CAS No.57-13-6,Urea Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	57-13-6
Name:	Urea
Article Data:	996

Formula:	CH₄N₂O
Molecular Weight:	60.0556
Synonyms:	Carbamide;Carbonyl diamide;Carbonyldiamine;Diaminomethanal;Diaminomethanone;Prespersion, 75 urea;Urea-13C;Ureacin-20;Urepearl;
EINECS:	200-315-5
Density:	1.32 g/cm³
Melting Point:	131-135 °C
Boiling Point:	196.611 °C at 760 mmHg
Flash Point:	72.708 °C
Solubility:	in water: 51.8 g/100 ml (20 °C), 54.5 g/100ml (25 °C), 71.7 g/100 ml (60 °C), 95.0 g/100 ml (120 °C)
Appearance:	white solid
Hazard Symbols:	Xi,Xn
Risk Codes:	36/37/38-40
Safety:	26-36-24/25
PSA:	69.11000
LogP:	0.42440

Synthetic route

: 22981-32-4
ammonium cyanate

: 57-13-6
urea

Conditions

Conditions	Yield
In ethanol at 32°C;	100%
In ethanol at 32°C;	100%
In water Kinetics; izomerization; equil. react.;

: 868-84-8
S,S-dimethyl dithiocarbonate

: 57-13-6
urea

Conditions

Conditions	Yield
With ammonia; water at 60℃; for 2h;	100%

: 201230-82-2
carbon monoxide

: 7664-41-7
ammonia

: 7704-34-9
sulfur

A: 7783-06-4
hydrogen sulfide

B: 57-13-6
urea

Conditions

Conditions	Yield
In methanol; water molar ratio of CO:S = 1.36; 35 min; at 110°C; 60% excess of NH3; 75% CH3OH;	A n/a B 96.2%
In methanol; water molar ratio of NH3:S:CO = 1.4 : 1 : 1.36; 35 min; at 110°C; 54% CH3OH;	A n/a B 96.2%
In methanol; water molar ratio of NH3:S:CO = 1.4 : 1 : 1.36; 35 min; at 110°C; 54% CH3OH;	A n/a B 96.3%

...Expand

: 17356-08-0
thiourea

: 57-13-6
urea

Conditions

Conditions	Yield
With bismuth(III) nitrate In acetonitrile for 0.25h; Heating;	96%
With Oxone for 0.0833333h;	96%
With 3-carboxypyridinium chlorochromate In acetonitrile for 0.0333333h; Product distribution; Further Variations:; Reagents; Temperatures; without microwave irradiation; solvent-free; microwave irradiation;	95%

: 381-73-7
Difluoroacetic acid

: 20017-67-8
3,3-diphenylpropan-1-ol

A: difluoroacetic acid, O-(3,3-diphenyl-propyl) ester

B: 57-13-6
urea

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In diethyl ether at 0 - 20℃;	A 96% B n/a

...Expand

: 556-89-8
nitrourea

: 7664-41-7
ammonia

A: 57-13-6
urea

B: 7782-94-7
nitramine

Conditions

Conditions	Yield
In ammonia at -33°C;	A 91% B n/a

...Expand

: 67969-82-8
tetrafluoroboric acid diethyl ether

: F6P(1-)*C25H43Fe2N2OS2(1+)

: 75-05-8
acetonitrile

A: F6P(1-)*C26H44Fe2N4S2(2+)*BF4(1-)

B: 57-13-6
urea

Conditions

Conditions	Yield
In acetone at 20℃; for 2h; Inert atmosphere; Schlenk technique;	A 90% B 90%

...Expand

: 124-41-4
sodium methylate

: 80981-23-3
4-ureidocarbonylpyrazole

A: 51105-90-9
methyl pyrazole-4-carboxylate

B: 57-13-6
urea

Conditions

Conditions	Yield
In methanol for 2h; Heating;	A 89% B n/a

...Expand

: 463-58-1
carbon oxide sulfide

: 7664-41-7
ammonia

A: 7783-06-4
hydrogen sulfide

B: 57-13-6
urea

Conditions

Conditions	Yield
1.5-fold molar excess of NH3; at 105°C;	A n/a B 88%
In ethanol at a temp. near the m.p. of urea; using abs. ethanol;	A n/a B 76%
In ammonia at a temp. near the m.p. of urea;	A n/a B 64%

...Expand

: 13463-40-6
iron pentacarbonyl

: 7664-41-7
ammonia

A: 2NH4(1+)*{Fe(CO)4}(2-)=(NH4)2{Fe(CO)4}

B: 57-13-6
urea

Conditions

Conditions	Yield
With ammonium chloride In ammonia at exclusion of light, air and moisture; 20°C; 5 d;	A n/a B 85%
In ammonia at exclusion of light, air and moisture; 20°C; 5 d;	A n/a B 77%
In ammonia at exclusion of light, air and moisture; 20°C; 1 d;	A n/a B 31%
In ammonia at exclusion of light, air and moisture; 20°C; 14 d;	A n/a B >99

...Expand

Raw Materials

65-71-4

107-35-7

7732-18-5

75-13-8

3644-72-2

1912-24-9

64-17-5

97-59-6

Downstream Products

57-41-0

56-33-7

Total:632 Page 1 of 17 1 2 3 4 5 6 …17 Next>>

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Specification

Urea is a weak base and a organic compound with the formula CH₄N₂O. Urea is also called as carbamide which is white crystalline powder. It is highly soluble in water and non-toxic. Urea reacts with azo and diazo compounds to generate toxic gases, and reacts with strong reducing agents to form flammable gases. Urea should be sealed and stored in cool and dry place.

