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CAS No.: | 302-70-5 |
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Name: | chlormethine N-oxide hydrochloride |
Molecular Structure: | |
Formula: | C5H11 Cl2 N O . Cl H |
Molecular Weight: | 208.515 |
Synonyms: | Diethylamine,2,2'-dichloro-N-methyl-, N-oxide, compd. with hydrochloric acid (7CI);Diethylamine, 2,2'-dichloro-N-methyl-, N-oxide, hydrochloride (6CI,8CI);Ethanamine, 2-chloro-N-(2-chloroethyl)-N-methyl-, N-oxide, hydrochloride (9CI);2,2'-Dichloro-N-methyldiethylamine N-oxide hydrochloride; Mechlorethamine oxidehydrochloride; Methylbis(b-chloroethyl)amine N-oxide hydrochloride; Methylbis(b-chloroethyl)amine oxidehydrochloride; Methyldi(2-chloroethyl)amine N-oxide hydrochloride; Mitomen;Mustron; N-Methyl-2,2'-dichlorodiethylamine N-oxide hydrochloride;N-Methylbis(2-chloroethyl)amine N-oxide hydrochloride; Nitrogen mustard N-oxidehydrochloride; Nitromin; Nitromin hydrochloride |
Density: | g/cm3 |
Melting Point: | 109-110° |
Boiling Point: | °Cat760mmHg |
Flash Point: | °C |
Safety: | Suspected carcinogen with experimental tumorigenic data. Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Mutation data reported. An antineoplastic agent. When heated to decomposition it emits toxic fumes of Cl− and NOx. |
PSA: | 29.43000 |
LogP: | 2.23130 |
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Chemistry informtion about 2-Chloro-N-(2-Chloroethyl)-N-Methyl Ethanamine-N-Oxide Hydrochloride (CAS NO.302-70-5) is:
IUPAC Name: 2-Chloro-N-(2-Chloroethyl)-N-Methylethanamine Oxide Hydrochloride
Synonyms: Chlormethine N-Oxide Hydrochloride ; Mechlorethaminoxyde ; Nitrogenmustardn-Oxidehydrochloride ; Mechlorethamine Oxide Hydrochloride ; Mustine N-Oxide Hydrochloride
MF: C5H12Cl3NO
MW: 208.51388
Melting Point: 109.5°C
Following is the molecular structure of 2-Chloro-N-(2-Chloroethyl)-N-Methyl Ethanamine-N-Oxide Hydrochloride (CAS NO.302-70-5) is:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
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dog | LDLo | intravenous | 4mg/kg (4mg/kg) | gastrointestinal: other changes blood: leukopenia blood: other changes | Cancer Chemotherapy Reports, Part 2. Vol. 2, Pg. 201, 1965. |
monkey | LDLo | intravenous | 8mg/kg (8mg/kg) | blood: leukopenia blood: other changes blood: other changes | Cancer Chemotherapy Reports, Part 2. Vol. 2, Pg. 201, 1965. |
mouse | LD50 | intraperitoneal | 125mg/kg (125mg/kg) | National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986, | |
rabbit | LD50 | unreported | 10mg/kg (10mg/kg) | Acta Chirurgica Scandinavica. Vol. 117, Pg. 197, 1959. | |
rat | LD50 | intraperitoneal | 79500ug/kg (79.5mg/kg) | Drugs in Japan Vol. 6, Pg. 256, 1982. | |
rat | LD50 | intravenous | 60mg/kg (60mg/kg) | "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2A, Pg. 2684, 1981. | |
rat | LD50 | oral | 60mg/kg (60mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 359, 1979. | |
rat | LD50 | subcutaneous | 76100ug/kg (76.1mg/kg) | Drugs in Japan Vol. 6, Pg. 256, 1982. | |
rat | LD50 | unreported | 83mg/kg (83mg/kg) | Acta Chirurgica Scandinavica. Vol. 117, Pg. 197, 1959. |
IARC Cancer Review: Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 9 , 1975,p. 209.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; EPA Genetic Toxicology Program.
Suspected carcinogen with experimental tumorigenic data. Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Mutation data reported. An antineoplastic agent. When heated to decomposition it emits toxic fumes of Cl− and NOx.
RIDADR: 3249
HazardClass: 6.1(a)
PackingGroup: II