral 2500mg/kg (2500mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 695, 1961.
mouse LD50 intraperitoneal 3100mg/kg (3100mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 695, 1961.
mouse LD50 intravenous 1gm/kg (1000mg/kg)   "Experimental Chemotherapy, Volume II," Schnitzer, R.J., and F. Hawking, eds. Academic Press New York, 1964Vol. 2, Pg. 249, 1964.
mouse LD50 oral 16gm/kg (16000mg/kg)   Biochemical Pharmacology. Vol. 16, Pg. 1367, 1967.
mouse LD50 subcutaneous 2500mg/kg (2500mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 695, 1961.
rabbit LD50 intravenous 100mg/kg (100mg/kg)   "Experimental Chemotherapy, Volume II," Schnitzer, R.J., and F. Hawking, eds. Academic Press New York, 1964Vol. 2, Pg. 249, 1964.
rat LD50 intraperitoneal 2300mg/kg (2300mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 695, 1961.
rat LD50 intravenous 1gm/kg (1000mg/kg)   "Experimental Chemotherapy, Volume II," Schnitzer, R.J., and F. Hawking, eds. Academic Press New York, 1964Vol. 2, Pg. 249, 1964.
rat LD50 oral 6gm/kg (6000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 695, 1961.

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