Name: TERGITOL(TM)XH(NONIONIC)
SKU: 106392-12-5

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Basic Information

Molecular Structure:
CAS No.:	106392-12-5
Name:	TERGITOL(TM)XH(NONIONIC)

Formula:	(C₃H₆O•C₂H₄O)_x
Molecular Weight:	332.48
Synonyms:	TERGITOL(TM)XH(NONIONIC);f108;f127;f77;f87;f88;methyloxiranepolymerwithoxiraneblock;oxirane,methyl-,polymerwithoxirane,block
Density:	g/cm³
Melting Point:	57-61 °C
Boiling Point:	32.9°Cat760mmHg
Flash Point:	55.2°C
Hazard Symbols:	T
Risk Codes:	61
Safety:	Low toxicity by ingestion and skin contact. When heated to decomposition it emits acrid smoke and irritating vapors.
PSA:	46.15000
LogP:	3.33230

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- China (Mainland)(20)
- United States(1)
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Chemistry

IUPAC Name: 2-Methyloxirane ; Oxirane
The MF of Poloxamer (CAS NO.106392-12-5) is C₅H₁₀O₂.

The MW of Poloxamer (CAS NO.106392-12-5) is 102.13.
Synonyms of Poloxamer (CAS NO.106392-12-5): 1,2-Propyleneglycol, ethoxylated and propoxylated
Enthalpy of Vaporization: 27.35 kJ/mol
Flash Point: 55.2 °C
Boiling Point: 32.9 °C

Uses

Poloxamer (CAS NO.106392-12-5) is used as an emulsifying agent, solubilizing agent, surfactant, and wetting agent for antibiotics. Poloxamer is also used in ointment and suppository bases and as a tablet binder or coater.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	420mg/kg (420mg/kg)		Journal of Pharmacy and Pharmacology. Vol. 34(Suppl), Pg. 533, 1982.
mouse	LD50	intravenous	129mg/kg (129mg/kg)		Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 12, Pg. 569, 1993.
mouse	LD50	intravenous	1gm/kg (1000mg/kg)		Microvascular Research. Vol. 8, Pg. 320, 1974.
mouse	LD50	intravenous	3gm/kg (3000mg/kg)		Drugs in Japan Vol. 6, Pg. 797, 1982.
mouse	LD50	oral	> 30300ug/kg (30.3mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 2291, 1981.
mouse	LD50	oral	1830mg/kg (1830mg/kg)		Journal of Pharmacy and Pharmacology. Vol. 34(Suppl), Pg. 533, 1982.
mouse	LD50	oral	15gm/kg (15000mg/kg)		Bollettino Chimico Farmaceutico. Vol. 101, Pg. 173, 1962.
mouse	LD50	subcutaneous	5500mg/kg (5500mg/kg)		Drugs in Japan Vol. 6, Pg. 797, 1982.
mouse	LD50	unreported	400mg/kg (400mg/kg)		United States Patent Document. Vol. #4043344,
mouse	LD50	unreported	530mg/kg (530mg/kg)		United States Patent Document. Vol. #4043344,
mouse	LD50	unreported	750mg/kg (750mg/kg)		United States Patent Document. Vol. #4043344,
mouse	LD50	unreported	830mg/kg (830mg/kg)		United States Patent Document. Vol. #4043344,
mouse	LD50	unreported	1250mg/kg (1250mg/kg)		United States Patent Document. Vol. #4043344,
mouse	LD50	unreported	1400mg/kg (1400mg/kg)		United States Patent Document. Vol. #4043344,
mouse	LD50	unreported	2250mg/kg (2250mg/kg)		United States Patent Document. Vol. #4043344,
mouse	LD50	unreported	2700mg/kg (2700mg/kg)		United States Patent Document. Vol. #4043344,
mouse	LD50	unreported	3gm/kg (3000mg/kg)		United States Patent Document. Vol. #4043344,
mouse	LD50	unreported	3750mg/kg (3750mg/kg)		United States Patent Document. Vol. #4043344,
mouse	LD50	unreported	4200mg/kg (4200mg/kg)		United States Patent Document. Vol. #4043344,
mouse	LD50	unreported	> 5gm/kg (5000mg/kg)		United States Patent Document. Vol. #4043344,
rabbit	LD50	skin	> 5gm/kg (5000mg/kg)		Union Carbide Data Sheet. Vol. 7/14/1965,
rat	LD50	intraperitoneal	320mg/kg (320mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LIVER: OTHER CHANGES BEHAVIORAL: ATAXIA	National Technical Information Service. Vol. OTS0540972,
rat	LD50	intraperitoneal	1140mg/kg (1140mg/kg)		Journal of Pharmacy and Pharmacology. Vol. 34(Suppl), Pg. 533, 1982.
rat	LD50	intravenous	7500mg/kg (7500mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 1204, 1981.
rat	LD50	oral	> 30300ug/kg (30.3mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 2291, 1981.
rat	LD50	oral	2300mg/kg (2300mg/kg)		Journal of Pharmacy and Pharmacology. Vol. 34(Suppl), Pg. 533, 1982.
rat	LD50	oral	5gm/kg (5000mg/kg)	VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA	Wyandotte Chemicals Corporation Reports.
rat	LD50	oral	5gm/kg (5000mg/kg)	VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA	Wyandotte Chemicals Corporation Reports.
rat	LD50	oral	5gm/kg (5000mg/kg)	VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Wyandotte Chemicals Corporation Reports.
rat	LD50	oral	9380mg/kg (9380mg/kg)		"Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972Vol. -, Pg. 297, 1972.
rat	LD50	oral	22400mg/kg (22400mg/kg)		Union Carbide Data Sheet. Vol. 7/14/1965,
rat	LD50	subcutaneous	6900mg/kg (6900mg/kg)		Drugs in Japan Vol. 6, Pg. 797, 1982.

Safety Profile

Low toxicity by ingestion and skin contact. When heated to decomposition it emits acrid smoke and irritating vapors.