Name: trifluperidol
SKU: 749-13-3

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Basic Information

Molecular Structure:
CAS No.:	749-13-3
Name:	trifluperidol
Article Data:	4

Formula:	C22H23 F4 N O2
Molecular Weight:	409.424
Synonyms:	Butyrophenone,4'-fluoro-4-[4-hydroxy-4-(a,a,a-trifluoro-m-tolyl)piperidino]- (6CI,7CI,8CI);4'-Fluoro-4-[4-hydroxy-4-(a,a,a-trifluoro-m-tolyl)piperidino]butyrophenone;Flumoperone; McN-JR 2498; NSC 170978; P 459; Psicoperidol; R 2498;Trifluoperidol; Trifluperidol; Trifluperol; Triperidol; Trisedil; p-Fluoro-g-[4-hydroxy-4-(3-trifluoromethylphenyl)piperidino]butyrophenone
Density:	1.26g/cm³
Boiling Point:	535.7°C at 760 mmHg
Flash Point:	277.8°C
Safety:	Poison by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of F⁻ and NO_x. See also FLUORIDES and TRIFLUPERIDOL HYDROCHLORIDE.
PSA:	40.54000
LogP:	4.72890

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Chemistry

IUPAC Name: 1-(4-Fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]-1-piperidyl]butan-1-one
Synonyms of Trifluperidol (CAS NO.749-13-3) : 1-Butanone, 1-(4-fluorophenyl)-4-(4-hydroxy-4-(3-(trifluoromethyl)phenyl)-1-piperidinyl)- ; 4'-Fluoro-4-(4-hydroxy-4-(alpha,alpha,alpha-trifluoro-m-tolyl)piperidino butyrophenone ; Flumoperone ; Psicoperidol ; Trifluperidol ; Trisedil ; Butyrophenone, 4'-fluoro-4-(4-hydroxy-4-(alpha,alpha,alpha-trifluoro-m-tolyl)piperidino)-
InChI:InChI=1/C22H23F4NO2/c23-19-8-6-16(7-9-19)20(28)5-2-12-27-13-10-21(29,11-14-27)17-3-1-4-18(15-17)22(24,25)26/h1,3-4,6-9,15,29H,2,5,10-14H2
CAS NO:749-13-3
Molecular Formula:C₂₂H₂₃F₄NO₂
Molecular Weight :409.4171
Molecular Structure :
Index of Refraction: 1.534
Surface Tension: 41.1 dyne/cm
Density: 1.26 g/cm³
Flash Point: 265.8 °C
Enthalpy of Vaporization: 82.95 kJ/mol
Boiling Point: 515.9 °C at 760 mmHg
Vapour Pressure: 1.8E-11 mmHg at 25°C

Uses

Trifluperidol (CAS NO.749-13-3) is a typical antipsychotic of the butyrophenone chemical class.It is used in the treatment of psychoses including mania and schizophrenia.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD50	subcutaneous	> 2500ug/kg (2.5mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
dog	LD50	subcutaneous	> 80mg/kg (80mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
monkey	LD50	subcutaneous	> 1250ug/kg (1.25mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
mouse	LD50	intravenous	26mg/kg (26mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
mouse	LD50	oral	110mg/kg (110mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT	Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1248, 1974.
mouse	LD50	subcutaneous	50mg/kg (50mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT	Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1248, 1974.
mouse	LDLo	intraperitoneal	150mg/kg (150mg/kg)		National Technical Information Service. Vol. AD691-490,
rat	LD50	intravenous	14mg/kg (14mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
rat	LD50	oral	140mg/kg (140mg/kg)		Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
rat	LD50	subcutaneous	70mg/kg (70mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE AUTONOMIC NERVOUS SYSTEM: CENTRAL SYMPATHOLYTIC BEHAVIORAL: ALTERATION OF CLASSICAL CONDITIONING	Medicinal Chemistry: A Series of Monographs. Vol. 4(2), Pg. 199, 1967.

Safety Profile

Poison by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of F⁻ and NO_x. See also FLUORIDES and TRIFLUPERIDOL HYDROCHLORIDE.

Specification

Trifluperidol (CAS NO.749-13-3) has general properties similar to those of haloperidol, but is considerably more potent by weight, and causes relatively more severe side effects, especially tardive dyskinesia and other extrapyramidal effects.