10025-99-7Relevant articles and documents
Synthesis and some physicochemical properties of the aqua complexes of covalent conjugates of platinum(II) with octacarboxy-substituted cobalt phthalocyanine
Dolotova,Kaliya
, p. 111 - 115 (2007)
Aqua complexes of the covalent conjugates of octacarboxy-substituted cobalt phthalocyanine with platinum, which are of interest as components of a catalytic system for cancer therapy, were synthesized. For the tetraplatinated product, elemental analysis data and the data from electronic absorption, IR, and mass spectra are given. Nauka/Interperiodica 2007.
Crystal structure, DNA-binding ability and cytotoxic activity of platinum(II) 2,2′-dipyridylamine complexes
Tu, Chao,Wu, Xuefeng,Liu, Qin,Wang, Xiaoyong,Xu, Qiang,Guo, Zijian
, p. 95 - 102 (2004)
Two platinum(II) complexes, [Pt(dpa)Cl2] (1) and [Pt(dpa)CBDCA] (2), where DPA=2,2′-dipyridylamine and CBDCA=1,1-cyclobutanedicarboxylate, were synthesized and characterized by elemental analysis, IR spectroscopy, ES-MS and X-ray diffraction. Intermolecular hydrogen bonds were observed in both complexes (N-H?Cl for complex 1 and N-H?O for complex 2), which may play a role in formation of hydrogen bonding in metal-DNA adducts. Complex 2 adopts a boat conformation so that the cyclobutane ring and bipyridyl groups are on the same side of the platinum square. The interactions of complexes 1 and 2 with DNA were studied by UV and Fluorescence Spectroscopy, which indicated that both complexes could interact with DNA through groove binding or intercalation. The in vitro cytotoxic activity against melanoma B16-BL6 cells and human Jurkat T-cells was also reported.
Coordination chemistry of platinum and palladium in the solid-state: Synthesis of imidazole and pyrazole complexes
Adams, Christopher J.,Haddow, Mairi F.,Hughes, Robert J.I.,Kurawa, Mukhtar A.,Orpen, A. Guy
, p. 3714 - 3724 (2010/06/17)
Solid-state reactions of palladium(ii) and platinum(ii) chloride complexes with imidazole (Him) and pyrazole (Hpz) or their hydrochloride salts are shown to produce metal complex salts and coordination compounds. Thus, K 2[MCl4] or MCl2 can be ground with imidazolium chloride ([H2im]Cl) to produce the salts [H2im] 2[MCl4] (M = Pd, 1; Pt, 5), which can then be dehydrochlorinated in the solid state to produce the coordination compounds trans-[PdCl2(Him)2] 3 or cis-[PtCl2(Him) 2] 6. The complex cis-[PdCl2(Him)2] 2 is produced when Pd(OAc)2 is ground with [H2im]Cl. Reaction of platinum chloride reagents with imidazole (Him) also produces cis-[PtCl 2(Him)2] 6, but reaction of imidazole with analogous palladium chloride reagents first produces [Pd(Him)4]Cl24 which then slowly converts to trans-[PdCl2(Him)2] 3. Grinding pyrazolium chloride with K2[MCl4] produces [H2pz]2[MCl4] (M = Pd, 7; Pt, 10), which may also be dehydrochlorinated in the solid state to produce the coordination compounds trans-[PdCl2(Hpz)2] 8 or cis-[PtCl 2(Hpz)2] 11. Grinding K2[PdCl4] or PdCl2 with pyrazole gives [Pd(Hpz)4]Cl29, which is then slowly converted into trans-[PdCl2(Hpz)2] 8. Grinding PtCl2 with Hpz generates [Pt(Hpz)4]Cl 212, but using K2PtCl4 as the metal source does not generate the same product. The single-crystal structures of 8, a new polymorph of 11 and [H2pz]2[PtCl6] ·2H2O (isolated as a decomposition product) are reported for the first time, and the structures of 5 and 10 have been solved ab ibitio from XRPD data.