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CAS No.: | 10048-13-2 |
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Name: | STERIGMATOCYSTIN |
Molecular Structure: | |
Formula: | C18H12O6 |
Molecular Weight: | 324.29 |
Synonyms: | 7H-Furo[3',2':4,5]furo[2,3-c]xanthen-7-one,3a,12c-dihydro-8-hydroxy-6-methoxy- (7CI,8CI);7H-Furo[3',2':4,5]furo[2,3-c]xanthen-7-one,3a,12c-dihydro-8-hydroxy-6-methoxy-, (3aR-cis)-;Sterigmatocystin (6CI);NSC201423;NSC 204985;Sterigmatocystine; |
EINECS: | 233-158-6 |
Density: | 1.51 g/cm3 |
Melting Point: | 249-251℃ |
Boiling Point: | 569.7 °C at 760 mmHg |
Flash Point: | 215.9 °C |
Appearance: | yellow needles or powder |
Hazard Symbols: | T |
Risk Codes: | 25-40 |
Safety: | 36/37-45 |
Transport Information: | UN 3462 6.1/PG 3 |
PSA: | 78.13000 |
LogP: | 3.00640 |
Empirical Formula: C18H12O6
Molecular Weight: 324.2843
EINECS: 233-158-6
Storage temp: 2-8 °C
Appearance: Yellow needles or powder
Form: Powder
Color: Yellow
Index of Refraction: 1.686
Density: 1.51 g/cm3
Flash Point: 215.9 °C
Enthalpy of Vaporization: 88.65 kJ/mol
Boiling Point: 569.7 °C at 760 mmHg
Vapour Pressure: 1.39E-13 mmHg at 25 °C
Structure of Sterigmatocystin (CAS NO.10048-13-2):
Sterigmatocystin (CAS NO.10048-13-2) is mainly produced by the fungi Aspergillus nidulans and A. versicolor.
1. | dnr-bcs 10 µg/disc | MUREAV Mutation Research. 97 (1982),339. | ||
2. | dns-hmn:hla 1 µmol/L | CNREA8 Cancer Research. 38 (1978),2621. | ||
3. | msc-hmn:emb 100 µg/L | KIKNAJ Kokuritsu Idengaku Kenkyusho Nempo. Annual Report of the National Institute of Genetics.(29)(1978),38. | ||
4. | orl-rat TDLo:175 mg/kg/52W-C:CAR | FCTXAV Food and Cosmetics Toxicology. 8 (1970),289. | ||
5. | skn-rat TDLo:560 mg/kg/70W-I:CAR | TXAPA9 Toxicology and Applied Pharmacology. 26 (1973),274. | ||
6. | orl-rat LD50:120 mg/kg | FCTXAV Food and Cosmetics Toxicology. 7 (1969),135. | ||
7. | ipr-rat LD50:65 mg/kg | FCTXAV Food and Cosmetics Toxicology. 7 (1969),135. | ||
8. | orl-mus LD50:800 mg/kg | MMAPAP Mycopathologia et Mycologia Applicata. 35 (1968),373. | ||
9. | orl-mky LD50:32 mg/kg | BJEPA5 British Journal of Experimental Pathology. 51 (1970),183. |
IARC Cancer Review: Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 10 ,1976,p. 245.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 1 ,1972,p. 175.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.
Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by ingestion and intraperitoneal routes. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes of Sterigmatocystin (CAS NO.10048-13-2): T
Risk Statements: 25-40
R25 :Toxic if swallowed.
R40:Limited evidence of a carcinogenic effect.
Safety Statements: 36/37-45
S36/37:Wear suitable protective clothing and gloves.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
Sterigmatocystin ,its cas register number is 10048-13-2. It also can be called 7H-Furo(3',2':4,5)furo(2,3-c)xanthen-7-one, 3a,12c-dihydro-8-hydroxy-6-methoxy- ; 7H-furo[3',2':4,5]furo[2,3-c]xanthen-7-one, 3a,12c-dihydro-8-hydroxy-6-methoxy-, (3aR,12cS)- and (3aR,12cS)-8-Hydroxy-6-méthoxy-3a,12c-dihydro-7H-furo[3',2':4,5]furo[2,3-c]xanthén-7-one . It is a poison of the type dermatoxin, from the fungi genus Aspergillus, and is a toxic metabolite structurally closely related to the aflatoxins (compare general fact sheet number 2), and consists of a xanthone nucleus attached to a bifuran structure. The occurrence of sterigmatocystin in raw materials and foods has not been reported often. No country has legislation for Sterigmatocystin (CAS NO.10048-13-2). Natural occurrence appears to be infrequent although only a limited number of surveys have been carried out. Its relatively high levels have been formed in bread, cured ham and salami after inoculation with A. versicolor. And, methods for extraction of sterigmatocystin have been commonly based on a mixture of acetonitrile and 4% aqueous potassium chloride.