1003-98-1

Basic information

• Product Name: 2-Bromo-4-fluoroaniline
• Synonyms: 4-FLUORO-2-BROMOANILINE;2-BROMO-4-FLUORO-PHENYLAMINE;2-BROMO-4-FLUOROANILINE;Bromofluoroaniline1;2-Bromo-4-fluoroaniline 99%;2-Bromo-4-fluoroaniline99%;2-BROMO-4-FLUOROANILINE 98+%;Benzenamine, 2-bromo-4-fluoro-
• CAS NO: 1003-98-1
• Molecular Formula: C₆H₅BrFN
• Molecular Weight: 190.01
• EINECS: -0
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds;Fluorobenzene;Miscellaneous;Anilines, Amides & Amines;Bromine Compounds;Fluorine Compounds;Amines;C2 to C6;Nitrogen Compounds;amine| alkyl Fluorine| alkyl bromide;Pyridines
• Mol File: 1003-98-1.mol
• Article Data: 17

Chemical Properties

• Melting Point: 41
• Boiling Point: 221 °C(lit.)
• Flash Point: 220 °F
• Appearance: Clear yellow-brown/Liquid
• Density: 1.67 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0743mmHg at 25°C
• Refractive Index: n20/D 1.583(lit.)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.60±0.10(Predicted)
• BRN: 2802562
• CAS DataBase Reference: 2-Bromo-4-fluoroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-4-fluoroaniline(1003-98-1)
• EPA Substance Registry System: 2-Bromo-4-fluoroaniline(1003-98-1)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36/37/38
• Safety Statements: 26-37/39
• RIDADR: UN2810
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 1003-98-1(Hazardous Substances Data)

Usage

Description

2-Bromo-4-fluoroaniline is an aryl fluorinated building block, which is a clear yellow-brown liquid. It is a chemical compound that has a bromine atom at the 2nd position and a fluorine atom at the 4th position on the aniline molecule.

Uses

Used in Pharmaceutical Industry:
2-Bromo-4-fluoroaniline is used as an intermediate for the synthesis of various pharmaceutical compounds. Its unique structure with both bromine and fluorine atoms makes it a valuable building block for creating new drugs with specific properties and functions.
Used in Chemical Synthesis:
2-Bromo-4-fluoroaniline is used as a starting material for the production of various organic compounds. Its aryl fluorinated nature allows for further chemical reactions and modifications, leading to the development of new molecules with potential applications in different industries.
Used in Research and Development:
2-Bromo-4-fluoroaniline is used as a research compound in the field of organic chemistry and medicinal chemistry. It serves as a model compound to study the effects of bromine and fluorine substitution on the properties and reactivity of aniline derivatives, which can provide insights into the design of new molecules with desired characteristics.

InChI:InChI=1/C6H5BrFN/c7-5-2-1-4(8)3-6(5)9/h1-3H,9H2

Upstream product

• 371-40-4 4-fluoroaniline 
• 1009-22-9 N-(2-bromo-4-fluorophenyl)acetamide 
• 90493-85-9 N-(2-bromophenyl)-N-hydroxyacetamide 
• 351-83-7 4'-fluoroacetanilide 

Downstream Products

• 166818-87-7 (2-amino-5-fluorophenyl)phosphonate de diethyle 
• 371-40-4 4-fluoroaniline 
• 1027046-05-4 3-benzo[1,3]dioxol-5-yl-N-(2-bromo-4-fluoro-phenyl)-acrylamide 
• 393509-21-2 ethyl (7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate 
• 571170-84-8 [2-(2-bromo-4-fluoro-phenylimino)-cyclopentyl]-acetic acid ethyl ester 
• 443-69-6 5-fluoro-1H-indole-2,3-dione 
• 877169-04-5 4'-chloro-5,3'-difluoro-biphenyl-2-yl-amine 
• 163688-20-8 2-ethyl-5-fluoro-1H-indole 
• 399-72-4 5-fluoro-2-methyl-1H-indole 
• 59541-83-2 5-fluoro-2-phenyl-1H-indole 
• 1048344-65-5 2-bromo-N-phenyl-4-fluorobenzeneamine 
• 1016170-26-5 N-benzyl-2-bromo-4-fluorobenzeneamine 
• 1717-22-2 2-amino-5-fluorobiphenyl 
• 1123762-09-3 N-(1'-methoxy)cyclopropyl-2-bromo-4-fluoroaniline 

Relevant articles and documents

Synthesis of 6-carboxylated phenanthridines by oxidative alkoxycarbonylation-cyclization of 2-isocyanobiphenyls with carbazates

An iron-catalyzed synthesis of 6-carboxylated phenanthridines starting with readily prepared isocyanides and carbazates was developed. Reactions occurred via addition of alkoxycarbonyl radicals to the isocyanide group and subsequent intramolecular cyclization.

Mild and regioselective oxidative bromination of anilines using potassium bromide and sodium perborate

The selective monobromination of various deactivated anilines using potassium bromide and sodium perborate as oxidant has been achieved. The use of ammonium molybdate as catalyst accelerates the rate of reaction but is not essential to obtain good yields and high selectivities. (C) 2000 Elsevier Science Ltd.

Selective Thiocyanation and Aromatic Amination to Achieve Organized Annulation of Enaminone with Thiocyanate

A tandem insertion of thiocyanate to enamine was performed for the regioselective synthesis of multisubstituted benzoimidazo[2,1-b]thiazoles. This method was shown to be effective in addressing the issue of isomerization encountered in common strategies. With a change made to the leading group on the aniline fragment of enamine, the reaction achieved different transformations, thus enabling multisubstituted benzo[4,5]imidazo[2,1-b]thiazoles and thiazoles in satisfactory yields.

Nitromethane as a reagent for the synthesis of 3-nitroindoles from 2-haloarylamine derivatives

A new approach to the synthesis of 3-nitroindoles using palladium-catalyzed arylation of nitromethane with N-(2-bromoaryl)imidates was developed. A convenient and rapid method for cyclization of ethyl N-(2-nitromethylaryl)acetimidates to 2-methyl-3-nitro-1H-indoles was proposed.