CAS No.501-30-4,Kojic acid Suppliers,MSDS download

Products Categories

Pharmaceutical (392)
Others (78)
Organic Chemicals (71)
Reagent (13)
Food Additives (10)
Plant Extract (9)
Catalyst and Auxiliary (9)
Synthetic Flavours & Fragrances (3)
Materials (3)
Basic Inorganic Chemicals (3)
Agrochemicals (1)

Basic Information

Molecular Structure:
CAS No.:	501-30-4
Name:	Kojic acid
Article Data:	18

Formula:	C₆H₆O₄
Molecular Weight:	142.111
Synonyms:	Kojic acid(whitening agent in cosmetic);3-O-Ethyl ascorbic acid;5-Hydroxy-2-hydroxymethyl-4H-4-pyranone;4H-Pyran-4-one,5-hydroxy-2-(hydroxymethyl)-;5-Hydroxy-2-hydroxymethyl-4-pyrone;5-Hydroxy-2-(hydroxymethyl)-4-pyrone;5-18-02-00516 (Beilstein Handbook Reference);5-hydroxy-2-(hydroxymethyl)pyran-4-one;5-Hydroxy-2-(hydroxymethyl)-4H-pyran-4-one;2-(Hydroxymethyl)-5-hydroxy-4H-pyran-4-one;4H-Pyran-4-one, 5-hydroxy-2- (hydroxymethyl)-;
EINECS:	207-922-4
Density:	1.542 g/cm³
Melting Point:	152-155 °C
Boiling Point:	401.7 °C at 760 mmHg
Flash Point:	179.9 °C
Solubility:	Soluble in water
Appearance:	Tan powder
Hazard Symbols:	Xn
Risk Codes:	40-68
Safety:	22-24/25-36/37-36
PSA:	70.67000
LogP:	-0.16230

Synthetic route

: 26209-93-8
5-acetoxy-2-acetoxymethyl-4H-pyran-4-one

: 501-30-4
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

Conditions

Conditions	Yield
With sodium methylate In methanol for 1h;	95%
With methanol; ammonia

: 7559-81-1
chlorokojic acid

: 67-64-1
acetone

A: 644-46-2
allomaltol

B: 501-30-4
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

C: 16065-34-2
iodokojic acid

D: 3019-04-3
iodoacetone

Conditions

Conditions	Yield
With sodium iodide at 45℃; for 24h; Substitution;	A n/a B n/a C 78% D n/a

...Expand

: 5-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy)-2-(((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)oxy)methyl)-4H-pyran-4-one

: 501-30-4
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

Conditions

Conditions	Yield
With silica gel In methanol at 60℃; for 3h; Inert atmosphere;	70%

: 2-keto-D-glucose

: 501-30-4
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

Conditions

Conditions	Yield
Stage #1: 2-keto-D-glucose With sodium acetate; acetic anhydride In N,N-dimethyl-formamide for 23h; Stage #2: With sodium methylate In methanol for 1h;	20%

: 58-86-6
D-xylose

: 501-30-4
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

Conditions

Conditions	Yield
With Aspergillus oryzae Bei der Vergaerung;

: 69-65-8
mannitol

A: 501-30-4
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

: 57-48-7, 87-79-6, 87-81-0, 551-68-8, 3615-39-2, 3615-56-3, 6035-50-3, 7776-48-9, 16354-64-6, 17598-81-1, 17598-82-2, 23140-52-5, 30237-26-4, 65732-90-3, 73952-10-0, 73952-11-1, 139686-85-4
fructose

Conditions

Conditions	Yield
bei der Einw.verschiedener Essigbakterien;

: 50-70-4
D-sorbitol

: 501-30-4
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

Conditions

Conditions	Yield
durch Aspergillus oryzae;

: 608-66-2
D-galactitol

: 501-30-4
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

Conditions

Conditions	Yield
bei der Einw.von Aspergillus oryzae;

: 5328-37-0
L-arabinose

: 501-30-4
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

Conditions

Conditions	Yield
With Aspergillus oryzae Bei der Vergaerung;

