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Basic Information

Molecular Structure:
CAS No.:	77-86-1
Name:	Tris Base
Article Data:	35

Formula:	C₄H₁₁NO₃
Molecular Weight:	121.136
Synonyms:	Tris(hydroxymethyl)aminomrthane;Tris (hydroxymethyl) aminoethane;2-Amino-1,3-dihydroxy-2-(hydroxymethyl)propane;2-Amino-2-(hydroxymethyl)propane-1,3-diol;2-Amino-2-hydroxymethylpropan-1,3-diol;2-Amino-2-methylol-1,3-propanediol;Addex-Tham;Aminotri(hydroxymethyl)methane;Aminotrimethylolmethane;Aminotris(hydroxymethyl)methane;Methanamine,1,1,1-tris(hydroxymethyl)-;NSC 103026;NSC 6365;NSC 65434;Pehanorm;TAM(buffering agent);THAM;Talatrol;Tri Amino;Tri(hydroxymethyl)methylamine;Trigmo base;Triladyl;Trimethylolaminomethane;Tris (buffering agent);Tris Amino;Tris Amino Crystal;Tris base;Tris buffer;Tris(methylolamino)methane;[2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]amine;Tris Base; Tris(hydroxymethyl)-aminomethane;Trometamol;
EINECS:	201-064-4
Density:	1,353 g/cm3
Melting Point:	167-172 °C(lit.)
Boiling Point:	219-220 °C (10 mmHg)
Flash Point:	219-220°C/10mm
Solubility:	water: 4 M at 20 °C, clear, colorless
Appearance:	white crystalline powder
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	26-36-37/39
PSA:	86.71000
LogP:	-1.63890

Synthetic route

: {NiCl2(2-(2-pyridinyl)-4,4-bis(hydroxymethyl)-2-oxazoline)2}

A: {Ni(H2O)2(pyridine-2-carboxylic acid)2}*2H2O

B: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

Conditions

Conditions	Yield
In water reflux (50 h);; pptn.; filtration; washing (ethanol); drying (vac.); elem. anal.; evapn. of aq. filtrate; extraction (3 times/hot ethanol); cooling of filtrate yields 2-amino-2-hydroxymethyl-1,3-propanediol;;	A 85% B 75%

: 126-11-4
2-hydroxymethyl-2-nitro-propane-1,3-diol

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

Conditions

Conditions	Yield
With sulfuric acid; iron at 100℃;
With water; iron; iron(II) sulfate at 30℃;
With water; iron; iron(II) sulfate at 100℃;

: 19320-52-6
Protonated tris(hydroxymethyl)aminoamethane

: 114444-46-1
C14H13NO

A: 124225-44-1
1-methyl-4-(phenylacetyl)pyridinium cation

B: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

Conditions

Conditions	Yield
In water at 25℃; Equilibrium constant; Rate constant;

...Expand

: 19320-52-6
Protonated tris(hydroxymethyl)aminoamethane

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

Conditions

Conditions	Yield
In water; acetonitrile at 25℃; Thermodynamic data; ΔrGm0, var. of solvent, temp.;

: N,N'-bis(2,3-dihydroxypropyl)-5-{2-[(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)amino]-2-oxoethoxy}-1,3-benzenedicarboxamide

A: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

B: [3,5-Bis-(2,3-dihydroxy-propylcarbamoyl)-phenoxy]-acetic acid

Conditions

Conditions	Yield
With water at 95℃; Rate constant;

5-amino-5-hydroxymethyl-2-alkyl-1.3-dioxanene: 5-amino-5-hydroxymethyl-2-alkyl-1.3-dioxanene

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

Conditions

Conditions	Yield
With mineral acid

: Sodium; 2-{[(E)-2-hydroxy-1,1-bis-hydroxymethyl-ethylimino]-methyl}-benzenesulfonate

A: 1008-72-6
sodium 2-formylbenzenesulfonate

B: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

Conditions

Conditions	Yield
In water at 25℃; Equilibrium constant;

: C9H18NO10P(2-)*2Na(1+)

A: 108321-99-9, 150713-51-2
α,β-D-ribofuranose-5-phophate disodium salt

B: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

Conditions

Conditions	Yield
Equilibrium constant;

boc-Pro-Phe-His(Ts)-OH: boc-Pro-Phe-His(Ts)-OH

: diethylphosphoryl cyanide

A boc-Pro-Phe-His-LVA-Ile: boc-Pro-Phe-His-LVA-Ile

B: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride; triethylamine; trifluoroacetic acid In tetrahydrofuran; methanol; dichloromethane; ethyl acetate

...Expand

: tris(hydroxymethyl)aminomethane-silicofluoric acid (2/1)

A: 7664-39-3
hydrogen fluoride

B: 7783-61-1
silicon tetrafluoride

C: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

Conditions

Conditions	Yield
In neat (no solvent) thermogravimetric expt. (platinum crucible, heating rate of 10 K/min); heating to 200-268°C;

...Expand

Raw Materials

79-06-1

126-11-4

Downstream Products

96-26-4

59-67-6

Total:301 Page 1 of 8 1 2 3 4 5 6 …8 Next>>

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Specification

1. Introduction of Trometamol

The Tromethamine, with its CAS NO 77-86-1,is a kind of white Crystalline Powderthe. It has synonyms of 1,3-Propanediol, 2-amino-2-(hydroxymethyl)- ; 2-(Hydroxymethyl)-2-amino-1,3-propanediol ; 2-Amino-2-(hydroxymethyl)-1,3-propanediol ; 2-Amino-2-methylol-1,3-propanediol ; AI3-03948 ; Addex-tham ; Aminotrimethylolmethane ; Aminotris(hydroxymethyl)methane and Apiroserum Tham. Trometamol should be stored in shady and cool warehouse.

2. Properties of Trometamol

(1) Einecs: 201-064-4 (2) Index of Refraction: 1.544 (3) Molar Refractivity: 28.68 cm3
(4) Molar Volume: 90.8 cm3 (5) Melting Point: 167-172 °C(lit.) (6) Boiling point: 357 °C at 760 mmHg
(7) Flash Point: 169.7 °C (8) Density: 1.334 g/cm3 (9) Surface Tension: 73.2 dyne/cm
(10) Enthalpy of Vaporization: 69.73 kJ/mol (11) Vapour Pressure: 1.57E-06 mmHg at 25 °C
(12) XLogP3-AA: -2.9 (13) H-Bond Donor: 4 (14) H-Bond Acceptor: 4

3. Structure descriptors of Trometamol

Canonical SMILES: C(C(CO)(CO)N)O
InChI: InChI=1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2
InChIKey: LENZDBCJOHFCAS-UHFFFAOYSA-N

4. Safety information of Trometamol

Hazard Codes: Irritant
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S37/39:Wear suitable gloves and eye/face protection.

5. Toxicity data of Trometamol

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intravenous	1210mg/kg (1210mg/kg)		Acta Biologica et Medica Germanica. Vol. 17, Pg. 217, 1966.
rabbit	LDLo	oral	1gm/kg (1000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: COMA	Journal of Industrial Hygiene and Toxicology. Vol. 22, Pg. 315, 1940.
rat	LD50	intravenous	1800mg/kg (1800mg/kg)		Drugs in Japan Vol. -, Pg. 419, 1990.
rat	LD50	oral	5900mg/kg (5900mg/kg)		Bollettino Chimico Farmaceutico. Vol. 110, Pg. 653, 1971.

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