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| CAS No.: | 24219-97-4 |
|---|---|
| Name: | MIANSERIN |
| Article Data: | 7 |
| Molecular Structure: | |
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| Formula: | C18H20 N2 |
| Molecular Weight: | 264.37 |
| Synonyms: | (?à)-Mianserin; Mianserin;Mianserine |
| Density: | 1.18g/cm3 |
| Boiling Point: | 411.3°Cat760mmHg |
| Flash Point: | 186.1°C |
| Safety: | Poison by ingestion and intraperitoneal routes. Human systemic effects by ingestion: agranulocytosis. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. |
| PSA: | 6.48000 |
| LogP: | 3.08680 |
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Chemistry
Molecule structure of Mianserine (CAS NO.24219-97-4) :
Molecular Weight: 264.3648 g/mol
Molecular Formula: C18H20N2
Density: 1.18 g/cm3
Boiling Point: 411.3 °C at 760 mmHg
Flash Point: 186.1 °C
Index of Refraction: 1.663
Molar Refractivity: 82.88 cm3
Molar Volume: 223.6 cm3
Polarizability: 32.85*10-24 cm3
Surface Tension: 53.8 dyne/cm
Enthalpy of Vaporization: 66.38 kJ/mol
Vapour Pressure: 5.65E-07 mmHg at 25 °C
XLogP3-AA: 3.4
H-Bond Acceptor: 2
Exact Mass: 264.162649
MonoIsotopic Mass: 264.162649
Topological Polar Surface Area: 6.5
Heavy Atom Count: 20
Complexity: 342
Canonical SMILES: CN1CCN2C(C1)C3=CC=CC=C3CC4=CC=CC=C42
InChI: InChI=1S/C18H20N2/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19/h2-9,18H,10-13H2,1H3
InChIKey: UEQUQVLFIPOEMF-UHFFFAOYSA-N
EINECS: 246-088-6
Product Categories: Intermediates & Fine Chemicals; Pharmaceuticals
Uses
Mianserine (CAS NO.24219-97-4) is used as serotonin receptor antagonist.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | oral | 9mg/kg/3W-I (9mg/kg) | CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE CARDIAC: OTHER CHANGES | Medical Journal of Australia. Vol. 140, Pg. 166, 1984. |
| mouse | LD50 | intraperitoneal | 130mg/kg (130mg/kg) | Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 40, Pg. 235, 1983. | |
| mouse | LD50 | oral | 365mg/kg (365mg/kg) | Drug Development Research. Vol. 3, Pg. 357, 1983. | |
| rat | LD50 | oral | 925mg/kg (925mg/kg) | Journal of International Medical Research. Vol. 13, Pg. 77, 1985. | |
| women | TDLo | oral | 1200ug/kg (1.2mg/kg) | CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) CARDIAC: CHANGE IN RATE | Human & Experimental Toxicology. Vol. 10, Pg. 383, 1991. |
| women | TDLo | oral | 25mg/kg/6W-I (25mg/kg) | BLOOD: AGRANULOCYTOSIS | British Medical Journal. Vol. 291, Pg. 1375, 1985. |
| women | TDLo | oral | 876mg/kg/2Y-I (876mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: WAKEFULNESS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Italian Journal of Neurological Sciences. Vol. 9, Pg. 167, 1988. |
Safety Profile
Poison by ingestion and intraperitoneal routes. Human systemic effects by ingestion: agranulocytosis. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
RIDADR: 3249
HazardClass: 6.1(b)
PackingGroup: III
Specification
Mianserine (CAS NO.24219-97-4) is also called 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo(c,f)pyrazino(1,2-a)azepine ; BRN 0755346 ; HSDB 7182 ; Mianserin ; Mianserina ; Mianserina [INN-Spanish] ; Mianserine [INN-French] ; Mianserinum ; Mianserinum [INN-Latin] ; Mianseryna ; Mianseryna [Polish] ; UNII-250PJI13LM ; Dibenzo(c,f)pyrazino(1,2-a)azepine, 1,2,3,4,10,14b-hexahydro-2-methyl- . Mianserine (Bolvidon, Norval, Tolvon) is a psychoactive drug of the tetracyclic antidepressant (TeCA) chemical class which is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA) and has antidepressant, anxiolytic, hypnotic, antiemetic, orexigenic, and antihistamine effects. It was previously available internationally, however in most markets it has been phased out in favor of its analogue and successor mirtazapine (Remeron). An interesting scientific fact is that upon administration, Mianserine has been shown to increase the life span of the nematode Caenorhabditis elegans by as much as 30% via dietary restriction caused by modulation of serotonin receptors in the species. But if the animals are kept in a high-food environment mianserin increases obesity and actually decreases the lifespan.