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28907-45-1

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Basic Information
CAS No.: 28907-45-1
Name: C-45
Molecular Structure:
Molecular Structure of 28907-45-1 (C-45)
Formula: C17H18 Cl N3 O . Cl H
Molecular Weight: 352.29
Synonyms: Benzo[b][1,8]naphthyridin-5(10H)-one,7-chloro-10-[3-(dimethylamino)propyl]-, monohydrochloride (8CI,9CI);10-(3-Dimethylaminopropyl)-7-chloro-5-oxobenzo[b][1,8]naphthyridinehydrochloride; C 45; C 45 (pharmaceutical); IF-C 45
Density: g/cm3
Boiling Point: 482.7°Cat760mmHg
Flash Point: 245.7°C
Safety: Poison by ingestion, intravenous, and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
PSA: 38.13000
LogP: 3.95680
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Chemistry

Molecular structure of 7-Chloro-10-(3-dimethylaminopropyl)-benzo-(b)(1,8)-5(10H)-naphthayridone hydrochloride (CAS NO.28907-45-1) is:

Product Name: 7-Chloro-10-(3-dimethylaminopropyl)-benzo-(b)(1,8)-5(10H)-naphthayridone hydrochloride
CAS Registry Number: 28907-45-1
IUPAC Name: 3-(7-chloro-5-oxobenzo[b][1,8]naphthyridin-10-yl)propyl-dimethylazanium chloride
Molecular Weight: 352.25826 [g/mol]
Molecular Formula: C17H19Cl2N3O
H-Bond Donor: 1
H-Bond Acceptor: 4
Surface Tension: 50.6 dyne/cm
Density: 1.247 g/cm3
Flash Point: 245.7 °C
Enthalpy of Vaporization: 74.76 kJ/mol
Boiling Point: 482.7 °C at 760 mmHg
Vapour Pressure: 1.79E-09 mmHg at 25°C
Related Registry Number:28907-44-0 (Parent) 
Classification Code: Drug / Therapeutic Agent

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 106mg/kg (106mg/kg)   Polish Journal of Pharmacology and Pharmacy. Vol. 27, Pg. 503, 1975.
mouse LD50 intravenous 33mg/kg (33mg/kg)   Polish Journal of Pharmacology and Pharmacy. Vol. 27, Pg. 121, 1975.
mouse LD50 oral 200mg/kg (200mg/kg)   Polish Journal of Pharmacology and Pharmacy. Vol. 27, Pg. 121, 1975.
rabbit LD50 intravenous 12mg/kg (12mg/kg)   Polish Journal of Pharmacology and Pharmacy. Vol. 27, Pg. 503, 1975.
rat LD50 intraperitoneal 105mg/kg (105mg/kg)   Polish Journal of Pharmacology and Pharmacy. Vol. 27, Pg. 503, 1975.
rat LD50 intravenous 33mg/kg (33mg/kg)   Polish Journal of Pharmacology and Pharmacy. Vol. 29, Pg. 23, 1977.
rat LD50 oral 500mg/kg (500mg/kg)   Polish Journal of Pharmacology and Pharmacy. Vol. 27, Pg. 503, 1975.
rat LD50 subcutaneous 136mg/kg (136mg/kg)   Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 34, Pg. 115, 1977.

Safety Profile

Poison by ingestion, intravenous, and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of Cl− and NOx.

Specification

 7-Chloro-10-(3-dimethylaminopropyl)-benzo-(b)(1,8)-5(10H)-naphthayridone hydrochloride , its cas register number is 28907-45-1. It also can be called C 45 ; C 45 (pharmaceutical) ; Chlorowodorku 10-gamma-dwumetyloaminopropylo-7-chlorobenzo(b)-(1,8)-naftyrydonu-5 ; Chlorowodorku 10-gamma-dwumetyloaminopropylo-7-chlorobenzo(b)-(1,8)-naftyrydonu-5 [Polish] ; IFC-45 ; IPF C-45 ; Benzo(b)(1,8)naphthyridin-5(10H)-one, 7-chloro-10-(3-(dimethylamino)propyl)-, monohydrochloride .