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Name	Triazolam	EINECS	249-307-3
CAS No.	28911-01-5	Density	1.46 g/cm³
PSA	43.07000	LogP	3.66910
Solubility	soluble in alcohol and poorly soluble in water.	Melting Point	209-212°C
Formula	C17H12 Cl2 N4	Boiling Point	535.6 °C at 760 mmHg
Molecular Weight	343.215	Flash Point	277.7 °C
Transport Information	N/A	Appearance	white crystalline powder
Safety	22-24/25-26-36-45-36/37-16-7	Risk Codes	11-23/24/25-36/38-39/23/24/25
Molecular Structure		Hazard Symbols	TF
Synonyms	4H-s-Triazolo[4,3-a][1,4]benzodiazepine,8-chloro-6-(o-chlorophenyl)-1-methyl- (8CI);8-Chloro-1-methyl-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine; DII-18-2; Halcion; Novodorm; Songar; Triazolam; U 33030	Article Data	19

Triazolam Chemical Properties

IUPAC Name: 8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine (28911-01-5)
Synonyms : 8-Chloro-6-[2-chlorophenyl]-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
Product Categories: Organics;Intermediates & Fine Chemicals;Pharmaceuticals
Molecular Structure:
Molecular Formula : C₁₇H₁₂C_l2N₄
Molecular Weight : 343.21
CAS Registry Number : 28911-01-5
EINECS: 249-307-3
Mol File: 28911-01-5.mol
Surface Tension: 53.4 dyne/cm
Density: 1.46 g/cm³
Flash Point: 277.7 °C
Storage temp: 2-8°C
Enthalpy of Vaporization: 81.21 kJ/mol
Boiling Point: 535.6 °C at 760 mmHg
Vapour Pressure: 1.51E-11 mmHg at 25°C

Triazolam Uses

Triazolam (28911-01-5) sedative, hypnotic.,controlled Substance.

Triazolam Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
human	TDLo	oral	7ug/kg (0.007mg/kg)	BRAIN AND COVERINGS: CHANGES IN SURFACE EEG BEHAVIORAL: SLEEP BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"	Journal of Clinical Pharmacology. Vol. 14, Pg. 102, 1974.
human	TDLo	oral	29ug/kg (0.029mg/kg)	BEHAVIORAL: SLEEP BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 38, Pg. 2597, 1996.
human	TDLo	oral	114ug/kg/4D-I (0.114mg/kg)	BEHAVIORAL: TOXIC PSYCHOSIS	British Medical Journal. Vol. 304, Pg. 1178, 1992.
man	TDLo	oral	1786ng/kg (0.001786mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"	Southern Medical Journal. Vol. 80, Pg. 1425, 1987.
man	TDLo	oral	3289ng/kg (0.003289mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ALTERATION OF OPERANT CONDITIONING	Clinical Pharmacology and Therapeutics Vol. 49, Pg. 581, 1991.
man	TDLo	oral	7ug/kg (0.007mg/kg)	BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION	Journal of Toxicology, Clinical Toxicology. Vol. 33, Pg. 185, 1995.
man	TDLo	oral	100ug/kg (0.1mg/kg)	BEHAVIORAL: SLEEP BEHAVIORAL: ATAXIA CARDIAC: PULSE RATE	Journal of Clinical Psychiatry. Vol. 47, Pg. 50, 1986.
man	TDLo	oral	107ug/kg (0.107mg/kg)	BEHAVIORAL: COMA	Archives of Internal Medicine. Vol. 145, Pg. 663, 1985.
man	TDLo	oral	357ug/kg (0.357mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: IRRITABILITY BEHAVIORAL: COMA	Human & Experimental Toxicology. Vol. 11, Pg. 289, 1992.
mouse	LD50	intraperitoneal	1625mg/kg (1625mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983.
mouse	LD50	oral	1080mg/kg (1080mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"	Cesko-Slovenska Farmacie. Vol. 37, Pg. 443, 1988.
mouse	LD50	subcutaneous	> 5gm/kg (5000mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 25, Pg. 499, 1983.
rat	LD50	intraperitoneal	> 3300mg/kg (3300mg/kg)		Drugs in Japan Vol. -, Pg. 860, 1995.
rat	LD50	oral	> 7500mg/kg (7500mg/kg)		Yakkyoku. Pharmacy. Vol. 35, Pg. 1074, 1984.
rat	LD50	subcutaneous	> 5gm/kg (5000mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 25, Pg. 499, 1983.
women	TDLo	oral	100ug/kg (0.1mg/kg)	BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: CYANOSIS LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	American Journal of Emergency Medicine. Vol. 3, Pg. 210, 1985.

Triazolam Safety Profile

Hazard Codes F,T
Risk Statements 11-36/38-39/23/24/25
11: Triazolam (28911-01-5) is highly Flammable.
36/38: Irritating to eyes and skin
39/23/24/25: Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed
Safety Statements 22-24/25-26-45-36/37-16-7
7: Keep container tightly closed
16: Keep Triazolam (28911-01-5) away from sources of ignition - No smoking
22: Do not breathe dust
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
24/25: Avoid contact with skin and eyes
36/37: Wear suitable protective clothing and gloves
RIDADR 3249
WGK Germany 2
RTECS XZ5472500
HazardClass 6.1(b)
PackingGroup III