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427-01-0

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Basic Information
CAS No.: 427-01-0
Name: (16R,19E)-19,20-Didehydro-16-[(10β,13β,21S)-23-deoxy-21,22-dihydro-11-oxa-12,24-secostrychinidin-10-yl]corynan-17-oic acid methyl ester
Molecular Structure:
Molecular Structure of 427-01-0 ((16R,19E)-19,20-Didehydro-16-[(10β,13β,21S)-23-deoxy-21,22-dihydro-11-oxa-12,24-secostrychinidin-10-yl]corynan-17-oic acid methyl ester)
Formula: C40H48N4O3
Molecular Weight: 632.92
Density: 1.32g/cm3
Melting Point: 213-214° (dec)
Boiling Point: °Cat760mmHg
Flash Point: °C
Safety: Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx.
PSA: 61.04000
LogP: 5.99640
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Chemistry

IUPAC Name: (16R,19E)-19,20-Didehydro-16-[(10β,13β,21S)-23-deoxy-21,22-dihydro-11-oxa-12,24-secostrychinidin-10-yl]corynan-17-oic acid methyl ester
Molecular Formula: C40H48N4O3
Molecular Weight: 632.92g/mol
Density: 1.32g/cm3
Melting Point: 213–214°C
Freely Rotating Bonds: 5
Polar Surface Area: 50.18 Å2
Index of Refraction: 1.695
Molar Refractivity: 183.77 cm3
Molar Volume: 478.1 cm3
Polarizability: 72.85 ×10-24 cm3
Surface Tension: 65.9 dyne/cm 
Properties: anhydrous form, crystals from absolute acetone. 
Solubility: sltly soluble in water, ether
The Cas Register Number of Geissospermine is 427-01-0.The chemical synonyms of Geissospermine (CAS NO.427-01-0) are (16R,19E)-19,20-Didehydro-16-[(10b,13b,21b)-23-deoxy-21,22-dihydro-11-oxa-12,14-secostrychnidin-10-yl]corynan-17-oic acid methyl ester ; 19,20-Didehydro-16-(15-ethyl-3a,5,5a,7,8,13a-hexahydro-4H-4,6-ethano-1H,3H-[1,3]oxazino[3,4,5-lm]pyrrolo[2,3-d]carbazol-1-yl)corynan-17-oic acidmethyl ester ; b,17-Epoxy-a-(3-ethylidene-1,2,3,4,6,7,12,12b-octahydroindole[2,3-a]quinolizin-2-yl)-curan-1-propanoic acid methyl ester ; Geissospermine .The molecular structure of Geissospermine (CAS NO.427-01-0) is.

Uses

  Geissospermine (CAS NO.427-01-0) is used as cardiovascular preparation .

Toxicity Data With Reference

1.    

orl-mus LD50:450 mg/kg

     APFRAD    Annales Pharmaceutiques Francaises. 19 (1961),104.
2.    

ipr-mus LD50:125 mg/kg

     APFRAD    Annales Pharmaceutiques Francaises. 19 (1961),104.
3.    

scu-mus LD50:150 mg/kg

     APFRAD    Annales Pharmaceutiques Francaises. 19 (1961),104.
4.    

ivn-mus LD50:20 mg/kg

     APFRAD    Annales Pharmaceutiques Francaises. 19 (1961),104.

Safety Profile

Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx.