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| CAS No.: | 82-93-9 |
|---|---|
| Name: | CHLORCYCLIZINE |
| Article Data: | 7 |
| Molecular Structure: | |
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| Formula: | C18H21 Cl N2 |
| Molecular Weight: | 300.831 |
| Synonyms: | Piperazine,1-(p-chloro-a-phenylbenzyl)-4-methyl-(6CI,8CI); (?à)-Chlorcyclizine;1-(4-Chlorobenzhydryl)-4-methylpiperazine; 1-(p-Chloro-a-phenylbenzyl)-4-methylpiperazine;1-[(4-Chlorophenyl)phenylmethyl]-4-methylpiperazine; Alergicide; Chlorcycline;Chlorcyclizine; Chlorocycline; Compound 47-282; Di-Paralen;N-Methyl-N'-(4-chlorobenzhydryl)piperazine; NSC 25246; Perazyl; Trihistan |
| Density: | 1.0732 (rough estimate) |
| Melting Point: | 25°C |
| Boiling Point: | bp0.1-0.15 137-145° |
| Solubility: | 300.8mg/L(37.5 oC) |
| Safety: | Unspecified human reproductive effects. Experimental teratogenic and reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cl− and NOx. |
| PSA: | 6.48000 |
| LogP: | 3.55260 |
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- Total:14 Page 1 of 1 1
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Chemistry
IUPAC Name: 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine
Synonyms of Chlorocycline (CAS NO.82-93-9) : (1-[(4-Chlorophenyl)phenyl-methyl]-4-methylpiperazine) ; 1-(p-Chloro-a-phenylbenzyl)-4-methylpiperazine ; Perazil ; Piperazine, 1- (p-chloro-.alpha.-phenylbenzyl)-4-methyl-
CAS NO:82-93-9
Molecular Formula:C18H21ClN2
Molecular Weight :300.8257
Molecular Structure :
EINECS: 201-446-0
Index of Refraction: 1.59
Surface Tension: 43.9 dyne/cm
Density: 1.145 g/cm3
Flash Point: 191.9 °C
Enthalpy of Vaporization: 64.35 kJ/mol
Boiling Point: 393.6 °C at 760 mmHg
Vapour Pressure: 2.1E-06 mmHg at 25°C
Uses
Chlorocycline (CAS NO.82-93-9) is mainly used in allergic diseases and as antiemetic drug .
Production
Preparation Products: Meclozine
Raw materials :Etanol-->Hydrochloric acid-->Diethyl ether-->Sodium carbonate-->Sodium sulfate-->Sodium bicarbonate-->1-Methylpiperazine-->P-XYLENE-->4-Chlorobenzhydrol
Toxicity Data With Reference
| 1. | dni-rat-ipr 50 mg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 171 (1970),109. |
Safety Profile
Unspecified human reproductive effects. Experimental teratogenic and reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
Specification
Note of Chlorocycline (CAS NO.82-93-9):
1. There will be sleepiness and blurred vision, fatigue and other adverse reactions.
2. Drivers, machine operators, high-altitude operators used with caution.
3. A small number of patients have a rash, but lighter.