CAS No.110-00-9,Furan Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	110-00-9
Name:	Furan
Article Data:	303

Formula:	C₄H₄O
Molecular Weight:	68.0752
Synonyms:	Divinyleneoxide;Furfuran;Oxacyclopentadiene;Oxole;Tetrole;
EINECS:	203-727-3
Density:	0.942 g/cm³
Melting Point:	-85.6 °C
Boiling Point:	31.36 °C at 760 mmHg
Flash Point:	-35 °C
Solubility:	insoluble in water
Appearance:	clear colorless liquid
Hazard Symbols:	T, F+
Risk Codes:	45-12-19-20/22-38-48/22-52/53-68
Safety:	53-45-61
Transport Information:	UN 2811 6.1/PG 2
PSA:	13.14000
LogP:	1.27960

Synthetic route

: 98-01-1
furfural

: 110-00-9
furan

Conditions

Conditions	Yield
With carbon dioxide; palladium/alumina at 145℃; under 45004.5 Torr; for 6.5h; Green chemistry;	99%
With carbon dioxide; 5% Pd(II)/C(eggshell) at 250℃; under 112511 Torr; Supercritical conditions;	98%
With palladium nanoparticles deposited on porous SBA-15 In cyclohexane at 150℃; for 24h; Molecular sieve;	96%

: 82660-71-7
2',6'-exo-spirodioxatricyclo<5.2.1.02,6>dec-8'-en-3'-one>

A: 110-00-9
furan

B: 5732-90-1
1-oxaspiro<4.4>non-3-en-2-one

Conditions

Conditions	Yield
In tetrahydrofuran at 130℃;	A n/a B 98%

: [3-(1-Benzylamino-pentyl)-7-oxa-bicyclo[2.2.1]hept-5-en-2-yl]-methanol

A: 110-00-9
furan

B: (Z)-4-Benzylamino-oct-2-en-1-ol

Conditions

Conditions	Yield
at 120℃; for 0.25h; Irradiation;	A n/a B 98%

: {3-[1-(4-Methoxy-benzylamino)-pentyl]-7-oxa-bicyclo[2.2.1]hept-5-en-2-yl}-methanol

A: 110-00-9
furan

B: (Z)-4-(4-Methoxy-benzylamino)-oct-2-en-1-ol

Conditions

Conditions	Yield
at 120℃; for 0.25h; Irradiation;	A n/a B 98%

: [3-(1-Dibenzylamino-pentyl)-7-oxa-bicyclo[2.2.1]hept-5-en-2-yl]-methanol

A: 110-00-9
furan

B: (Z)-4-Dibenzylamino-oct-2-en-1-ol

Conditions

Conditions	Yield
at 140℃; for 0.166667h; Irradiation;	A n/a B 98%

: {3-[4-Benzyloxy-1-(4-methoxy-benzylamino)-butyl]-7-oxa-bicyclo[2.2.1]hept-5-en-2-yl}-methanol

A: 110-00-9
furan

B: (Z)-7-Benzyloxy-4-(4-methoxy-benzylamino)-hept-2-en-1-ol

Conditions

Conditions	Yield
at 120℃; for 0.25h; Irradiation;	A n/a B 98%

: [3-(4-Benzyloxy-1-dibenzylamino-butyl)-7-oxa-bicyclo[2.2.1]hept-5-en-2-yl]-methanol

A: 110-00-9
furan

B: (Z)-7-Benzyloxy-4-dibenzylamino-hept-2-en-1-ol

Conditions

Conditions	Yield
at 140℃; for 0.166667h; Irradiation;	A n/a B 98%

: 82660-72-8
2',6'-exo-spirodioxatricyclo<5.2.1.02,6>dec-8'-en-3'-one>

A: 110-00-9
furan

B: 4435-19-2
1-oxa-spiro[4.5]dec-3-en-2-one

Conditions

Conditions	Yield
In tetrahydrofuran at 130℃; under 7 Torr;	A n/a B 97%

: 930-22-3
epoxybutene

A: 1708-29-8
2,5-dihydrofuran

B: 110-00-9
furan

C: 123-73-9
trans-Crotonaldehyde

Conditions

Conditions	Yield
tetra-n-heptylammonium iodide; tributyltin iodide In para-xylene at 109 - 117℃; for 0.75h;	A 96.1% B n/a C n/a

...Expand

: 25414-22-6
2-methoxyfuran

: 123-73-9
trans-Crotonaldehyde

dichloroacetic acid (DCA): dichloroacetic acid (DCA)

: 346440-54-8
(2S,5S)-5-benzyl-2-(tert-butyl)-3-methylimidazolidin-4-one

: 110-00-9
furan

Conditions

Conditions	Yield
In diethyl ether; chloroform	95%

...Expand

Raw Materials

74-86-2

109-99-9

1516-60-5

110-91-8

930-22-3

622-37-7

Downstream Products

106-42-3

97-99-4

689-97-4

110228-60-9

6068-62-8

Total:67 Page 1 of 2 1 2 Next>>

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Chemistry

Molecular Structure:

