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| CAS No.: | 51-71-8 |
|---|---|
| Name: | Phenelzine |
| Molecular Structure: | |
|
|
|
| Formula: | C8H12 N2 |
| Molecular Weight: | 136.197 |
| Synonyms: | Hydrazine,phenethyl- (6CI,8CI); 1-(2-Phenethyl)hydrazine; 1-(2-Phenylethyl)hydrazine;1-Hydrazino-2-phenylethane; 2-Phenylethylhydrazine; Phenalzine; Phenelzine;Phenethylhydrazine; Phenylethylhydrazine; W 1544; b-Phenylethylhydrazine |
| EINECS: | 200-117-9 |
| Density: | 1.01 g/cm3 |
| Melting Point: | 25°C |
| Boiling Point: | 281.4 °C at 760 mmHg |
| Flash Point: | 143.7 °C |
| Hazard Symbols: |
 Xi
|
| Safety: | Poison by ingestion, intraperitoneal, and subcutaneous routes. Human systemic effects by ingestion: ataxia, somnolence. An experimental teratogen. Experimental reproductive effects. Mutation data reported. Used as an antidepressant. When heated to decomposition it emits toxic fumes of NOx. |
| PSA: | 38.05000 |
| LogP: | 1.78360 |
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Chemistry
Chemistry informtion about 2-Phenylethylhydrazine (CAS NO.51-71-8) is:
IUPAC Name: Phenethylhydrazine
Synonyms: Asinex-Reag Bas 07650440 ; Beta-Phenylethylhydrazine ; 2-Phenelzine ; (2-Phenyl-Ethyl)-Hydrazine ; Phenethyl Hydrazine ; Phenelzine ; (2-Phenylethyl)-Hydrazin ; 1-(2-Phenylethyl)Hydrazine
MF: C8H12N2
MW: 136.19
EINECS: 200-117-9
Density: 1.01 g/cm3
Flash Point: 143.7 °C
Boiling Point: 281.4 °C at 760 mmHg
Vapour Pressure: 0.00358 mmHg at 25°C
Enthalpy of Vaporization: 52.02 kJ/mol
Following is the molecular structure of 2-Phenylethylhydrazine (CAS NO.51-71-8) is:
Uses
2-Phenylethylhydrazine (CAS NO.51-71-8) is used primarily in the treatment of major depressive disorder (MDD). Patients with depressive symptomology characterized as "atypical", "nonendogenous", and/or "neurotic", have been reported to respond particularly well to phenelzine. The medication has also been found to be useful in patients who do not respond favorably to first and second-line treatments for depression, or are said to be "treatment-resistant". In addition to being a recognized treatment for major depressive disorder, it has been found in studies to be effective in treating dysthymia, bipolar depression (BD), panic disorder (PD), social anxiety disorder (SAD), bulimia, and post-traumatic stress disorder (PTSD).
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| child | TDLo | oral | 7500ug/kg (7.5mg/kg) | behavioral: ataxia behavioral: somnolence (general depressed activity) | American Journal of Diseases of Children. Vol. 130, Pg. 507, 1976. |
| mouse | LD50 | intraperitoneal | 135mg/kg (135mg/kg) | Farmakologiya i Toksikologiya Vol. 32, Pg. 526, 1969. | |
| mouse | LD50 | oral | 130mg/kg (130mg/kg) | Biochemical Pharmacology. Vol. 17, Pg. 369, 1968. | |
| mouse | LD50 | subcutaneous | 122mg/kg (122mg/kg) | Farmakologiya i Toksikologiya Vol. 37, Pg. 651, 1974. | |
| women | LDLo | oral | 30mg/kg (30mg/kg) | lungs, thorax, or respiration: acute pulmonary edema liver: fatty liver degeration | Journal of Analytical Toxicology. Vol. 19, Pg. 265, 1995. |
| women | TDLo | oral | 39600ug/kg/44 (39.6mg/kg) | behavioral: "hallucinations, distorted perceptions" behavioral: toxic psychosis behavioral: muscle contraction or spasticity) | Journal of Clinical Psychiatry. Vol. 48, Pg. 340, 1987. |
Safety Profile
Poison by ingestion, intraperitoneal, and subcutaneous routes. Human systemic effects by ingestion: ataxia, somnolence. An experimental teratogen. Experimental reproductive effects. Mutation data reported. Used as an antidepressant. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes:
Xi
Specification
2-Phenylethylhydrazine (CAS NO.51-71-8) is an irreversible and nonselective and monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class which is used as an antidepressant and anxiolytic. Along with tranylcypromine and isocarboxazid, phenelzine is one of the few nonselective MAOIs still in widespread clinical use. 2-Phenylethylhydrazine and the other MAOIs are typically considered to be significantly more effective against clinical depression in comparison to more mainstream antidepressants like the selective serotonin reuptake inhibitors (SSRIs), but are usually reserved only as a last resort due to their prominent side effects and potentially hazardous food and drug interactions. Notably, phenelzine has shown unique efficacy in treating anxiety disorders, likely due to its actions on GABA concentrations.