1000895-53-3

Basic information

• Product Name: 5-(3,5-diMethoxyphenethyl)-1H-pyrazol-3-aMine
• Synonyms: 5-(3,5-diMethoxyphenethyl)-1H-pyrazol-3-aMine;5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-amine;3-(3,5-diMethoxyphenethyl)-1H-pyrazol-5-aMine;AZD4547 intermediate;1H-Pyrazol-3-amine, 5-[2-(3,5-dimethoxyphenyl)ethyl]-
• CAS NO: 1000895-53-3
• Molecular Formula: C₁₃H₁₇N₃O₂
• Molecular Weight: 247.29298
• Mol File: 1000895-53-3.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• Density: 1.207
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 5-(3,5-diMethoxyphenethyl)-1H-pyrazol-3-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3,5-diMethoxyphenethyl)-1H-pyrazol-3-aMine(1000895-53-3)
• EPA Substance Registry System: 5-(3,5-diMethoxyphenethyl)-1H-pyrazol-3-aMine(1000895-53-3)

Safety Data

• Hazardous Substances Data: 1000895-53-3(Hazardous Substances Data)

Usage

General Description

5-(3,5-diMethoxyphenethyl)-1H-pyrazol-3-aMine, also known as 3C-E, is a psychedelic compound belonging to the phenethylamine and amphetamine chemical classes. It is a derivative of the phenethylamine hallucinogen mescaline and acts as a selective serotonin receptor agonist. 3C-E is known for its hallucinogenic effects, producing altered states of consciousness, visual and auditory hallucinations, and changes in perception. It is a potent psychoactive substance and is illegal in many countries due to its potential for abuse and harm. Research into the compound is limited, and its long-term effects on human health are not well understood.

Upstream product

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• 20767-04-8 (E)-3,5-dimethoxycinnamic acid 
• 75-05-8 acetonitrile 
• 302-01-2 hydrazine 

Downstream Products

• 1150263-21-0 2-chloro-N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]pyrimidin-4-amine 
• 1150262-52-4 N'-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-N-(pyridin-2-ylmethyl)pyrimidine-2,4-diamine 
• 1000893-66-2 N₄-(3-(3,5-dimethoxyphenylethyl)-1H-pyrazol-5-yl)-N₂-((3-methylisoxazol-5-yl)methyl)pyrimidine-2,4-diamine 

Relevant articles and documents

Pyrazole derivative for FGFR inhibitor and preparation method of pyrazole derivative

The invention provides a pyrazole derivative for an FGFR inhibitor and a preparation method of the pyrazole derivative. The invention specifically relates to an amide pyrazole compound serving as an FGFR irreversible inhibitor, and a preparation method and application thereof. The present invention provides a compound as shown in Formula I, or a pharmaceutically acceptable salt, or solvate, isotope substitute, prodrug, or metabolite thereof. The compound as shown in general formula I have FGFR inhibitory activity, and is capable of preventing or treating disorders associated with FGFR activityor expression, preferably such as cancer.

Method for preparing AZD4547, intermediate and preparation method of intermediate

The invention provides a method for preparing AZD-4547. The method comprises the following steps: (1) preparing a first intermediate 2-cyano-5-(3, 5-dimethoxyphenyl)-3-oxoethyl valerate; (2) preparinga second intermediate 5-[2-(3, 5-dimethoxyphenyl) ethyl]-1H-pyrazole-3-amine by taking the first intermediate as a raw material; and (3) in an alkali-containing organic solvent, carrying out a reaction on a third intermediate 4-((3S, 5R)-3, 5-dimethylpiperazinyl-1-yl) benzoyl chloride and the second intermediate to prepare the AZD-4547. The method has the advantages of accessible raw materials, simple technique, mild reaction conditions, convenient operation, high yield and low cost and can easily implement industrial production. The invention also provides an intermediate 2-cyano-5-(3, 5-dimethoxyphenyl)-3-oxoethyl valerate for preparing AZD-4547 and a preparation method thereof.

Synthetic process for 5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazole-3-amine

The invention belongs to the field of medicine chemical industries, and particularly relates to a new synthetic process for 5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazole-3-amine of an AZD4547 key intermediate. The synthetic process comprises the following steps: using 2-(3,5-dimethoxyphenyl) ethylpropionate as a starting raw material, in the presence of a basic catalyst and an organic solvent, reacting with acetonitrile, enabling an obtained product to perform cyclization with hydrazine hydrate in the presence of concentrated sulfuric acid, to obtain a target product of the 5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazole-3-amine. Compared with a current technology, the provided synthetic process for the 5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazole-3-amine is capable of greatly shortening thereaction time, enabling the yield of the product to be higher, wherein a process of purifying the intermediate does not exist between two steps of the reactions, shortening a reaction period, and reducing the wastewater discharge, and suitable for the industrialized mass production.