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Basic Information
CAS No.: 60-70-8
Name: veratramine
Article Data: 5
Molecular Structure:
Molecular Structure of 60-70-8 (veratramine)
Formula: C27H39 N O2
Molecular Weight: 409.612
Synonyms: Veratraman-3,23-diol,14,15,16,17-tetradehydro-, (3b,23b)-; Veratramine (7CI,8CI);1H-Benzo[a]fluorene, veratraman-3,23-diol deriv.; NSC 17821; NSC 23880
Density: 1.14g/cm3
Melting Point: 122-1240C
Boiling Point: 565°C at 760 mmHg
Flash Point: 86.2°C
Safety: Poison by ingestion, intravenous, and subcutaneous routes. An experimental teratogen. When heated to decomposition it emits toxic fumes of NOx.
PSA: 52.49000
LogP: 4.92330
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    Hight Quality Cas No.: 60-70-8 Formula: C27H39NO2 Mol Weight: 409.614 Botanical Source: Veratrum album var. grandiflorum and several other Veratrum spp Physical Description: Type of Compound: Alkaloids Analysis Method: HPLC-DAD or/and HPLC

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Chemistry

IUPAC Name: (2S,3R,5S)-2-[(1S)-1-[(3S,6aR,11aS,11bR)-3-hydroxy-10,11b-dimethyl-1,2,3,4,6,6a,11,11a-octahydrobenzo[a]fluoren-9-yl]ethyl]-5-methylpiperidin-3-ol
Synonyms: Veratramine ; Vreaframine ; (3b,23b)-14,15,16,17-Teradehydroveratraman-3,23-diol ; (3,23)-14,15,16,17-Teradehydroveratraman-3,23-diol
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
Molecular Formula of Veratramine (CAS NO.60-70-8) : C27H39NO2
Molecular Weight: 409.6041 g/mol
Structure of  Veratramine (CAS NO.60-70-8) :

Index of Refraction: 1.601
Surface Tension: 50.5 dyne/cm
Density: 1.14 g/cm3
Flash Point: 86.2 °C
Enthalpy of Vaporization: 89.29 kJ/mol
Boiling Point: 565 °C at 760 mmHg
Vapour Pressure: 1.33E-13 mmHg at 25°C 
Melting point: 122-1240°C
Appearance: White Solid
 

Uses

 Veratramine (CAS NO.60-70-8) is useful as signal transduction inhibitor for treating tumors.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 3100ug/kg (3.1mg/kg)   Cesko-Slovenska Farmacie. Vol. 2, Pg. 418, 1953.
 
mouse LD50 subcutaneous 4500ug/kg (4.5mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 89, 1955.
 
rabbit LDLo oral 33mg/kg (33mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR		 Teratology, The International Journal of Abnormal Development. Vol. 3, Pg. 175, 1970.
 

Safety Profile

Poison by ingestion, intravenous, and subcutaneous routes. An experimental teratogen. When heated to decomposition  Veratramine (CAS NO.60-70-8) emits toxic fumes of NOx.