1001022-93-0Relevant articles and documents
Highly enantioselective thiourea-catalyzed nitro-mannich reactions
Yoon, Tehshik P.,Jacobsen, Eric N.
, p. 466 - 468 (2005)
(Chemical Equation Presented) Approaching "privileged" status? A new and highly effective enantioselective catalyst for the nitro-Mannich reaction was identified by modification of thioureabased Strecker catalysts (see scheme). Products are obtained in hi
Catalytic enantioselective aza-Henry reaction with broad substrate scope
Palomo, Claudio,Oiarbide, Mikel,Laso, Antonio,Lopez, Rosa
, p. 17622 - 17623 (2005)
In situ generated azomethines from readily available precursors react with nitromethane in the presence of 120 mol % of CsOH·H2O and 12 mol % of quinine- and cinchonidine-derived quaternary ammonium chlorides to provide the corresponding aza-He
Novel α-amino acid-derived phase-transfer catalyst application to a highly enantio- and diastereoselective nitro-Mannich reaction
Liu, Yuxin,Wei, Zhonglin,Leu, Yu,Cao, Jungang,Liang, Dapeng,Lin, Yingjie,Duan, Haifeng
supporting information, p. 9234 - 9242 (2017/11/14)
New quaternary ammonium types of bifunctional asymmetric phase-transfer catalysts bearing multiple hydrogen-bonding donors derived from α-amino acids were readily prepared and found to be highly efficient in the asymmetric nitro-Mannich reactions of amidosulfones. Very broad substrate generality was observed, and the products were achieved in high enantio-/diastereoselectivities (90->99.9% ee, 90:10 to 92:8 dr). Compared with previous reports, the enantioselectivity of aliphatic amidosulfones has been improved to a high level (91-93% ee).
Organocatalytic Enantioselective Transfer Hydrogenation of β-Amino Nitroolefins
Ferraro, Antonino,Bernardi, Luca,Fochi, Mariafrancesca
, p. 1561 - 1565 (2016/10/13)
The asymmetric organocatalytic transfer hydrogenation of β-acylamino and β-tert-butyloxycarbonylamino nitroolefins has been successfully realised in excellent enantioselectivities and yields (up to >99% ee, 97% yield) with a simple thiourea catalyst and a Hantzsch ester as hydrogen source, giving a direct access to enantiomerically pure β-amino nitroalkanes. (Figure presented.).