Molecular Formula: C₄H₄O
Molecular Weight: 68.074
IUPAC Name: Furan
Synonyms of Furan (CAS NO.110-00-9): 1,4-Epoxy-1,3-butadiene ; 5-17-01-00291 (Beilstein Handbook Reference) ; AI3-24244 ; Axole ; BRN 0103221 ; CCRIS 3159 ; Divinylene oxide ; EINECS 203-727-3 ; Furfuran ; HSDB 89 ; NCI-C56202 ; Oxacyclopentadiene ; Oxole ; RCRA waste number U124 ; Tetrole ; Furan [UN2389] [Flammable liquid] ; UN2389
CAS NO: 110-00-9
Classification Code: Mutation data ; Reproductive Effect ; Tumor data
Melting point: -85.6 °C
Index of Refraction: 1.427
Molar Refractivity: 18.55 cm³
Molar Volume: 72.2 cm³
Surface Tension: 24.8 dyne/cm
Density: 0.942 g/cm³
Enthalpy of Vaporization: 27.1 kJ/mol
Boiling Point: 31.4 °C at 760 mmHg
Vapour Pressure: 605 mmHg at 25°C
Furan is aromatic because one of the lone pairs of electrons on the oxygen atom is delocalized into the ring, creating a 4n+2 aromatic system similar to benzene. Because of the aromaticity, the molecule is flat and lacks discrete double bonds. The other lone pair of electrons of the oxygen atom extends in the plane of the flat ring system. The sp2 hybridization is to allow one of the lone pairs of oxygen to reside in a p orbital and thus allow it to interact within the pi-system.

History

In 1780 by Carl Wilhelm Scheele, the first Furan (CAS NO.110-00-9) derivative to be described was 2-furoic acid. Another important derivative, furfural, was reported by Johann Wolfgang Döbereiner in 1831 and characterised nine years later by John Stenhouse. Furan itself was first prepared by Heinrich Limpricht in 1870, although he called it tetraphenol.

Uses

Furan (CAS NO.110-00-9) is mainly used to produce large quantities of hot-box process core Binder.

Production

Furan can be obtained from FURFURAL by oxidation and decarboxylation of the resulting furan-2-carboxylic acid, the FURFURAL being derived by destructive distillation of corn cobs in the presence of SULFURIC ACID.
the Feist-Benary synthesis is the organic synthesis of classic furan.
and there is a simple synthesis methods for furans is the reaction of 1,4-diketones with PHOSPHORUS PENTOXIDE in the Paal-Knorr Synthesis. It is interesting that the Thiophene formation reaction of 1,4-diketones with Lawesson's reagent also forms furans as side products.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	intravenous	140mg/kg (140mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BLOOD: HEMORRHAGE	Journal of Pharmacology and Experimental Therapeutics. Vol. 26, Pg. 281, 1926.
dog	LDLo	oral	234mg/kg (234mg/kg)	GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS GASTROINTESTINAL: NAUSEA OR VOMITING BLOOD: HEMORRHAGE	Journal of Pharmacology and Experimental Therapeutics. Vol. 26, Pg. 281, 1926.
mouse	LC50	inhalation	120mg/m3/1H (120mg/m3)	LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	American Industrial Hygiene Association Journal. Vol. 40, Pg. 310, 1979.
mouse	LD50	intraperitoneal	7mg/kg (7mg/kg)		American Industrial Hygiene Association Journal. Vol. 40, Pg. 310, 1979.
rabbit	LDLo	oral	234mg/kg (234mg/kg)	GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS GASTROINTESTINAL: NAUSEA OR VOMITING BLOOD: HEMORRHAGE	Journal of Pharmacology and Experimental Therapeutics. Vol. 26, Pg. 281, 1926.
rat	LC50	inhalation	3398ppm/1H (3398ppm)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Hazelton Laboratories, Reports. Vol. HLA468-102, Pg. 1987,
rat	LD50	intraperitoneal	5200ug/kg (5.2mg/kg)		American Industrial Hygiene Association Journal. Vol. 40, Pg. 310, 1979.

Safety Profile

Hazard Codes of Furan (CAS NO.110-00-9): Toxic T, Highly F+
Risk Statements: 45-12-19-20/22-38-48/22-52/53-68
R45: May cause cancer.
R12: Extremely flammable.
R19: May form explosive peroxides.
R20/22: Harmful by inhalation and if swallowed.
R38: Irritating to skin.
R48/22: Harmful: danger of serious damage to health by prolonged exposure if swallowed.
R52/53: Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R68: Possible risk of irreversible effects.
Safety Statements: 53-45-61
S53: Avoid exposure - obtain special instructions before use.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S61: Avoid release to the environment. Refer to special instructions / safety data sheets.
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: OB3870000
F: 8-9-23
HazardClass: 3
PackingGroup: I

Specification

Behavior of Furan (CAS NO.110-00-9) is quite dissimilar to that of the more typical heterocyclic ethers such as tetrahydrofuran due to its aromaticity, .It is considerably more reactive than benzene in electrophilic substitution reactions, due to the electron-donating effects of the oxygen heteroatom. Examination of the resonance contributors shows the increased electron density of the ring, leading to increased rates of electrophilic substitution.