Name: SODIUM CAMPTOTHECIN
SKU: 25387-67-1

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Basic Information

Molecular Structure:
CAS No.:	25387-67-1
Name:	SODIUM CAMPTOTHECIN
Article Data:	2

Formula:	C20H18 N2 O5 . Na
Molecular Weight:	370.36
Synonyms:	21,22-Secocamptothecin-21-oicacid, monosodium salt (8CI); Indolizino[1,2-b]quinoline-7-acetic acid, a-ethyl-9,11-dihydro-a-hydroxy-8-(hydroxymethyl)-9-oxo-,monosodium salt, (S)-; Indolizino[1,2-b]quinoline-7-acetic acid, a-ethyl-9,11-dihydro-a-hydroxy-8-(hydroxymethyl)-9-oxo-,monosodium salt, (aS)- (9CI); 20(S)-Camptothecin sodium salt; Camptothecin sodium;Camptothecine sodium; NSC 100880; Sodium camptothecin
Boiling Point:	777.3°C at 760 mmHg
Flash Point:	423.9°C
Safety:	Poison by ingestion and intravenous routes. Human systemic effects by intravenous route: reduction in the number of white blood cells (leukopenia), reduction in the number of blood platelets (thrombocytopenia), and changes in blood cell count. When heated to decomposition it emits toxic fumes of NO_x and Na₂O.
PSA:	115.48000
LogP:	0.26500

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Chemistry

IUPAC Name: (2R)-2-Hydroxy-2-[8-(hydroxymethyl)-9-oxo-11H-indolizino[1,2-b]quinolin-7-yl]butanoic acid ; Sodium
Following is the structure of Camptothecin, sodium salt (CAS NO.25387-67-1):

Empirical Formula: C₂₀H₁₈N₂NaO₅
Molecular Weight: 389.3571 g/mol
Flash Point: 423.9 °C
Enthalpy of Vaporization: 118.67 kJ/mol
Boiling Point: 777.3 °C at 760 mmHg
Vapour Pressure of Camptothecin, sodium salt (CAS NO.25387-67-1): 1.96E-25 mmHg at 25 °C
Canonical SMILES: CCC(C1=C(C(=O)N2CC3=CC4=CC=CC=C4N=C3C2=C1)CO)(C(=O)O)O.[Na]
Isomeric SMILES: CC[C@@](C1=C(C(=O)N2CC3=CC4=CC=CC=C4N=C3C2=C1)CO)(C(=O)O)O.[Na]
InChI: InChI=1S/C20H18N2O5.Na/c1-2-20(27,19(25)26)14-8-16-17-12(9-22(16)18(24)13(14)10-23)7-11-5-3-4-6-15(11)21-17;/h3-8,23,27H,2,9-10H2,1H3,(H,25,26);/t20-;/m1./s1
InChIKey: PBJLMBQVBUDNJL-VEIFNGETSA-N

Toxicity Data With Reference

1.	ivn-hmn TDLo:2500 µg/kg/7D-I:BLD	CCROBU Cancer Chemotherapy Reports, Part 1. 56 (1972),515.
2.	orl-mus LD50:27 mg/kg	PMDCAY Progress in Medical Chemistry. 9 (1973),1.
3.	ivn-mus LD50:57 mg/kg	PMDCAY Progress in Medical Chemistry. 9 (1973),1.

Safety Profile

Poison by ingestion and intravenous routes. Human systemic effects by intravenous route: reduction in the number of white blood cells (leukopenia), reduction in the number of blood platelets (thrombocytopenia), and changes in blood cell count. When heated to decomposition, Camptothecin, sodium salt (CAS NO.25387-67-1) emits toxic fumes of NO_x and Na₂O.

Specification

Camptothecin, sodium salt , its cas register number is 25387-67-1. It also can be called 20(S)-Camptothecin sodium salt ;
21,22-Secocamptothecin-21-oic acid, monosodium salt ; Camptothecin sodium ; Camptothecine sodium ; and Sodium camptothecin . Its classification code are Drug / Therapeutic Agent; Human Data and Natural Product.