1001058-65-6

Basic information

• Product Name: (S)-3-(4-bromophenyl)-4-nitrobutanal
• Synonyms: (S)-3-(4-bromophenyl)-4-nitrobutanal
• CAS NO: 1001058-65-6
• Molecular Weight: 272.098
• Mol File: 1001058-65-6.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: (S)-3-(4-bromophenyl)-4-nitrobutanal(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-(4-bromophenyl)-4-nitrobutanal(1001058-65-6)
• EPA Substance Registry System: (S)-3-(4-bromophenyl)-4-nitrobutanal(1001058-65-6)

Safety Data

• Hazardous Substances Data: 1001058-65-6(Hazardous Substances Data)

Upstream product

• 3156-37-4 (E)-1-bromo-4-(2-nitrovinyl)benzene 
• 80793-25-5 3-(4-bromophenyl)propanal 
• 75-52-5 nitromethane 
• 49678-04-8 4-bromocinnamaldeyde 
• 49678-04-8 trans-4-bromocinnamaldehyde 
• 3156-37-4 4-bromo-β-nitrostyrene 
• 75-07-0 acetaldehyde 
• 3156-37-4 C₈H₆BrNO₂ 
• 123-38-6 propionaldehyde 

Downstream Products

• 1140518-41-7 C₁₀H₁₂BrNO₃ 
• 1361412-60-3 (S)-methyl 3-(4-bromophenyl)-4-nitrobutanoate 

Relevant articles and documents

The Cyclohexa-2,5-dienyl Group as a Placeholder for Hydrogen: Organocatalytic Michael Addition of an Acetaldehyde Surrogate

An aldehyde with a cyclohexa-2,5-dienyl group in the α-position is introduced as a storable surrogate of highly reactive acetaldehyde. The cyclohexa-2,5-dienyl unit is compatible with an enantioselective Michael addition to nitroalkenes promoted by a Haya

Remote sulfonamido group enhances reactivity and selectivity for asymmetric michael addition of nitroalkanes to α,β-unsaturated aldehydes

The pyrrolidine-camphorsulfonamide-based catalyst 1 a catalyzes the enantioselective conjugate addition of nitroalkanes to α,β- unsaturated aldehydes in the presence of five equivalents of water in iPrOH to give the corresponding chiral Michael adducts in good yields and high enantioselectivities (up to 99 % ee) with a catalyst loading as low as 1 mol%.

Asymmetric synthesis of γ-nitroesters by an organocatalytic one-pot strategy

An enantioselective synthesis of γ-nitroesters by a one-pot asymmetric Michael addition/oxidative esterification of α,β- unsaturated aldehydes is presented. The procedure is based on merging the enantioselective organocatalytic nitroalkane addition with an N-bromosuccinimide-based oxidation. The γ-nitroesters are obtained in good yields and enantioselectivities, and the method provides an attractive entry to optically active γ-aminoesters, 2-piperidones, and 2-pyrrolidones.