: 56-81-5
glycerol

: 501-30-4
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

Conditions

Conditions	Yield
With aspergillus glaucus Bei der Vergaerung;
bei der Einw.von Aspergillus glaucus;

Raw Materials

50-70-4

87-89-8

608-66-2

26209-93-8

69-65-8

58-86-6

56-81-5

50-99-7

Downstream Products

644-46-2

496-63-9

Total:264 Page 1 of 7 1 2 3 4 5 6 …7 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 501-30-4

Chemistry

Molecular Formula: C₆H₆O₄
Molecular Weight: 142.11
EINECS: 207-922-4
Index of Refraction: 1.606
Density: 1.542 g/cm³
Flash Point: 179.9 °C
Enthalpy of Vaporization: 75.44 kJ/mol
Boiling Point: 401.7 °C at 760 mmHg
Vapour Pressure: 4.01E-08 mmHg at 25 °C
Melting point: 152-155 °C
Water solubility: Soluble
Appearance: Tan powder
Structure of Kojic acid (CAS NO.501-30-4):

IUPAC Name: 5-Hydroxy-2-(hydroxymethyl)pyran-4-one
Product Category of Kojic acid (CAS NO.501-30-4): Heterocycles;Plant Oils, Toxins, Phenolic Acids & Derivatives

Uses

Kojic acid (CAS NO.501-30-4) can be used in food and cosmetics to preserve or change colors of substances. On cut fruits it is used to prevent oxidative browning, in seafood to preserve pink and red colors, and in cosmetics to lighten skin.

Toxicity Data With Reference

1.	mmo-sat 1 mg/plate	MUREAV Mutation Research. 67 (1979),367.
2.	mma-sat 4 mg/plate	JTSCDR Journal of Toxicological Sciences. 7 (1982),255.
3.	ivn-rat LDLo:1000 mg/kg	85ERAY Antibiotics: Origin, Nature, and Properties. 3 (1978),1755.
4.	orl-mus LDLo:4 g/kg	NATUAS Nature. 155 (1945),302.
5.	ipr-mus LD50:250 mg/kg	85GDA2 CRC Handbook of Antibiotic Compounds, Volumes 1-9. 5 (1981),393.
6.	scu-mus LDLo:1500 mg/kg	NATUAS Nature. 155 (1945),302.
7.	ivn-mus LDLo:1500 mg/kg	NATUAS Nature. 155 (1945),302.
8.	ivn-dog LDLo:1000 mg/kg	85ERAY Antibiotics: Origin, Nature, and Properties. 3 (1978),1755.
9.	ivn-rbt LDLo:1000 mg/kg	85ERAY Antibiotics: Origin, Nature, and Properties. 3 (1978),1755.

Consensus Reports

EPA Genetic Toxicology Program.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion, intravenous, and subcutaneous routes. Mutation data reported. When heated to decomposition it emits acrid smoke and fumes.
Hazard Codes: Harmful Xn
Risk Statements:
R40:Limited evidence of a carcinogenic effect
R68 :Possible risk of irreversible effects
Safety Statements:
S22:Do not breathe dust
S24/25:Avoid contact with skin and eyes
S36/37:Wear suitable protective clothing and gloves
S36 :Wear suitable protective clothing
WGK Germany: 3

Specification

Kojic acid , its cas register number is 501-30-4. It also can be called 5-Hydroxy-2-(hydroxymethyl)-4H-pyran-4-one ; and 5-Hydroxy-2-hydroxymethyl-4-pyrone . It is a mild inhibitor of the formation of pigment in plant and animal tissues. It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Then you have the ingesting of the product: Wash mouth out with water, and get medical aid immediately. Notes to physician: Treat supportively and symptomatically.
In addition, Kojic acid (CAS NO.501-30-4) is not compatible with strong oxidizing agents, and you must not take it with incompatible materials. And also prevent it to broken down into hazardous decomposition products: carbon monoxide, carbon dioxide.