100074-37-1

Basic information

• Product Name: phenylacetic acid
• Synonyms: phenylacetic acid
• CAS NO: 100074-37-1
• Molecular Weight: 301.137
• Mol File: 100074-37-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: phenylacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: phenylacetic acid(100074-37-1)
• EPA Substance Registry System: phenylacetic acid(100074-37-1)

Safety Data

• Hazardous Substances Data: 100074-37-1(Hazardous Substances Data)

Upstream product

• 105-36-2 ethyl bromoacetate 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 1421237-12-8 C₂₂H₂₁BrFNO₅ 
• 1514777-38-8 7-(4-(2-(3-(4-bromophenyl)furan-2(5H)-one-4-yloxy)ethyl)piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 1514777-43-5 7-(4-(2-(3-(4-bromophenyl)furan-2(5H)-one-4-yloxy)ethyl)piperazin-1-yl)-1-(4-fluorophenyl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 1514777-40-2 7-(4-(2-(3-(4-bromophenyl)furan-2(5H)-one-4-yloxy)ethyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 1339962-14-9 3-(4-bromophenyl)-4-((pyridin-2-yl)amino)furan-2(5H)-one 
• 1339962-13-8 3-(4-bromophenyl)-4-(phenylamino)furan-2(5H)-one 
• 1283094-31-4 3-(4-bromophenyl)-4-(3,5-dimethoxyphenylamino)furan-2(5H)-one 
• 1339962-23-0 3-(4-bromophenyl)-4-(3,5-difluorophenylamino)furan-2(5H)-one 
• 1339962-22-9 3-(4-bromophenyl)-4-(4-methylphenylamino)furan-2(5H)-one 
• 1283094-70-1 3-(4-bromophenyl)-4-(4-methoxyphenylamino)furan-2(5H)-one 
• 1339962-21-8 3-(4-bromophenyl)-4-(2-methoxyphenylamino)furan-2(5H)-one 
• 1283094-56-3 3-(4-bromophenyl)-4-(4-hydroxyphenylamino)furan-2(5H)-one 
• 1339962-20-7 3-(4-bromophenyl)-4-(3-hydroxyphenylamino)furan-2(5H)-one 
• 1283094-63-2 3-(4-bromophenyl)-4-(4-nitrophenylamino)furan-2(5H)-one 

Relevant articles and documents

Compound, as well as preparation method and application thereof

The application discloses a compound of which the structure is represented as the following formula, wherein R1 is selected from any one of F, Cl, Br, C1-C5 alkyl group, and a group having the structure as the formula (1), n = 0, 1, 2, 3, 4 or 5; the R2 is selected from any one of a group having the structure as the formula (1), a group having the structure as the formula (2), and a group having the structure as the formula (3). The compound has simple preparation method, can be used as a neuraminidase inhibitor, and has excellent antivirus activity.

Novel 3-arylfuran-2(5H)-one-fluoroquinolone hybrid: Design, synthesis and evaluation as antibacterial agent

3-Arylfuran-2(5H)-one, a novel antibacterial pharmacophore targeting tyrosyl-tRNA synthetase (TyrRS), was hybridized with the clinically used fluoroquinolones to give a series of novel multi-target antimicrobial agents. Thus, twenty seven 3-arylfuran-2(5H)-one-fluoroquinolone hybrids were synthesized and evaluated for their antimicrobial activities. Some of the hybrids exhibited merits from both parents, displaying a broad spectrum of activity against resistant strains including both Gram-negative and Gram-positive bacteria. The most potent compound (11) in antibacterial assay shows MIC50 of 0.11 μg/mL against Multiple drug resistant Escherichia coli, being about 51-fold more potent than ciprofloxacin. The enzyme assays reveal that 11 is a potent multi-target inhibitor with IC50 of 1.15 ± 0.07 μM against DNA gyrase and 0.12 ± 0.04 μM against TyrRS, respectively. Its excellent inhibitory activities against isolated enzymes and intact cells strongly suggest that 11 deserves to further research as a novel antibiotic.

Synthesis, structure, molecular docking, and structure-activity relationship analysis of enamines: 3-Aryl-4-alkylaminofuran-2(5H)-ones as potential antibacterials

Thirty-one 3-aryl-4-alkylaminofuran-2(5H)-ones were designed, prepared and tested for their antibacterial activity. Some of them showed significant antibacterial activity against Gram-positive organisms, especially against Staphylococcus aureus ATCC 25923, but all were inactive against Gram-negative organisms. Out of these compounds, 3-(4-bromophenyl)-4-(2-(4-nitrophenyl) hydrazinyl)furan-2(5H)-one (4a11) showed the most potent antibacterial activity against S. aureus ATCC 25923 with MIC50 of 0.42 μg/mL. The enzyme assay revealed that the possible antibacterial mechanism of the synthetic compounds might be due to their inhibitory activity against tyrosyl-tRNA synthetase. Molecular dockings of 4a11 into S. aureus tyrosyl-tRNA synthetase active site were also performed. This inhibitor snugly fitting the active site might well explain its excellent inhibitory activity. Meanwhile, this modeling disclosed that a more suitable optimization strategy might be to modify the benzene ring at 3-position of furanone with hydrophilic groups.