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| CAS No.: | 26833-87-4 |
|---|---|
| Name: | Homoharringtonine |
| Article Data: | 8 |
| Molecular Structure: | |
|
|
|
| Formula: | C29H39NO9 |
| Molecular Weight: | 545.63 |
| Synonyms: | Cephalotaxine,4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester), [3(R)]-;Homoharringtonine (8CI);CGX 635;Ceflatonin;Myelostat;NSC 141633;Omacetaxine mepesuccinate;Ephalotaxine, 4-methyl(2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester); |
| Density: | 1.33 g/cm3 |
| Melting Point: | 144-146 °C |
| Boiling Point: | 713.1 °C at 760 mmHg |
| Flash Point: | 385.1 °C |
| Appearance: | Off-white cryst. |
| Hazard Symbols: |
 T+,  Xi
|
| Risk Codes: | 26/27/28-36/37/38 |
| Safety: | 36/37/39-45-27-26 |
| Transport Information: | UN 1544 6.1/PG 2 |
| PSA: | 134.99000 |
| LogP: | 2.60430 |
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Chemistry
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Product Name: Homoharringtonine
Molecular Weight: 545.62126 [g/mol]
Molecular Formula: C29H39NO9
XLogP3: 0.8
H-Bond Donor: 2
H-Bond Acceptor: 10
storage temp.: 2-8 °C
Index of Refraction: 1.604
Molar Refractivity: 140.62 cm3
Molar Volume: 408.4 cm3
Surface Tension: 61.3 dyne/cm
Density: 1.33 g/cm3
Flash Point: 385.1 °C
Enthalpy of Vaporization: 109.46 kJ/mol
Boiling Point: 713.1 °C at 760 mmHg
Vapour Pressure: 2.41E-21 mmHg at 25 °C
Appearance: Off-white Cryst
Melting Point: 144-146 °C
Classification Code of Homoharringtonine (CAS NO.26833-87-4): Angiogenesis Inhibitors; Angiogenesis Modulating Agents; Antineoplastic Agents; Antineoplastic agents, phytogenic; Drug / Therapeutic Agent; Growth Substances; Growth inhibitors; Natural Product; Treatment of acute myeloid leukemia; Treatment of chronic myeloid leukemia; Treatment of myelodysplasia
Product Categories: Alkaloids; Chiral Reagents; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals; Cell Cycle RegulatorsCancer Research; DNA-RNA Transcription Regulators; Antitumor Agents; Apoptosis and Cell Cycle; Cell Cycle; Peptide Synthesis/Antibiotics
Uses
Homoharringtonine (CAS NO.26833-87-4) combined with some botanical drugs could induce cancer cells to resemble normal cells. It was prepared by a semi-synthetic method from Cephalotaxine, a major alkaloid of Cepahlotaxus species through the formation of a-ketoes.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD10 | intravenous | 640ug/kg (0.64mg/kg) | BEHAVIORAL: FOOD INTAKE (ANIMAL) CARDIAC: CHANGE IN RATE GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | National Cancer Institute Report. Vol. AUG1982, |
| mouse | LD50 | intraperitoneal | 3170ug/kg (3.17mg/kg) | Chinese Medical Journal Vol. 92, Pg. 175, 1979. | |
| mouse | LD50 | intravenous | 2400ug/kg (2.4mg/kg) | Journal of Ethnopharmacology. Vol. 24, Pg. 1, 1988. | |
| mouse | LD50 | oral | 7456ug/kg (7.456mg/kg) | National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986, | |
| mouse | LD50 | subcutaneous | 3948ug/kg (3.948mg/kg) | National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986, |
Safety Profile
Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx.
Safety information of Homoharringtonine (CAS NO.26833-87-4):
Hazard Codes: .gif){kind=small}
T+,.gif){kind=small}
Xi
Risk Statements: 26/27/28-36/37/38
R26/27/28: Very Toxic by inhalation, in contact with skin and if swallowed
R36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 36/37/39-45-27-26
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
S27: Take off immediately all contaminated clothing
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
RIDADR: UN 1544 6.1/PG 2
WGK Germany: 3
RTECS: FK0260000
HazardClass: 6.1(a)
PackingGroup: II
Specification
Homoharringtonine (CAS NO.26833-87-4), its Synonyms are 1-((1S,3aR,14bS)-2-Methoxy-1,5,6,8,9,14b-hexahydro-4H-cyclopenta(a)(1,3)dioxolo(4,5-h)pyrrolo(2,1-b)(3)benzazepin-1-yl) 4-methyl (2R)-2- hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate ; Ceflatonin ; Myelostat ; Omacetaxine mepesuccinate ; Omapro ; Cephalotaxine, 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester) (9CI) ; Cephalotaxine, 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester), (3(R))- (9CI) ; Cephalotaxine, 4-methyl-, 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester) ; Homoharringtonine (8CI) .