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Cas Database |
| Name |
Tetrahydro-4-pyranol |
EINECS | 218-210-8 |
| CAS No. | 2081-44-9 | Density | 1.08 g/cm3 |
| PSA | 29.46000 | LogP | 0.15770 |
| Solubility | N/A | Melting Point |
N/A |
| Formula | C5H10O2 | Boiling Point | 183 °C at 760 mmHg |
| Molecular Weight | 102.133 | Flash Point | 87.8 °C |
| Transport Information | N/A | Appearance | Yellow powder |
| Safety | 26-39-36/37/39-23 | Risk Codes | 41-36/37/38-20/22 |
| Molecular Structure |
|
Hazard Symbols |
 Xn,  Xi
|
| Synonyms |
2H-Pyran-4-ol,tetrahydro-;Pyran-4-ol,tetrahydro- (6CI,7CI);4-Hydroxytetrahydro-2H-pyran;4-Hydroxytetrahydropyran;Tetrahydro-2H-pyran-4-ol;Tetrahydro-2H-pyranol-4-ol; |
Article Data | 16 |
Tetrahydro-4-pyranol Synthetic route
- 29943-42-8
Tetrahydro-4H-pyran-4-one
- 2081-44-9
Tetrahydro-pyran-4-ol
| Conditions | Yield |
|---|---|
| Stage #1: Tetrahydro-4H-pyran-4-one With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 0.5h; Stage #2: With sodium hydroxide In tetrahydrofuran; water | 99% |
| With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 5℃; for 3h; | 96% |
| With C15H18BF3; hydrogen; tert-butylimino-tri(pyrrolidino)phosphorane In tetrahydrofuran at 75℃; under 75007.5 Torr; for 40h; Glovebox; | 93% |
| Conditions | Yield |
|---|---|
| Stage #1: 1,3,5-Trioxan; homoalylic alcohol With formic acid at 80℃; for 4h; Stage #2: With isopropyl alcohol; methanesulfonic acid at 64℃; Product distribution / selectivity; | 84% |
| Stage #1: 1,3,5-Trioxan; homoalylic alcohol With formic acid at 80℃; for 4 - 12.5h; Stage #2: With ethanol; methanesulfonic acid at 20 - 64℃; Product distribution / selectivity; | 81% |
| Stage #1: 1,3,5-Trioxan; homoalylic alcohol With formic acid at 80℃; for 4h; Stage #2: With methanol; methanesulfonic acid at 64℃; Product distribution / selectivity; | 79% |
- 50-00-0
formaldehyd
- 187737-37-7
propene
A
- 1120-97-4
4-methyl-1,3-dioxane
B
- 2081-44-9
Tetrahydro-pyran-4-ol
C
- 18826-95-4, 107-88-0
1.3-butanediol
| Conditions | Yield |
|---|---|
| With cerium(IV) oxide Reagent/catalyst; | A 26% B 11% C 60% |
| Conditions | Yield |
|---|---|
| With indium(III) bromide; 1,1,3,3-Tetramethyldisiloxane In toluene at 60℃; for 1h; Inert atmosphere; | 17% |
| Conditions | Yield |
|---|---|
| With nickel Hydrogenation; | |
| Multi-step reaction with 2 steps 1: Raney nickel; ethanol / Hydrogenation.bei Raumtemperatur unter Normaldruck 2: Raney nickel / Hydrogenation View Scheme |
| Conditions | Yield |
|---|---|
| With sulfuric acid; water |
- 50-00-0
formaldehyd
- 627-27-0
homoalylic alcohol
A
- 2081-44-9
Tetrahydro-pyran-4-ol
B
- 5684-93-5
2-[1,3]dioxan-4-yl-ethanol
| Conditions | Yield |
|---|---|
| With sulfuric acid |
- 78870-52-7
(1SR,6RS)-3,7-dioxa-bicyclo[4.1.0]heptane
A
- 19752-84-2
Oxan-3-ol
B
- 2081-44-9
Tetrahydro-pyran-4-ol
| Conditions | Yield |
|---|---|
| With lithium aluminium tetrahydride In pentane for 4h; Ambient temperature; |
- 2081-44-9
Tetrahydro-pyran-4-ol
| Conditions | Yield |
|---|---|
| With water; platinum Hydrogenation; |
| Conditions | Yield |
|---|---|
| at 110℃; under 36775.4 Torr; Hydrogenation; |
Tetrahydro-4-pyranol Chemical Properties
Empirical Formula: C5H10O2
Molecular Weight: 102.1317
EINECS: 218-210-8
Index of Refraction: 1.467
Molar Refractivity: 26.25 cm3
Molar Volume: 94.4 cm3
Surface Tension: 36 dyne/cm
Density: 1.08 g/cm3
Flash Point: 87.8 °C
Enthalpy of Vaporization: 48.8 kJ/mol
Boiling Point: 183 °C at 760 mmHg
Vapour Pressure: 0.227 mmHg at 25 °C
Structure of Tetrahydro-4-pyranol (CAS NO.2081-44-9):
.gif){kind=small}
IUPAC Name: Oxan-4-ol
Canonical SMILES: C1COCCC1O
InChI: InChI=1S/C5H10O2/c6-5-1-3-7-4-2-5/h5-6H,1-4H2
InChIKey: LMYJGUNNJIDROI-UHFFFAOYSA-N
Product Category of Tetrahydro-4-pyranol (CAS NO.2081-44-9): Alcohols and Derivatives;Heterocycles;Pyrans, Piperidines & Piperazines
Tetrahydro-4-pyranol Safety Profile
Hazard Codes of Tetrahydro-4-pyranol (CAS NO.2081-44-9): 
Xi,
Xn
Risk Statements: 41-36/37/38-20/22
R20/22:Harmful by inhalation and if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
R41:Risk of serious damage to the eyes.
Safety Statements: 26-39-36/37/39-23
S23:Do not breathe vapour.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S39:Wear eye / face protection.
WGK Germany: 3
Hazard Note: Irritant
Tetrahydro-4-pyranol Specification
Tetrahydro-4-pyranol , its cas register number is 2081-44-9. It also can be called Tetrahydropyran-4-ol ; 4-Hydroxytetrahydropyran ; and 2H-Pyran-4-ol, tetrahydro .
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