CAS No.1414-45-5,Nisin Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	1414-45-5
Name:	Nisin

Formula:	C₁₄₃H₂₃₀N₄₂O₃₇S₇
Molecular Weight:	3354.25
Synonyms:	1-Thia-4,7,10,13,16,19-hexaazacyclodocosane, cyclic peptide deriv.;1H,9H-Pyrrolo[2,1-i][1,4,7,10]thiatriazacyclotridecine, cyclic peptide deriv.;9,19-Dithia-2,5,13,16,22-pentaazabicyclo[9.9.2]docosane, cyclic peptide deriv.;Ambicin N;Delvoplus;MicroGARD MG 300;Nisaplin;Nisin(1-34);Nisitrol;Novasin;NisinA (9CI);
EINECS:	215-807-5
Density:	1.402 g/cm³
Boiling Point:	2966.771 °C at 760 mmHg
Flash Point:	1748.039 °C
Solubility:	Soluble in water
Appearance:	grey or white or light yellow powder
Hazard Symbols:	Xn
Risk Codes:	22-36/37/38
Safety:	22-24/25-36-26
PSA:	1390.67000
LogP:	3.42180

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Chemistry

Molecular Formula: C₁₄₃H₂₃₀N₄₂O₃₇S₇
Molecular Weight: 3354.07 g/mol
EINECS: 215-807-5
Classification Code: Anti-Bacterial Agents; Anti-Infective Agents; Drug / Therapeutic Agent; Food Additives; Food preservatives; Natural Product
Product Categories: Food & Feed ADDITIVES; Flavors and fragrances; PeptidesAntibiotics; Preservatives and Disinfectants; Antibacterial; Antibiotics; Antibiotics A to;Antibiotics by Application; Antibiotics N-SAntibiotics; Chemical Structure Class; Interferes with Cell Membrane Permeability (Ionophores)Spectrum of Activity; L - ZAntibiotics; Mechanism of Action
Index of Refraction: 1.635
Molar Refractivity: 857.102 cm³
Molar Volume: 2392.417 cm³
Polarizability: 339.782×10^-24 cm³
Surface Tension: 79.452 dyne/cm
Density: 1.402 g/cm³
Flash Point: 1748.039 °C
Enthalpy of Vaporization: 603.999 kJ/mol
Boiling Point: 2966.771 °C at 760 mmHg
storage temperaturte: 2-8 °C
Vapour Pressure of Nisin (CAS NO.1414-45-5): 0 mmHg at 25 °C

Uses

Nisin (CAS NO.1414-45-5) is used in processed cheese, meats, beverages, etc. during production to extend shelf life by suppressing Gram-positive spoilage and pathogenic bacteria and it is used as a food additive.

Production

Nisin is produced by fermentation using the bacterium Lactococcus lactis. Commercially, it is obtained from the culturing of Lactoccus lactis on natural substrates, such as milk or dextrose, and is not chemically synthesized.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intravenous	100mg/kg (100mg/kg)		"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 4(2), Pg. 228, 1980.
rabbit	LDLo	parenteral	2250ug/kg (2.25mg/kg)	BRAIN AND COVERINGS: MENINGEAL CHANGES BRAIN AND COVERINGS: CHANGES IN CEREBRAL SPINAL FLUID BEHAVIORAL: IRRITABILITY	British Journal of Pharmacology and Chemotherapy. Vol. 7, Pg. 438, 1952.

Safety Profile

When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes: Harmful Xn
Risk Statements: 22-36/37/38
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25-36-26
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
S36:Wear suitable protective clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
RTECS of Nisin (CAS NO.1414-45-5): QU3340000

Specification

Nisin (CAS NO.1414-45-5), its Synonyms are L-Isoleucyl-(Z)-2,3-didehydro-2-aminobutanoyl-D-cysteinyl-L-isoleucyl-2,3-didehydroalanyl-L-leucyl-L-cysteinyl-threo-3-mercapto-D-2-aminobutanoyl-L-prolylglycyl-L-cysteinyl-L-lysyl-threo-3-mercapto-D-2-aminobutanoylglycyl-L-alanyl-L-leucyl-L-methionylglycyl-L-cysteinyl-L-asparaginyl-L-methionyl-L-lysyl-threo-3-mercapto-D-2-aminobutanoyl-L-alanyl-threo-3-mercapto-D-2-aminobutanoyl-L-cysteinyl-L-histidyl-L-cysteinyl-L-seryl-L-isoleucyl-L-histidyl-L-valyl-2,3-didehydroalanyl-L-lysine cyclic (3->7),(8->11),(13->19),(23->26),(25->28)-pentakis(sulfide) ; Nisin from streptococcus lactis ; Nisin from lactococcus lactis .