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| CAS No.: | 32248-37-6 |
|---|---|
| Name: | piperocaine |
| Molecular Structure: | |
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| Formula: | C16H23NO2 |
| Molecular Weight: | 261.40 |
| Synonyms: | Benzoic acid 3-(2-methylpiperidino)propyl ester;1-Piperidinepropanol, 2-methyl-, benzoate (ester);Einecs 205-262-1;Isocaine base;Metycaine;Neothesin;Piperocaina;Piperocaina [dcit] |
| Density: | g/cm3 |
| Boiling Point: | 372.3°Cat760mmHg |
| Flash Point: | 127.6°C |
| Hazard Symbols: | 3 |
| Safety: | Poison by intravenous and intraperitoneal routes. Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic fumes of NOx. |
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Chemistry
Product Name: Piperocaine (CAS NO.32248-37-6)
Molecular Formula: C16H23NO2
Molecular Weight: 261.40g/mol
Mol File: 32248-37-6.mol
Boiling point: 372.3 °C at 760 mmHg
Flash Point: 127.6 °C
Density: 1.029 g/cm3
Surface Tension: 36.6 dyne/cm
Enthalpy of Vaporization: 61.94 kJ/mol
Vapour Pressure: 9.71E-06 mmHg at 25°C
XLogP3-AA: 3.4
H-Bond Donor: 0
H-Bond Acceptor: 3
Structure Descriptors of Piperocaine (CAS NO.32248-37-6):
IUPAC Name: 3-(2-methylpiperidin-1-yl)propyl benzoate
Canonical SMILES: CC1CCCCN1CCCOC(=O)C2=CC=CC=C2
InChI: InChI=1S/C16H23NO2/c1-14-8-5-6-11-17(14)12-7-13-19-16(18)15-9-3-2-4-10-15/h2-4,9-10,14H,5-8,11-13H2,1H3
InChIKey: YQKAVWCGQQXBGW-UHFFFAOYSA-N
Uses
Piperocaine is a local anesthetic drug used as its hydrochloride salt for infiltration and nerve blocks.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| frog | LDLo | intraspinal | 50mg/kg (50mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 45, Pg. 291, 1932. | |
| guinea pig | LDLo | subcutaneous | 268mg/kg (268mg/kg) | PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC | Anesthesiology. Vol. 1, Pg. 305, 1940. |
| mouse | LD50 | intraperitoneal | 600mg/kg (600mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 13, Pg. 27, 1956. |
| mouse | LDLo | intravenous | 26400ug/kg (26.4mg/kg) | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 4, 1950. | |
| mouse | LDLo | subcutaneous | 590mg/kg (590mg/kg) | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 4, 1950. | |
| rabbit | LD50 | intravenous | 18mg/kg (18mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 106, Pg. 37, 1952. | |
| rabbit | LDLo | intraspinal | 9500ug/kg (9.5mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 54, Pg. 137, 1935. | |
| rat | LDLo | intravenous | 17500ug/kg (17.5mg/kg) | Physiological Reviews. Vol. 12, Pg. 190, 1932. |
Safety Profile
Poison by intravenous and intraperitoneal routes. Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic fumes of NOx.
Specification
Piperocaine ,its CAS NO. is 32248-37-6,the synonyms is (2-Methylpiperidino)propyl benzoate ; 2-Methyl-1-piperidinopropanol, benzoate ; 3-Benzoxy-1-(2-methylpiperidino)propane ; 5-20-04-00079 (Beilstein Handbook Reference) ; BRN 0012274 ; Benzoyl-gamma-(2-methylpiperidino)propanol ; Isocaine (iso-sol. Co.) base ; Metycaine ; Neothesin ; gamma-(2-Methylpiperidyl)propyl benzoate ; 1-Piperidinepropanol, 2-methyl-, benzoate(ester) .