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| CAS No.: | 21704-46-1 |
|---|---|
| Name: | ethyl carbamimidothioate-diethyl hydrogen phosphate (1:1) |
| Article Data: | 2 |
| Molecular Structure: | |
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| Formula: | C4 H11 O4 P . C3 H8 N2 S |
| Molecular Weight: | 258.31 |
| Synonyms: | Carbamimidothioic acid, ethyl ester, mono(diethyl phospate);diethoxyphosphinic acid; ethylsulfanylmethanimidamide;S-Ethylisothiuronium diethyl phosphate;Phosphoric acid, diethyl ester, compd. with 2-ethyl-2-thiopseudourea (1:1); |
| Boiling Point: | 200.3°C at 760 mmHg |
| Flash Point: | 74.9°C |
| Safety: | Poison by intraperitoneal route. Moderately toxic by ingestion, subcutaneous, and intramuscular routes. When heated to decomposition it emits toxic fumes of NOx, POx, and SOx. See also ESTERS and PHOSPHATES. |
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Chemistry
IUPAC Name: Diethyl hydrogen phosphate; ethyl carbamimidothioate
Molecular Formula: C4H11O4P•C3H8N2S
Molecular Weight: 258.31g/mol
Boiling Point: 200.3 °C at 760 mmHg
Flash Point: 74.9 °C
Freely Rotating Bonds: 4
Polar Surface Area: 54.57 Å2
Enthalpy of Vaporization: 48.11 kJ/mol
Vapour Pressure: 0.137 mmHg at 25°C
The Cas Register Number of Carbamimidothioic acid, ethyl ester, mono(diethyl phosphate) is 21704-46-1.The chemical synonyms of Carbamimidothioic acid, ethyl ester, mono(diethyl phosphate) (CAS NO.21704-46-1) are S-Ethylisothiuronium diethyl phosphate ; CID210823 ; LS-107705 ; Carbamimidothioic acid, ethyl ester, mono(diethyl phospate) ; Phosphoric acid, diethyl ester, compd. with 2-ethyl-2-thiopseudourea (1:1) .The molecular structure of Carbamimidothioic acid, ethyl ester, mono(diethyl phosphate) (CAS NO.21704-46-1) is 
.
Uses
Carbamimidothioic acid, ethyl ester, mono(diethyl phosphate) (CAS NO.21704-46-1) is used as pharmaceutical intermediate.
Toxicity Data With Reference
| 1. | ipr-rat LD50:113 mg/kg | FATOAO Farmakologiya i Toksikologiya (Moscow). 43 (1980),212. | ||
| 2. | orl-mus LD50:2380 mg/kg | FATOAO Farmakologiya i Toksikologiya (Moscow). 43 (1980),212. | ||
| 3. | ipr-mus LD50:680 mg/kg | FATOAO Farmakologiya i Toksikologiya (Moscow). 43 (1980),212. | ||
| 4. | scu-mus LD50:705 mg/kg | FATOAO Farmakologiya i Toksikologiya (Moscow). 43 (1980),212. | ||
| 5. | ims-mus LD50:772 mg/kg | FATOAO Farmakologiya i Toksikologiya (Moscow). 43 (1980),212. |
Safety Profile
Poison by intraperitoneal route. Moderately toxic by ingestion, subcutaneous, and intramuscular routes. When heated to decomposition it emits toxic fumes of NOx, POx, and SOx. See also ESTERS and PHOSPHATES.
Specification
Carbamimidothioic acid, ethyl ester, mono(diethyl phosphate) (CAS NO.21704-46-1) has been shown to phosphorylate other proteins in vitro including the eukaryotic initiation factor eIF-2B at Serine540 .This phosphorylation results in an inhibition of eIF-2B activity and leads to a reduction in this key regulatory step of translation. In disease states, such as diabetes, where there is elevated Carbamimidothioic acid, ethyl ester, mono(diethyl phosphate) (CAS NO.21704-46-1) could result in a reduction of translation and potentially contribute to the pathology of the disease.