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| CAS No.: | 91-84-9 |
|---|---|
| Name: | PYRILAMINE |
| Article Data: | 7 |
| Molecular Structure: | |
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| Formula: | C17H23 N3 O |
| Molecular Weight: | 285.389 |
| Synonyms: | 1,2-Ethanediamine,N-[(4-methoxyphenyl)methyl]-N',N'-dimethyl-N-2-pyridinyl- (9CI);Pyridine,2-[[2-(dimethylamino)ethyl](p-methoxybenzyl)amino]- (7CI,8CI);2-[(2-Dimethylaminoethyl)(p-methoxybenzyl)amino]pyridine;Afko-Hist;Anhistabs;Anhistol;Antalergan;Antallergan;Anthisan;Copsamine;Coradon;Dipane;Dorantamin;Harvamine;Histacap;Histasan;Isamin;Kriptin;Maranhist;Mepyramine;Mepyren;N-p-Methoxybenzyl-N',N'-dimethyl-N-a-pyridylethylenediamine;NSC13136;Neo-Bridal;Neoantergan;Nyscaps;Pyra;Pyranisamine;Pyrilamine;RP2786;Statomin;Wait's green mountain antihistamine; |
| EINECS: | 202-102-2 |
| Density: | 1.0141 (rough estimate) |
| Boiling Point: | bp5 201°; bp0.06 168-172° |
| Solubility: | 3.425g/L(37.5 oC) |
| Safety: | Human poison by an unspecified route. An experimental poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. An experimental teratogen. Human systemic effects by unspecified route: sleep effects, somnolence and muscle contraction or spasticity. Experimental reproductive effects. An eye irritant. When heated to decomposition it emits toxic fumes of NOx. Used as an antihistamine. |
| PSA: | 28.60000 |
| LogP: | 2.65840 |
- 958254-66-51H-Imidazo[4,5-b]pyridine-2-carboxaldehyde, 1-methyl-, hydrochloride
- 99170-93-1N-Methyl-2-oxazolamine
- 97730-31-9(S)-4'-(2-Methylbutyl)Biphenyl-4-Carbonitrile
- 926293-55-26-Bromo-2-methylpyridine-3-carboxaldehyde
- 95789-13-21,3,7-trimethylpurine-2,6-dione
- 956104-42-02-Bromo-5-nitro-3-(trifluoromethyl)pyridine
- 945683-37-41-butyl-2,3-dimethylimidazolium octanesulfate
- 946052-36-41-Butyl-3-methylpyridinium methanesulfonate
- 942196-38-51-Hexyl-3-methylpyridinium hexafluorophosphat
- 929897-32-51-hexyl-4-methylpridine hexafluorophosphate
- Total:25 Page 1 of 1 1
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Chemistry
Chemistry informtion about Pyrilamine (CAS NO.91-84-9) is:
IUPAC Name: N-[(4-methoxyphenyl)methyl]-N' , N'-dimethyl-N-pyridin-2-ylethane-1 , 2-diamine
Synonyms: 1,2-Ethanediamine , N-[(4-methoxyphenyl)methyl]-N' , N'-dimethyl-N-2-pyridinyl- ; 1,2-Ethanediamine , N-[(4-methoxyphenyl)methyl]-N' , N'-dimethyl-N-2-pyridyl- ; 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-pyridin ; 2-((2-(dimethylamino)ethyl)-(p-methoxybenzyl)amino)pyridine ; 2-((2-dimethylaminoethyl)(p-methoxybenzyl)amino)pyridine ; 2-((p-Methoxybenzyl)(2-(dimethylamino)ethyl)amino)pyridine ; 2-[[2-(Dimethylamino)ethyl](p-methoxybenzyl)amino]pyridine ; Afko-Hist
MF: C17H23N3O
MW: 285.38
EINECS: 202-102-2
Density: 1.088 g/cm3
Flash Point: 210.1 °C
Boiling Point: 423.8 °C at 760 mmHg
Vapour Pressure: 2.17E-07 mmHg at 25°C
Enthalpy of Vaporization: 67.82 kJ/mol
Following is the molecular structure of Pyrilamine (CAS NO.91-84-9) is:
Uses
Pyrilamine (CAS NO.91-84-9) is used as an antihistamine.
Toxicity Data With Reference
| 1. | eye-rbt 1% | OPHTAD Ophtalmologica. 143 (1962),154. | ||
| 2. | eye-rbt 100 mg MLD | FCTOD7 Food and Chemical Toxicology. 20 (1982),573. | ||
| 3. | ims-rat TDLo:50 mg/kg (5D preg):REP | PSEBAA Proceedings of the Society for Experimental Biology and Medicine. 100 (1959),555. | ||
| 4. | ipr-rat TDLo:350 mg/kg (10-16D preg):TER | JPHYA7 Journal of Physiology. 164 (1962),138. | ||
| 5. | unr-hmn TDLo:714 µg/kg:CNS | JOALAS Journal of Allergy, Including Allergy Abstracts. 19 (1948),313. | ||
| 6. | orl-mus LD50:220 mg/kg | THERAP Therapie. 26 (1971),1203. | ||
| 7. | ipr-mus LD50:107 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 25 (1975),1723. | ||
| 8. | scu-mus LD50:100 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 14 (8)(1964),940. | ||
| 9. | ivn-mus LD50:23 mg/kg | THERAP Therapie. 26 (1971),1203. |
Safety Profile
Human poison by an unspecified route. An experimental poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. An experimental teratogen. Human systemic effects by unspecified route: sleep effects, somnolence and muscle contraction or spasticity. Experimental reproductive effects. An eye irritant. When heated to decomposition it emits toxic fumes of NOx.
Specification
General description about Pyrilamine (CAS NO.91-84-9), it is a viscous brown liquid.
Air & Water Reactions: May be sensitive to light. Insoluble in water.
Reactivity Profile: It neutralizes acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate flammable gaseous hydrogen in combination with strong reducing agents, such as hydrides.
Health Hazard: Symptoms: Exposure to Pyrilamine may cause somnolence, central nervous system depression and gastrointestinal disturbances. It may also cause drowsiness, dryness of the mouth, headache, nausea, tachycardia, urinary retention, nervousness, disorientation, staggering gait, hallucinations, stupor, coma, hyperflexia, tremors, excitement, nystagmus, hyperthermia, convulsions, agranulocytosis and aplastic anemia.
Fire Hazard: Flash point data for it are not available; however, It is probably combustible.