1000-62-0 Usage
Description
1-Ethoxy-2-(trimethylsilyl)ethyne, also known as Ethoxy(trimethylsilyl)acetylene, is an organic compound with the molecular formula C6H12O2Si. It is characterized by the presence of an ethoxy group and a trimethylsilyl group attached to an ethyne backbone. 1-Ethoxy-2-(trimethylsilyl)ethyne exhibits unique reactivity and stability due to the presence of the trimethylsilyl group, which can be used to protect the ethyne moiety in various chemical reactions.
Uses
Used in Chemical Synthesis:
1-Ethoxy-2-(trimethylsilyl)ethyne is used as a mild agent for the conversion of carboxylic acids into carboxylic anhydrides. The trimethylsilyl group in this compound helps to facilitate the reaction by temporarily protecting the carboxylic acid, allowing for a more controlled and selective synthesis process.
Used in Dehydrative Condensation:
1-Ethoxy-2-(trimethylsilyl)ethyne is used as a dehydrative condensation agent for carboxylic acids, amines, and alcohols. The presence of the ethoxy group and the trimethylsilyl group enables the compound to act as a dehydrating agent, promoting the formation of desired products by removing water or other small molecules from the reaction mixture.
Used as a Trimethylsilylketene Precursor:
1-Ethoxy-2-(trimethylsilyl)ethyne can be used as a precursor for the synthesis of trimethylsilylketene, an important intermediate in the preparation of various organic compounds. The ethyne moiety in this compound can be converted into ketene through a series of reactions, providing a versatile building block for the synthesis of complex organic molecules.
Used in Cycloaddition Reactions:
1-Ethoxy-2-(trimethylsilyl)ethyne serves as a 2π component in cycloaddition reactions, a class of reactions that involve the formation of cyclic compounds from two or more unsaturated molecules. The ethyne backbone in this compound can participate in these reactions, leading to the formation of novel cyclic structures with potential applications in various fields.
Physical Properties:
1-Ethoxy-2-(trimethylsilyl)ethyne has a boiling point of 57 °C at a pressure of 34 mmHg and a density of 0.828 g/cm3. These properties make it suitable for use in various chemical processes, as it can be easily manipulated and controlled under a range of conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 1000-62-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,0 and 0 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1000-62:
(6*1)+(5*0)+(4*0)+(3*0)+(2*6)+(1*2)=20
20 % 10 = 0
So 1000-62-0 is a valid CAS Registry Number.
1000-62-0Relevant articles and documents
A MILD AND FACILE SYNTHESIS OF CARBOXYLIC ANHYDRIDES
Kita, Y.,Akai, S.,Yoshigi, M.,Nakajima, Y.,Yasuda, H.,Tamura, Y.
, p. 6027 - 6030 (1984)
Reaction of carboxylic acids with trimethylsilylethoxyacetylene in an inert solvent under mild conditions affords the corresponding carboxylic anhydrides in almost quantitative yields.
Linear, Mannitol-Based Poly(anhydride-esters) with High Ibuprofen Loading and Anti-Inflammatory Activity
Stebbins, Nicholas D.,Yu, Weiling,Uhrich, Kathryn E.
, p. 3632 - 3639 (2015)
Sugar alcohols, such as mannitol and xylitol, are biocompatible polyols that have been used to make highly cross-linked polyester elastomers and dendrimers for tissue engineering and drug delivery. However, research that utilizes the secondary hydroxyl gr
Ynol Ethers as Ketene Equivalents in Rhodium-Catalyzed Intermolecular [5 + 2] Cycloaddition Reactions
Wender, Paul A.,Ebner, Christian,Fennell, Brandon D.,Inagaki, Fuyuhiko,Schr?der, Birte
supporting information, p. 5810 - 5813 (2017/11/10)
The previously unexplored metal-catalyzed [5 + 2] cycloadditions of vinylcyclopropanes (VCPs) and electron-rich alkynes (ynol ethers) have been found to provide a highly efficient, direct route to dioxygenated seven-membered rings, a common feature of num
