10022-66-9 Usage
Description
Potassium osmate(VI) dihydrate, with the chemical formula H4K2O6Os, is an inorganic compound featuring osmium in the +6 oxidation state. This diamagnetic purple salt is soluble in water and slowly decomposes in aqueous solutions, while remaining insoluble in ethereal and alcoholic solvents. It presents as a violet crystalline powder.
Uses
1. Used in Water Quality Analysis:
Potassium osmate(VI) dihydrate is used as a reagent for the determination of nitrogenous matter in water, aiding in the assessment of water quality and contamination levels.
2. Used in Organic Synthesis Olefin Oxidation:
In the chemical industry, potassium osmate(VI) dihydrate serves as a catalyst for the oxidative cleavage of olefins to produce ketones and carboxylic acids. This application is crucial for the synthesis of various organic compounds and materials.
3. Used in Organic Synthesis Intramolecular Amidohydroxylation:
Potassium osmate(VI) dihydrate is utilized as a catalyst in the intramolecular amidohydroxylation of carbamoyloxytethered olefins, leading to the formation of hydroxy oxazolidinones. This reaction is significant for the synthesis of complex molecular structures.
4. Used in Pharmaceutical Synthesis Amphidinolide B:
In the pharmaceutical industry, potassium osmate(VI) dihydrate is employed as a reagent in the synthesis of amphidinolide B, a compound with potent antitumor activity against human solid and blood tumor cells. Its use in this process contributes to the development of novel cancer treatments.
Preparation
Edmond Fremy first prepared potassium osmate (VI) dehydrate in 1844 by reducing perosmates using alcohol.
2OsO4 + C2H5OH + 3 KOH → CH3CO2K + 2 K2[OsO2(OH)4]
Applications and Reactions
Potassium osmate (VI) dehydrate is used as a catalyst in the dihydroxylation of cyclic internal alkenes such as lactams, 1,2 dioxines dihydrothiophenes and hexahydropyrans. The resulting diols from such reactions have been used in the preparation of various carbohydrate and similar molecular scaffolds. Potassium osmate (VI) dehydrate iss also used in the development of an asymmetric dihydroxylation methodology targeting heteroaromatic acrylates.
Hazard
Toxic by ingestion and inhalation.
Check Digit Verification of cas no
The CAS Registry Mumber 10022-66-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,0,2 and 2 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 10022-66:
(7*1)+(6*0)+(5*0)+(4*2)+(3*2)+(2*6)+(1*6)=39
39 % 10 = 9
So 10022-66-9 is a valid CAS Registry Number.
InChI:InChI=1/2K.4O.Os/q2*+1;;;;;-2/r2K.O4Os/c;;1-5(2,3)4/q2*+1;-2
