1000684-25-2

Basic information

• Product Name: ethyl phenethyl 1,4-dihydro-2,6-dimethyl-4-(1-methyl-4,5-dichloroimidazole-2-yl)-3,5-pyridine dicarboxylate
• CAS NO: 1000684-25-2
• Molecular Weight: 478.375
• Mol File: 1000684-25-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl phenethyl 1,4-dihydro-2,6-dimethyl-4-(1-methyl-4,5-dichloroimidazole-2-yl)-3,5-pyridine dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl phenethyl 1,4-dihydro-2,6-dimethyl-4-(1-methyl-4,5-dichloroimidazole-2-yl)-3,5-pyridine dicarboxylate(1000684-25-2)
• EPA Substance Registry System: ethyl phenethyl 1,4-dihydro-2,6-dimethyl-4-(1-methyl-4,5-dichloroimidazole-2-yl)-3,5-pyridine dicarboxylate(1000684-25-2)

Safety Data

• Hazardous Substances Data: 1000684-25-2(Hazardous Substances Data)

Upstream product

• 24370-84-1 2-phenylethyl acetoacetate 

Relevant articles and documents

Synthesis, QSAR and calcium channel antagonist activity of new 1,4-dihydropyridine derivatives containing 1-methy 1-4,5-dichloroimidazolyl substituents

A group of dialkyl and diarylester analogues of nifedipine, in which the ortho-nitrophenyl group at position 4 was replaced by a 1-methyl-4,5- dichloroimidazolyl substituent, were synthesized and evaluated as calcium-channel antagonists using the high K+ concentration of guinea-pig ileum longitudinal smooth muscle. The structure of all compounds was confirmed by IR, 1H-NMR, and mass spectra. The calcium-channel antagonist activity of compounds 10a-f demonstrated that compound 10b was the most active and 10f the least active one. With unsymmetrical diesters 12a-k, the most active compound was the ethyl, phenethyl derivative. Structural parameters on the calcium-channel antagonist activity were evaluated by QSAR analysis and a linear correlation was found between the -log IC50 values of these compounds and their constitutional and topological properties.