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CAS No.: | 90-22-2 |
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Name: | Valethamate bromide |
Molecular Structure: | |
Formula: | C19H32NO2.Br |
Molecular Weight: | 386.373 |
Synonyms: | Ammonium,diethyl(2-hydroxyethyl)methyl-, bromide, 3-methyl-2-phenylvalerate (8CI);Ethanaminium,N,N-diethyl-N-methyl-2-[(3-methyl-1-oxo-2-phenylpentyl)oxy]-, bromide (9CI);2-Diethylaminoethyl 2-phenyl-3-methylvalerate methyl bromide;2-Phenyl-3-methylvaleric acid b-(diethylamino)ethyl ester bromomethylate;Barespan;Elist;Epidosan;Letamate;Release V;S 78;Velamate; |
EINECS: | 201-977-8 |
Melting Point: | 120-127℃ |
Solubility: | almost transparency in Water |
Hazard Symbols: | Xi |
Risk Codes: | R36/37/38 |
PSA: | 26.30000 |
LogP: | 0.84990 |
The molecular structure of Valethamate bromide (90-22-2) as follow:
EINECS: 201-977-8
Molecular formula: C19H32BrNO2
Formula weight: 386.37
Synonyms: diethyl(methyl)(2-(3-methyl-2-phenylvaleryloxy)ethyl)ammonium bromide ; N,N-Diethyl-N-methyl-2-[(3-methyl-1-oxo-2-phenylpentyl)oxy]ethanaminium bromide ; N,N-Diethyl-N-methyl-2-(3-methyl-2-phenylvaleryloxy)ethylammonium bromide ; 2-Diethylaminoethyl 3-methyl-2-phenylvalerate methylbromide ; 2-Diethylaminoethyl 2-phenyl-3-methylvalerate methyl bromide ; 3-methyl-2-phenylvaleric acid 2-diethylaminoethylester methyl bromide
Appearance: White crystal powder
Valethamate bromide (90-22-2) is freely soluble in water and very soluble in alcohol, practically insoluble in ether.
Valethamate bromide (90-22-2) is generally used as an anticholinergic agent. It is applied to the spasmolysis and the inhibition of glandular secretion such as gastric ulcer, duodenal ulcer, gastritis, gastroxia and so on.
mouse | LD50 | intravenous | 4200ug/kg (4.2mg/kg) | Drugs in Japan Vol. 6, Pg. 352, 1982. | |
mouse | LD50 | oral | 330mg/kg (330mg/kg) | PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE | Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 599, 1955. |
mouse | LD50 | subcutaneous | 105mg/kg (105mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 245, 1974. | |
rabbit | LD50 | intravenous | 9500ug/kg (9.5mg/kg) | "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 123, 1969. | |
rat | LD50 | intravenous | 4200ug/kg (4.2mg/kg) | Drugs in Japan Vol. 6, Pg. 352, 1982. | |
rat | LD50 | oral | 1260mg/kg (1260mg/kg) | Drugs in Japan Vol. 6, Pg. 352, 1982. | |
rat | LD50 | subcutaneous | 575mg/kg (575mg/kg) | Drugs in Japan Vol. 6, Pg. 352, 1982. |
As aqueous solution, the storage of Valethamate bromide (90-22-2) is stable. As 0.6% ampuled solution, it is showed that Valethamate bromide (90-22-2) has no loss after one year at room temp.