100132-04-5Relevant articles and documents
NOVEL OXABISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS
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Page/Page column 68-69, (2008/06/13)
There is provided compounds of formula I, wherein R1, R2, R4, R41 to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.
PARTICIPATION OF A NEIGHBORING AMIDE GROUP IN THE HYDROLYTIC C-OAr CLEAVAGE OF N-(ω-PHENOXYALKYL)AMIDES. PART I. N,N-BIS(2-PHENOXYETHYL)PROPIONAMIDE
Dobrzeniecka, Regina
, p. 1135 - 1140 (2007/10/02)
The acid catalyzed hydrolysis of N,N-bis(2-phenoxyethyl)propionamide has been made at 74.8, 84.5 and 94,5 deg C, yielding both bis(2-phenoxyethyl)amine (A) and N,N-(2-phenoxy-2'-hydroxy)diethylamine (B) and phenol.The assistance from the amido group in a displacement of phenol was observed.Kinetic studies have been used to analyze the pathway.The results show that both the amines are formed in two parallel reactions of pseudo-first-order rate constants with kB/kA = 1.20 - 1.77 at 94.5 deg C depending on the concentration of hydrochloric acid.