1002304-34-8 Usage
Description
AMG-208, also known as 7-methoxyquinoline, is a member of the quinolines class that features a (6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy group substitution at position 4. It is a pharmaceutical compound with significant antitumor activity, particularly in prostate cancer.
Uses
Used in Pharmaceutical Industry:
AMG-208 is used as an antitumor agent for its ability to target and combat prostate cancer. It has demonstrated potential in inhibiting tumor growth and progression, making it a promising candidate for cancer treatment.
Used in Cancer Research:
In the field of cancer research, AMG-208 is utilized as a subject of study to better understand its mechanisms of action and potential applications in treating various types of cancer. Its unique chemical structure and antitumor properties make it an interesting compound for further investigation and development.
Check Digit Verification of cas no
The CAS Registry Mumber 1002304-34-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,2,3,0 and 4 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1002304-34:
(9*1)+(8*0)+(7*0)+(6*2)+(5*3)+(4*0)+(3*4)+(2*3)+(1*4)=58
58 % 10 = 8
So 1002304-34-8 is a valid CAS Registry Number.
InChI:InChI=1S/C22H17N5O2/c1-28-16-7-8-17-19(13-16)23-12-11-20(17)29-14-22-25-24-21-10-9-18(26-27(21)22)15-5-3-2-4-6-15/h2-13H,14H2,1H3
1002304-34-8Relevant articles and documents
Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase
Albrecht, Brian K.,Harmange, Jean-Christophe,Bauer, David,Berry, Loren,Bode, Christiane,Boezio, Alessandro A.,Chen, April,Choquette, Deborah,Dussault, Isabelle,Fridrich, Cary,Hirai, Satoko,Hoffman, Doug,Larrow, Jay F.,Kaplan-Lefko, Paula,Lin, Jasmine,Lohman, Julia,Long, Alexander M.,Moriguchi, Jodi,O'Connor, Anne,Potashman, Michele H.,Reese, Monica,Rex, Karen,Siegmund, Aaron,Shah, Kavita,Shimanovich, Roman,Springer, Stephanie K.,Teffera, Yohannes,Yang, Yajing,Zhang, Yihong,Bellon, Steven F.
supporting information; experimental part, p. 2879 - 2882 (2009/05/30)
Tumorigenesis is a multistep process in which oncogenes play a key role in tumor formation, growth, and maintenance. MET was discovered as an oncogene that is activated by its ligand, hepatocyte growth factor. Deregulated signaling in the c-Met pathway ha