Physical properties about Urea are: (1)ACD/LogP: -1.66; (2)ACD/LogD (pH 5.5): 1.66; (3)ACD/LogD (pH 7.4): -1.66; (4)ACD/BCF (pH 5.5): 1.00; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5): 2.98; (7)ACD/KOC (pH 7.4): 2.98; (8)#H bond acceptors: 3; (9)#H bond donors: 4; (10)Index of Refraction: 1.469; (11)Molar Refractivity: 13.782 cm³; (12)Molar Volume: 49.517 cm3; (13)Polarizability: 5.464 10-24cm³; (14)Surface Tension: 55.3680000305176; (15)dyne/cm Density: 1.213 g/cm³; (16)Flash Point: 72.708 °C; (17)Enthalpy of Vaporization: 43.281 kJ/mol; (18)Boiling Point: 196.611 °C at 760 mmHg; (19)Vapour Pressure: 0.395000010728836 mmHg at 25°C

Preparation of Urea: The synthesis of Urea from an inorganic precursor was an important milestone in the development of organic chemistry, as it showed for the first time that a molecule found in living organisms could be synthesized in the lab without biological starting materials. In addition, Urea can be prepared by treating silver isocyanate with ammonium chloride.

AgNCO + NH₄Cl → (NH₂)₂CO + AgCl

The Urea can also be prepared by ammonia and carbon dioxide. The mixture reacts to generate ammonium carbamate. Finally, you can gain Urea through dehydration.

NH₃ + CO₂ → H₂NCONH₄ → H₂NCONH₂

Meanwhile, the Urea can also be prepared by calcium cyanamide and sulfuric acid. The mixture reacts and generates cyanamide. After that, it reacts with H₂O. Via decoloration and recrystallization, you can gain Urea.

CaNCN + H₂SO₄ → NH₂CN + CaSO₄NH₂CN + H₂O → NH₂CONH₂

Uses of Urea : Urea is used as a nitrogen-release fertilizer in agriculture. In chemical industry it is a raw material for the manufacture of many important chemicals, such as: various plastics, especially the urea-formaldehyde resins; various adhesives, such as urea-formaldehyde or the urea-melamine-formaldehyde used in marine plywood ; potassium cyanate, another industrial feedstock; Urea nitrate, an explosive. And also Urea is used in topical dermatological products to promote rehydration of the skin. If covered by an occlusive dressing, 40% Urea preparations may also be used for nonsurgical debridement of nails. This Urea is also used as an earwax removal aid.

When you are using Urea, please be cautious about it: Urea is irritating to eyes, respiratory system and skin. And limited evidence of a carcinogenic effect. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Moreover, you should wear suitable protective clothing to avoid contact Urea with skin and eyes.

People can use the following data to convert to the molecule structure of Urea:
(1)SMILES: C(=O)(N)N
(2)InChI: InChI=1/CH4N2O/c2-1(3)4/h(H4,2,3,4)
(3)InChIKey: XSQUKJJJFZCRTK-UHFFFAOYAF

Toxicity of Urea:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	intravenous	3gm/kg (3000mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1353, 1935.
dog	LDLo	subcutaneous	3gm/kg (3000mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1353, 1935.
domestic animals - goat/sheep	LDLo	oral	511mg/kg (511mg/kg)	BEHAVIORAL: TETANY GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: DYSPNEA	American Journal of Physiology. Vol. 153, Pg. 41, 1948.
frog	LDLo	subcutaneous	600mg/kg (600mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1353, 1935.
mouse	LD50	intravenous	4600mg/kg (4600mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ANTIPSYCHOTIC	Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 749, 1977.
mouse	LD50	oral	11gm/kg (11000mg/kg)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(12), Pg. 53, 1987.
mouse	LD50	subcutaneous	9200mg/kg (9200mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ANTIPSYCHOTIC	Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 749, 1977.
mouse	LDLo	intraperitoneal	6608mg/kg (6608mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA	Journal of Pharmacology and Experimental Therapeutics. Vol. 57, Pg. 19, 1936.
pigeon	LDLo	subcutaneous	14800mg/kg (14800mg/kg)		"Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
rabbit	LDLo	intravenous	4800mg/kg (4800mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1353, 1935.
rabbit	LDLo	oral	10gm/kg (10000mg/kg)	BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI BLOOD: HEMORRHAGE	Japanese Journal of Veterinary Science. Vol. 15, Pg. 125, 1953.
rabbit	LDLo	subcutaneous	3gm/kg (3000mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1353, 1935.
rat	LD50	intraperitoneal	> 5gm/kg (5000mg/kg)		Naunyn-Schmiedebergs Archiv fuer Pharmakologie und Experimentelle Pathologie. Vol. 257, Pg. 296, 1967.
rat	LD50	intratracheal	567mg/kg (567mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 30(3), Pg. 43, 1986.
rat	LD50	intravenous	5300mg/kg (5300mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: ANTIPSYCHOTIC BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 749, 1977.
rat	LD50	oral	8471mg/kg (8471mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 51(6), Pg. 8, 1986.
rat	LD50	subcutaneous	8200mg/kg (8200mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ANTIPSYCHOTIC	Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 749, 1977.

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