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| CAS No.: | 541-25-3 |
|---|---|
| Name: | lewisite |
| Article Data: | 1 |
| Molecular Structure: | |
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| Formula: | C2H2 As Cl3 |
| Molecular Weight: | 207.318 |
| Synonyms: | Arsine,dichloro(2-chlorovinyl)- (7CI,8CI); Arsonous dichloride, (2-chloroethenyl)-(9CI); Lewisite (6CI); 2-Chlorovinyldichloroarsine; Chlorovinylarsinedichloride; Dichloro(2-chlorovinyl)arsine; Dichloro(b-chlorovinyl)arsine; Lewisite (arsenic compound);Lewisite I |
| Density: | g/cm3 |
| Melting Point: | 0.1 °C |
| Boiling Point: | 203°Cat760mmHg |
| Flash Point: | 84.4°C |
| Solubility: | 0.5g/L(20 oC) |
| Safety: | A human poison by inhalation. Poison experimentally by inhalation, skin contact, subcutaneous, intraperitoneal, and intravenous routes. An experimental teratogen. A blistering-type military poison. Lewisite is absorbed through skin; as little as 2 mL on the skin can cause death. Has a delayed action similar to distilled mustard gas. This gas exhibits a systemic poisoning effect on humans. When heated to decomposition it emits toxic fumes of Cl− and As. See also ARSENIC COMPOUNDS. |
| PSA: | 0.00000 |
| LogP: | 2.24390 |
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Chemistry
IUPAC Name: Dichloro-[(E)-2-chloroethenyl]arsane
Synonyms of Chlorovinylarsine dichloride (CAS NO.541-25-3) : [(E)-2-Chloroethenyl]arsonous dichloride ; 2-Chlorovinyldichloroarsine ; Arsine, (2-chlorovinyl)dichloro- ; Arsonous dichloride, N-[(E)-2-chloroethenyl]-
CAS NO: 541-25-3
Molecular Formula:C2H2AsCl3
Molecular Weight :207.3179
Molecular Structure :.png)
Flash Point: 84.4 °C
Enthalpy of Vaporization: 42.13 kJ/mol
Boiling Point: 203 °C at 760 mmHg
Vapour Pressure: 0.405 mmHg at 25°C
Uses
Chlorovinylarsine dichloride (CAS NO.541-25-3)
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LCLo | inhalation | 50gm/m3/30M (50000mg/m3) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: OTHER CHANGES | Reviews of Environmental Contamination and Toxicology. Vol. 110, Pg. 75, 1989. |
| dog | LD50 | intravenous | 2mg/kg (2mg/kg) | National Technical Information Service. Vol. PB158-508, | |
| dog | LD50 | skin | 15mg/kg (15mg/kg) | Journal of Pathology and Bacteriology. Vol. 58, Pg. 411, 1946. | |
| dog | LD50 | subcutaneous | 2mg/kg (2mg/kg) | Journal of Pathology and Bacteriology. Vol. 58, Pg. 411, 1946. | |
| domestic animals - goat/sheep | LD50 | skin | 10mg/kg (10mg/kg) | National Technical Information Service. Vol. PB158-508, | |
| guinea pig | LD50 | skin | 12mg/kg (12mg/kg) | Journal of Pathology and Bacteriology. Vol. 58, Pg. 411, 1946. | |
| guinea pig | LD50 | subcutaneous | 1mg/kg (1mg/kg) | Journal of Pathology and Bacteriology. Vol. 58, Pg. 411, 1946. | |
| guinea pig | LDLo | intraperitoneal | 2mg/kg (2mg/kg) | National Technical Information Service. Vol. PB158-508, | |
| human | LCLo | inhalation | 6ppm/30M (6ppm) | National Technical Information Service. Vol. PB214-270, | |
| human | LDLo | skin | 37600ug/kg (37.6mg/kg) | EHP, Environmental Health Perspectives. Vol. 98, Pg. 259, 1992. | |
| mouse | LD50 | skin | 12mg/kg (12mg/kg) | National Technical Information Service. Vol. PB158-508, | |
| rabbit | LD50 | intravenous | 500ug/kg (0.5mg/kg) | Journal of Pathology and Bacteriology. Vol. 58, Pg. 411, 1946. | |
| rabbit | LD50 | skin | 4mg/kg (4mg/kg) | Biochemical Journal. Vol. 41, Pg. 325, 1947. | |
| rabbit | LD50 | subcutaneous | 2mg/kg (2mg/kg) | Journal of Pathology and Bacteriology. Vol. 58, Pg. 411, 1946. | |
| rat | LD50 | oral | 50mg/kg (50mg/kg) | EHP, Environmental Health Perspectives. Vol. 98, Pg. 259, 1992. | |
| rat | LD50 | skin | 15mg/kg (15mg/kg) | National Technical Information Service. Vol. PB158-508, | |
| rat | LD50 | subcutaneous | 1mg/kg (1mg/kg) | Journal of Pathology and Bacteriology. Vol. 58, Pg. 411, 1946. |
Consensus Reports
Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program. EPA Extremely Hazardous Substances List. Arsenic and its compounds are on the Community Right-To-Know List.
Safety Profile
A human poison by inhalation. Poison experimentally by inhalation, skin contact, subcutaneous, intraperitoneal, and intravenous routes. An experimental teratogen. A blistering-type military poison. Lewisite is absorbed through skin; as little as 2 mL on the skin can cause death. Has a delayed action similar to distilled mustard gas. This gas exhibits a systemic poisoning effect on humans. When Chlorovinylarsine dichloride (CAS NO.541-25-3) is heated to decomposition, it emits toxic fumes of Cl− and As. See also ARSENIC COMPOUNDS.
RIDADR 2927
HazardClass 6.1(a)
PackingGroup I