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CAS No.: | 396-01-0 |
---|---|
Name: | 2,4,7-Triamino-6-phenylpteridine |
Article Data: | 16 |
Molecular Structure: | |
Formula: | C12H11N7 |
Molecular Weight: | 253.266 |
Synonyms: | Pteridine,2,4,7-triamino-6-phenyl- (8CI);2,4,7-Triamino-6-phenylpteridine;6-Phenyl-2,4,7-triaminopteridine;Ademin;Ademine;Diren;Ditak;Diurene;Dyren;Dyrenium;Dytac;Jatropur;NSC 77625;Noridil;Pterofen;Pterophene;SKF8542;Taturil;Teriam;Teridin;Tri-Span;Triampur;Triamteren;Triteren;Urocaudal; |
EINECS: | 206-904-3 |
Density: | 1.502 g/cm3 |
Melting Point: | 316 °C |
Boiling Point: | 573.4 °C at 760 mmHg |
Flash Point: | 335.5 °C |
Solubility: | <0.1 g/100 mL at 20 °C in water |
Appearance: | Yellow solid |
Hazard Symbols: | Xn, T, F |
Risk Codes: | 22-36/37/38-36/38-23/25 |
Safety: | 26-36/37/39-45-33-24-16-7 |
Transport Information: | UN 2811 |
PSA: | 129.62000 |
LogP: | 2.57700 |
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CBNumber: CB0663775
Chemical Name: 2,4,7-Triamino-6-phenylpteridine
Molecular Formula: C12H11N7
Formula Weight: 253.26
CAS No: 396-01-0
Synonyms:6-PHENYL-PTERIDINE-2,4,7-TRIAMINE;6-PHENYL-2,4,7-PTERIDINETRIAMINE;6-PHENYL-2,4,7-TRIAMINO PTERIDINE;ADEMINE;2,4,7-TRIAMINO-6-PHENYLPTERIDINE;TRIAMTERENE;2,4,7-triamino-6-fenilpteridina;2,4,7-triamino-6-phenyl-pteridin
molecular structure:
mp :316°C
Fp :11 °C
storage temp:2-8°C
2,4,7-Triamino-6-phenylpteridine relates to pharmaceutical preparations with cardiac, particularly anti-arrhythmic activity. These preparations comprise, as an active principle, at least one compound of formula I: ##STR1## where R represents a lipophilic radical. The pharmaceutical compositions may comprise 2,4,7-Triamino-6-phenylpteridine in the presence of other pharmaceutical excipients and adjuvants.
1. | otr-ham:emb 25 mg/L | ENMUDM Environmental Mutagenesis. 8 (Suppl 6)(1986),4. | ||
2. | cyt-ham:lng 2800 µg/L | GMCRDC Gann Monograph on Cancer Research. 27 (1981),95. | ||
3. | orl-wmn TDLo:42 mg/kg/3W-I:SYS | MJAUAJ Medical Journal of Australia. 147 (1987),262. | ||
4. | orl-rat LD50:400 mg/kg | YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. 21 (1979),775. | ||
5. | ipr-rat LD50:200 mg/kg | YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. 21 (1979),775. | ||
6. | orl-mus LD50:285 mg/kg | FRXXBL French Demande Patent Document. (Commissioner of Patents and Trademarks, Washington, DC 20231) #2314719 . | ||
7. | ipr-mus LD50:249 mg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),519. | ||
8. | scu-mus LD50:620 mg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),519. |
Poison by ingestion and intraperitoneal routes. Moderately toxic by subcutaneous route. Human systemic effects: body temperature increase, hepatitis. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Harmful if swallowed
Do not breathe dust
Wear suitable protective clothing and gloves