Name: Dichloromethylenediphosphonic acid disodium salt
SKU: 22560-50-5

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Basic Information

Molecular Structure:
CAS No.:	22560-50-5
Name:	Dichloromethylenediphosphonic acid disodium salt

Formula:	CH₂Cl₂Na₂O₆P₂
Molecular Weight:	332.82
Synonyms:	Phosphonicacid, (dichloromethylene)bis-, disodium salt (9CI);Phosphonic acid, (dichloromethylene)di-,disodium salt (8CI);(Dichloromethylene)diphosphonate disodium;BM 06011;Bonefos;Clasteon;Clodronate disodium salt;Clodronate sodium;Clodronic aciddisodium salt;DClMDP;Dichloromethylenebisphosphonic acid disodium salt;Dichloromethylenediphosphonic acid disodium salt;Difoafonal;Diphosfonal;Disodium (dichloromethane)diphosphonate;Disodium(dichloromethylene)bisphosphonate;Disodium (dichloromethylene)diphosphonate;Disodium clodronate;Lodronate;Loron;Mebonat;Ossiten;Ostac;Sodium(dichloromethylene)diphosphonate;Sodium clodronate;
EINECS:	245-078-9
Density:	2.306g/cm3
Melting Point:	>330 °C
Boiling Point:	474.7oC at 760mmHg
Flash Point:	240.9oC
Appearance:	White solid
PSA:	140.34000
LogP:	1.30710

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Chemistry

IUPAC Name: disodium [dichloro-[hydroxy(oxido)phosphoryl]methyl]-hydroxyphosphinate (22560-50-5)
Synonyms: Clodronic acid disodium salt
Molecular Structure :
Molecular Formula : CH₂Cl₂Na₂O₆P₂
Molecular Weight : 288.86
CAS: 22560-50-5
EINECS: 245-078-9
Product Categories: All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Phosphorylating and Phosphitylating Agents
Mol File: 22560-50-5.mol
Melting point: >330°C

Uses

Sodium clodronate (22560-50-5) is used for Hypercalcaemia (too much calcium in the blood) ,some types of bone pain .

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intraperitoneal	780mg/kg (780mg/kg)	British UK Patent Application. Vol. #2096889,
mouse	LD50	intravenous	75mg/kg (75mg/kg)	British UK Patent Application. Vol. #2096889,
mouse	LD50	oral	> 2gm/kg (2000mg/kg)	British UK Patent Application. Vol. #2096889,

Safety Profile

WGK Germany : 3
RTECS: SZ7640700

Specification

1.Sodium clodronate (22560-50-5) works by binding to bone and reducing the rate at which bone is broken down.
2.When bone is broken down, calcium is lost from the bone and seeps into the blood. In cancer, there is excessive breakdown of bone which leads to high levels of calcium in the blood. As sodium clodronate prevents bone from being broken down as quickly, it reduces these high levels of calcium in the blood that are a result of cancer.
3.Store Sodium clodronate (22560-50-5) in a cool, dry place, away from direct heat and light

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Dichloromethylenediphosphonic acid disodium salt